Persistent Pulmonary Hypertension of the Newborn - Mattel ...
Persistent Pulmonary Hypertension of the Newborn - Mattel ...
Persistent Pulmonary Hypertension of the Newborn - Mattel ...
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Challenges: RCTs in PPHN• Alternatives:• Study designs:• Fully sequential• Adaptive• Pragmatic trials• Opportunistic• Endpoints• Duration <strong>of</strong> intensive care, hospitalization, cost-effectiveness• Resource poor settings - Networks/Registry