IFCPAR AR (ENGLISH) for CD - CEFIPRA
IFCPAR AR (ENGLISH) for CD - CEFIPRA
IFCPAR AR (ENGLISH) for CD - CEFIPRA
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<strong>CEFIPRA</strong><br />
Centre Franco-Indien pour la Promotion de la Recherche Avancée<br />
Duration: Three years (February, 2010 to January, 2013)<br />
Objectives<br />
i) Design and synthesis of multidenate ligands to stabilize a<br />
dimetal core. Naphthyridine and N-heterocycliccarbene(NHC)<br />
based ligands will be designed to span two<br />
metals in proximity providing specific sites <strong>for</strong> organic<br />
substrates to interact. Ef<strong>for</strong>ts will be made to incorporate<br />
stereodirecting groups in the ligand <strong>for</strong> asymmetric<br />
trans<strong>for</strong>mation<br />
ii) Synthesis of diruthenium and dipalladium precursors.<br />
Pre<strong>for</strong>med dimetal precursors are desired <strong>for</strong> accessing<br />
dimetal catalysts. Protocols will be developed to assemble<br />
two metal ions in proximity starting from mono-metal<br />
precursors. Discrete and stable dipalladium and<br />
diruthenium complexes will be synthesized incorporating<br />
kinetically inert ligands to maintain structural integrity of<br />
the dimetal core throughout the course of the reaction and<br />
labile ligands to be replaced by organic reagents<br />
iii) Studies on the interaction of C-H bond with dimetal core,<br />
stoichiometric organometallic reactions at the dimetal<br />
plat<strong>for</strong>m, organometallic catalysis employing diruthenium<br />
and dipalladium complexes <strong>for</strong> a variety of reactions<br />
including cross-coupling reaction: Suzuki, Sonogashira,<br />
Negishi, Heck reaction. Special attention will be given to<br />
C-H bond activation/functionalization reactions of heteroaromatics,<br />
which are important building blocks in organic<br />
synthesis.<br />
Accomplishments<br />
i) A diruthenium(I) compound has been shown to catalyse<br />
aldehyde olefination reactions effectively<br />
ii) A set of diruthenium(I) compound with NHC ligands are<br />
shown to catalyse carbene-transfer reactions<br />
iii) Palladium-catalyzed direct arylation of thiophenes bearing<br />
SO R substituents have been demonstrated<br />
2<br />
iv) Dipalladium(II) compounds bridged by proline-based<br />
chiral ligand have been synthesized<br />
v) Non-classical carbene compound of Ru(II) have been<br />
synthesized.<br />
Research papers published: Three<br />
Project 4205-1<br />
BIMETALLIC CATALYSIS INVOLVING RUTHENIUM AND<br />
PALLADIUM: C-H BOND ACTIVATION/FUNCTIONALIZATION<br />
AND BEYOND<br />
Research Activities 2010-11<br />
Pure & Applied Chemistry<br />
Dr. Jitendra K. Bera<br />
Department of Chemistry<br />
Indian Institute of Technology<br />
Kanpur<br />
Dr. Henri Doucet<br />
Institut Sciences Chimiques de Rennes,<br />
UMR 6226, CNRS-Université de Rennes<br />
"Catalyse et Organometalliques"<br />
Rennes<br />
61
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