Persistent Pulmonary Hypertension of the Newborn - Mattel ...
Persistent Pulmonary Hypertension of the Newborn - Mattel ...
Persistent Pulmonary Hypertension of the Newborn - Mattel ...
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Animal Toxicity Studies:• Ten mechanically ventilated anes<strong>the</strong>tized piglets• High dose IPGE 1 (1200 ng/kg/min) or nebulized NS for 24 hNormal bronchus andadjacent alveoli in apiglet who receivedIPGE 1for 24 hFew neutrophils andred blood cells in <strong>the</strong>bronchus (arrow) andminimal alveolaredema (arrowhead)• No evidence <strong>of</strong> adverse cardio-respiratory respiratory effects,bronchial irritation or hypernatremia related to IPGE 1• No evidence <strong>of</strong> severe toxic injury:• Hyaline membranes• Diffuse/severe neutrophilic infiltration• Diffuse/severe ulceration• Distinct histologic findings in IPGE 1 animals:• Focal ulceration• Focal flattening <strong>of</strong> <strong>the</strong> bronchial epi<strong>the</strong>lium• Focal loss <strong>of</strong> cilia <strong>of</strong> moderate to severe degreeSood et al, Pulm Pharm Ther, 2008
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