18 de 0ctubre de 2010 www.elsuapdetodos.com1234 J.P. Nolan et al. / <strong>Resuscitation</strong> 81 (2010) 1219–1276Intravascular accessEstablish intravenous access if this has not already beenachieved. Peripheral venous cannulation is quicker, easier to per<strong>for</strong>mand safer than central venous cannulation. Drugs injectedperipherally must be followed by a flush of at least 20 ml of fluid. Ifintravenous access is difficult or impossible, consider the IO route.Intraosseous injection of drugs achieves adequate plasma concentrationsin a time comparable with injection through a centralvenous catheter. 242 The recent availability of mechanical IO deviceshas increased the ease of per<strong>for</strong>ming this technique. 243Unpredictable plasma concentrations are achieved when drugsare given via a tracheal tube, and the optimal tracheal dose of mostdrugs is unknown, thus, the tracheal route <strong>for</strong> drug delivery is nolonger recommended.DrugsAdrenaline. Despite the widespread use of adrenaline duringresuscitation, and several studies involving vasopressin, there is noplacebo-controlled study that shows that the routine use of anyvasopressor at any stage during human cardiac arrest increasesneurologically intact survival to hospital discharge. Despite thelack of human data, the use of adrenaline is still recommended,based largely on animal data and increased short-term survival inhumans. 227,228 The optimal dose of adrenaline is not known, andthere are no data supporting the use of repeated doses. There arefew data on the pharmacokinetics of adrenaline during <strong>CPR</strong>. Theoptimal duration of <strong>CPR</strong> and number of shocks that should be givenbe<strong>for</strong>e giving drugs is unknown. There is currently insufficient evidenceto support or refute the use of any other vasopressor asan alternative to, or in combination with, adrenaline in any cardiacarrest rhythm to improve survival or neurological outcome.On the basis of expert consensus, <strong>for</strong> VF/VT give adrenaline afterthe third shock once chest compressions have resumed, and thenrepeat every 3–5 min during cardiac arrest (alternate cycles). Donot interrupt <strong>CPR</strong> to give drugs.Anti-arrhythmic drugs. There is no evidence that giving anyanti-arrhythmic drug routinely during human cardiac arrestincreases survival to hospital discharge. In comparison withplacebo 244 and lidocaine, 245 the use of amiodarone in shockrefractoryVF improves the short-term outcome of survival tohospital admission. On the basis of expert consensus, if VF/VT persistsafter three shocks, give 300 mg amiodarone by bolus injection.A further dose of 150 mg may be given <strong>for</strong> recurrent or refractoryVF/VT, followed by an infusion of 900 mg over 24 h. Lidocaine,1mgkg −1 , may be used as an alternative if amiodarone is not available,but do not give lidocaine if amiodarone has been given already.Magnesium. The routine use of magnesium in cardiac arrestdoes not increase survival. 246–250 and is not recommended in cardiacarrest unless torsades de pointes is suspected (see peri-arrestarrhythmias).Bicarbonate. Routine administration of sodium bicarbonateduring cardiac arrest and <strong>CPR</strong> or after ROSC is not recommended.Give sodium bicarbonate (50 mmol) if cardiac arrest is associatedwith hyperkalaemia or tricyclic antidepressant overdose; repeatthe dose according to the clinical condition and the result of serialblood gas analysis.Non-shockable rhythms (PEA and asystole)and can be treated if those conditions are identified and corrected.Survival following cardiac arrest with asystole or PEA is unlikelyunless a reversible cause can be found and treated effectively.If the initial monitored rhythm is PEA or asystole, start <strong>CPR</strong> 30:2and give adrenaline 1 mg as soon as venous access is achieved. Ifasystole is displayed, check without stopping <strong>CPR</strong>, that the leads areattached correctly. Once an advanced airway has been sited, continuechest compressions without pausing during ventilation. After2 min of <strong>CPR</strong>, recheck the rhythm. If asystole is present, resume <strong>CPR</strong>immediately. If an organised rhythm is present, attempt to palpatea pulse. If no pulse is present (or if there is any doubt about the presenceof a pulse), continue <strong>CPR</strong>. Give adrenaline 1 mg (IV/IO) everyalternate <strong>CPR</strong> cycle (i.e., about every 3–5 min) once vascular accessis obtained. If a pulse is present, begin post-resuscitation care. Ifsigns of life return during <strong>CPR</strong>, check the rhythm and attempt topalpate a pulse.During the treatment of asystole or PEA, following a 2-min cycleof <strong>CPR</strong>, if the rhythm has changed to VF, follow the algorithm <strong>for</strong>shockable rhythms. Otherwise, continue <strong>CPR</strong> and give adrenalineevery 3–5 min following the failure to detect a palpable pulse withthe pulse check. If VF is identified on the monitor midway through a2-min cycle of <strong>CPR</strong>, complete the cycle of <strong>CPR</strong> be<strong>for</strong>e <strong>for</strong>mal rhythmand shock delivery if appropriate – this strategy will minimiseinterruptions in chest compressions.AtropineAsystole during cardiac arrest is usually caused by primarymyocardial pathology rather than excessive vagal tone and thereis no evidence that routine use of atropine is beneficial in thetreatment of asystole or PEA. Several recent studies have failedto demonstrate any benefit from atropine in out-of-hospital or inhospitalcardiac arrests 226,251–256 ; and its routine use <strong>for</strong> asystoleor PEA is no longer recommended.Potentially reversible causesPotential causes or aggravating factors <strong>for</strong> which specific treatmentexists must be considered during any cardiac arrest. For easeof memory, these are divided into two groups of four based upontheir initial letter: either H or T. More details on many of theseconditions are covered in Section 8. 