IFCPAR AR (ENGLISH) for CD - CEFIPRA

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CEFIPRA Centre Franco-Indien pour la Promotion de la Recherche Avancée Duration: Three years (September, 2010 to August, 2013) Objectives The collaborators will describe the Cannon-Thurston map in terms of the ending laminations. When (M,P) is the product of a surface S with boundary by an interval, the set of the closed geodesics for an hyperbolic on (M,P) which are shorter than the Margulis constant form a link in M. It is planned to study this link and try to relate it to the end invariants. Study the lines of minima of Steven Kerckhoff which are defined as the set of points s(t) in the Teichmuller space T(S) where the lamination l+tl' has shortest length when t varies over the positive reals. In particular, how this line extends to the Quasi- Fuchsian space (viewed as the complexication of Teichmuller space) Extend the Theorem of Bonahon on the Quasi-Fuchsian space to the space of metrics on an acylindrical hyperbolic manifold M necessary and sufficient conditions for a sequence of convex cocompact Kleinian groups to converge to a point in the boundary of their deformation space. Such conditions can be expressed either in terms of the behaviour of the bending measured geodesic laminations or in terms of the behaviour of the conformal structures at infinity. Accomplishments i) Description of Cannon-Thurston maps completed ii) Negative answer obtained to good analytical properties of Cannon-Thurston maps in general iii) Negative answer obtained to existence of Cannon-Thurston maps for higher rank symmetric spaces in general iv) Pattern Rigidity project completed Research papers published: One Papers presented in conferences: 5 Project 4301-1 KLEINIAN GROUPS: GEOMETRICAL AND ANALYTICAL ASPECTS Research Activities 2010-11 Pure and Applied Mathematics Dr. Mahan Mj School of Mathematical Sciences, RKM Vivekananda University West Bengal Prof. Jean-Pierre Otal Laboratoire Emile Picard Université Paul Sabatier Toulouse 33
34 Life and Health Sciences Dr. Saumitra Das Department of Microbiology and Cell Biology Indian Institute of Science Bangalore Dr. Robin Fahraeus Institut de Pharmacologie INSERM 940 Paris Project 3703-1 STUDIES ON THE REGULATION OF p53 mRNA TRANSLATION IFCPAR Indo-French Centre for the Promotion of Advanced Research Duration: Three years and nine months(August, 2007 to April, 2011) Objectives The tumor suppressor protein p53 plays multiple integral functions in the cell via controlling expression of multitude of downstream genes involved in cell cycle arrest and apoptosis. Thus, the level of the protein and its isoforms should be tightly regulated under both normal physiological as well as stress conditions. The project aims to study the regulation of p53 mRNA translation at the level of initiation. The specific objectives are: i) Characterization of the internal ribosome entry sites within p53 mRNA ii) Characterization of p53 mRNA translation control by the E3 ubiqutin ligase Mdm2 Accomplishments i) The Mdm2 protein binds directly to the p53 mRNA to induce p53 synthesis. This is the first report on E3 ligase binding an mRNA and controlling translation ii) The Mdm2- p53 mRNA interaction requires Mdm2 to be phosphorylated on Ser395. This site is phosphorylated by ATM and links the DNA damage response with Mdm2, p53 synthesis and activation iii) The p53/47 product is induced by PERK in response to the unfolded protein response (UPR) and is required for endoplasmic reticulum (ER) stress-induced G2 arrest iv) Polypyramidine tract binding protein (PTB) acts as a transacting factor for p53 mRNA translation and relative abundance of PTB in the cytoplasm differentially regulates IRES-mediated translation of the p53 isoforms v) hnRNP C1/C2 differentially regulates synthesis of p53 and p53/47 isoforms Research papers published: Four Papers presented in conference: 15 Poster: 17
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