Persistent Pulmonary Hypertension of the Newborn - Mattel ...
Persistent Pulmonary Hypertension of the Newborn - Mattel ...
Persistent Pulmonary Hypertension of the Newborn - Mattel ...
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Effect on Ductus Arteriosus• Echocardiograms obtained before andafter study in 5 animals• High dose IPGE 1for 24 hrs did notopen a functionally closed DA• In one animal with small DA,administration <strong>of</strong> IPGE 1did not change<strong>the</strong> size <strong>of</strong> <strong>the</strong> DATable 3: Morphometry <strong>of</strong> <strong>the</strong> DA at AutopsyControl(n=6)IPGE 1(n=9)Length 0.47 (0.05) 0.49 (0.06)Circumference (Aortic) 0.33 (0.08) 0.34 (0.09)Circumference (<strong>Pulmonary</strong>) 0.33 (0.08) 0.33 (0.11)Values represent mean (SD) in mm. Group differences not significantControlIPGE 1Gittenberger-de Groot, 1980Sood et al, POLM, 2009
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