10Fibrinolysis during <strong>CPR</strong>Fibrinolytic therapy should not be used routinely in cardiacarrest. 257 Consider fibrinolytic therapy when cardiac arrest iscaused by proven or suspected acute pulmonary embolus. Followingfibrinolysis during <strong>CPR</strong> <strong>for</strong> acute pulmonary embolism, survivaland good neurological outcome have been reported in cases requiringin excess of 60 min of <strong>CPR</strong>. If a fibrinolytic drug is given in thesecircumstances, consider per<strong>for</strong>ming <strong>CPR</strong> <strong>for</strong> at least 60–90 minbe<strong>for</strong>e termination of resuscitation attempts. 258,259 Ongoing <strong>CPR</strong>is not a contraindication to fibrinolysis.www.elsuapdetodos.comIntravenous fluidsHypovolaemia is a potentially reversible cause of cardiac arrest.Infuse fluids rapidly if hypovolaemia is suspected. In the initialstages of resuscitation there are no clear advantages to using colloid,so use 0.9% sodium chloride or Hartmann’s solution. Whetherfluids should be infused routinely during primary cardiac arrest iscontroversial. Ensure normovolaemia, but in the absence of hypovolaemia,infusion of an excessive volume of fluid is likely to beharmful. 260Pulseless electrical activity (PEA) is defined as cardiac arrest inthe presence of electrical activity that would normally be associatedwith a palpable pulse. PEA is often caused by reversible conditions,Use of ultrasound imaging during advanced life supportSeveral studies have examined the use of ultrasound duringcardiac arrest to detect potentially reversible causes. Although no
18 de 0ctubre de 2010 www.elsuapdetodos.comJ.P. Nolan et al. / <strong>Resuscitation</strong> 81 (2010) 1219–1276 1235studies have shown that use of this imaging modality improves outcome,there is no doubt that echocardiography has the potentialto detect reversible causes of cardiac arrest (e.g., cardiac tamponade,pulmonary embolism, aortic dissection, hypovolaemia,pneumothorax). 261–268 When available <strong>for</strong> use by trained clinicians,ultrasound may be of use in assisting with diagnosis andtreatment of potentially reversible causes of cardiac arrest. Theintegration of ultrasound into advanced life support requiresconsiderable training if interruptions to chest compressionsare to be minimised. A sub-xiphoid probe position has beenrecommended. 261,267,269 Placement of the probe just be<strong>for</strong>e chestcompressions are paused <strong>for</strong> a planned rhythm assessment enablesa well-trained operator to obtain views within 10 s. Absence ofcardiac motion on sonography during resuscitation of patients incardiac arrest is highly predictive of death 270–272 although sensitivityand specificity has not been reported.management should be able to undertake laryngoscopy withoutstopping chest compressions; a brief pause in chest compressionswill be required only as the tube is passed through the vocal cords.No intubation attempt should interrupt chest compressions <strong>for</strong>more than 10 s. After intubation, tube placement must be confirmedand the tube secured adequately.Several alternative airway devices have been considered <strong>for</strong> airwaymanagement during <strong>CPR</strong>. There are published studies on theuse during <strong>CPR</strong> of the Combitube, the classic laryngeal mask airway(cLMA), the Laryngeal Tube (LT) and the I-gel, but none of thesestudies have been powered adequately to enable survival to bestudied as a primary endpoint; instead, most researchers have studiedinsertion and ventilation success rates. The supraglottic airwaydevices (SADs) are easier to insert than a tracheal tube and, unliketracheal intubation, can generally be inserted without interruptingchest compressions. 283Airway management and ventilationPatients requiring resuscitation often have an obstructed airway,usually secondary to loss of consciousness, but occasionallyit may be the primary cause of cardiorespiratory arrest. Promptassessment, with control of the airway and ventilation of the lungs,is essential. There are three manoeuvres that may improve thepatency of an airway obstructed by the tongue or other upper airwaystructures: head tilt, chin lift, and jaw thrust.Despite a total lack of published data on the use of nasopharyngealand oropharyngeal airways during <strong>CPR</strong>, they are often helpful,and sometimes essential, to maintain an open airway, particularlywhen resuscitation is prolonged.During <strong>CPR</strong>, give oxygen whenever it is available. There are nodata to indicate the optimal arterial blood oxygen saturation (SaO 2 )during <strong>CPR</strong>. There are animal data 273 and some observational clinicaldata indicating an association between high SaO 2 after ROSCand worse outcome. 274 Initially, give the highest possible oxygenconcentration. As soon as the arterial blood oxygen saturation canbe measured reliably, by pulse oximeter (SpO 2 ) or arterial bloodgas analysis, titrate the inspired oxygen concentration to achievean arterial blood oxygen saturation in the range of 94–98%.Alternative airway devices versus tracheal intubationThere is insufficient evidence to support or refute the use ofany specific technique to maintain an airway and provide ventilationin adults with cardiopulmonary arrest. Despite this, trachealintubation is perceived as the optimal method of providing andmaintaining a clear and secure airway. It should be used onlywhen trained personnel are available to carry out the procedurewith a high level of skill and confidence. There is evidence that,without adequate training and experience, the incidence of complications,is unacceptably high. 275 In patients with out-of-hospitalcardiac arrest the reliably documented incidence of unrecognisedoesophageal intubation ranges from 0.5% to 17%: emergency physicians– 0.5% 276 ; paramedics – 2.4%, 277 6%, 278,279 9%, 280 17%. 281Prolonged attempts at tracheal intubation are harmful; stoppingchest compressions during this time will compromise coronaryand cerebral perfusion. In a study of prehospital intubation byparamedics during 100 cardiac arrests, the total duration of theinterruptions in <strong>CPR</strong> associated with tracheal intubation attemptswas 110 s (IQR 54–198 s; range 13–446 s) and in 25% the interruptionswere more than 3 min. 282 Tracheal intubation attemptsaccounted <strong>for</strong> almost 25% of all <strong>CPR</strong> interruptions. Healthcare personnelwho undertake prehospital intubation should do so onlywithin a structured, monitored programme, which should includecomprehensive competency-based training and regular opportunitiesto refresh skills. Personnel skilled in advanced airwayConfirmation of correct placement of the tracheal tubeUnrecognised oesophageal intubation is the most serious complicationof attempted tracheal intubation. Routine use of primaryand secondary techniques to confirm correct placement of the trachealtube should reduce this risk. Primary assessment includesobservation of chest expansion bilaterally, auscultation over thelung fields bilaterally in the axillae (breath sounds should be equaland adequate) and over the epigastrium (breath sounds shouldnot be heard). Clinical signs of correct tube placement are notcompletely reliable. Secondary confirmation of tracheal tube placementby an exhaled carbon dioxide or oesophageal detection deviceshould reduce the risk of unrecognised oesophageal intubation butthe per<strong>for</strong>mance of the available devices varies considerably andall of them should be considered as adjuncts to other confirmatorytechniques. 284 None of the secondary confirmation techniques willdifferentiate between a tube placed in a main bronchus and oneplaced correctly in the trachea.The accuracy of colorimetric CO 2 detectors, oesophageal detectordevices and non-wave<strong>for</strong>m capnometers does not exceed theaccuracy of auscultation and direct visualization <strong>for</strong> confirmingthe tracheal position of a tube in victims of cardiac arrest.Wave<strong>for</strong>m capnography is the most sensitive and specific wayto confirm and continuously monitor the position of a trachealtube in victims of cardiac arrest and should supplement clinicalassessment (auscultation and visualization of tube through cords).Existing portable monitors make capnographic initial confirmationand continuous monitoring of tracheal tube position feasible inalmost all settings, including out-of-hospital, emergency department,and in-hospital locations where intubation is per<strong>for</strong>med. Inthe absence of a wave<strong>for</strong>m capnograph it may be preferable to usea supraglottic airway device when advanced airway managementis indicated.www.elsuapdetodos.com<strong>CPR</strong> techniques and devicesAt best, standard manual <strong>CPR</strong> produces coronary and cerebralperfusion that is just 30% of normal. 285 Several <strong>CPR</strong> techniquesand devices may improve haemodynamics or short-term survivalwhen used by well-trained providers in selected cases. However,the success of any technique or device depends on the educationand training of the rescuers and on resources (including personnel).In the hands of some groups, novel techniques and adjuncts maybe better than standard <strong>CPR</strong>. However, a device or technique whichprovides good quality <strong>CPR</strong> when used by a highly trained team orin a test setting may show poor quality and frequent interruptionswhen used in an uncontrolled clinical setting. 286 While no circulatoryadjunct is currently recommended <strong>for</strong> routine use instead ofmanual <strong>CPR</strong>, some circulatory adjuncts are being routinely used inboth out-of-hospital and in-hospital resuscitation. It is prudent that
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