Guidelines on the Prevention and Control of Tuberculosis in Ireland

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<strong>Guidelines</strong> on the Prevention and Control of Tuberculosis in Ireland 2010HSE/HPSCAppendix 7: Contact details for clinical and laboratory TB adviceRespiratory PhysiciansDr Tim McDonnell, St Vincent’s University Hospital, DublinDr Brendan Keogh, Mater Misericordiae Hospital, DublinDr Terry O Connor, Mercy University Hospital, CorkDr JJ Gilmartin, University College Hospital, GalwayInfectious disease PhysiciansDr C. Fleming, University College Hospital, GalwayDr Karina Butler, Our Lady’s Hospital, Crumlin, DublinConsultant MicrobiologistsDr Margaret Hannan, Mater Misericordiae Hospital, DublinDr Bartley Cryan, Cork University HospitalIrish Mycobacteria Reference LaboratoryMr Noel Gibbons, Chief Medical Scientist, (01) 416 2963, ngibbons@stjames.ieProf T Rogers, Clinical Director, (01) 896 2131, rodgerstr@tcd.ieDr J Keane, Consultant Respiratory Physician, (01) 410 3920, jkeane@stjames.ieWebpage: www.stjames.ie/Departments/DepartmentsA-Z/I/IMRL/DepartmentOverview/or go to www.stjames.ie choose Lab services and then Irish Mycobacteria Reference LaboratoryAntimicrobial Reference Laboratory,Department of Medical Microbiology,North Bristol NHS Trust,Southmead Hospital,Bristol BS10 5NB,United KingdomThe Antimicrobial Reference Laboratory user manual may be found at www.bris.ac.uk/bcare/AssayBooklet.docResults and general inquiries: Tel. No: 00-44-117-959-5653Service EnquiriesProf A. P. MacGowan, Consultant Medical Microbiologist. Contact telephone no: 0044- 117-959-5652Email address: alasdair.macgowan@nbt.nhs.ukDr. A. M. Lovering, Consultant Clinical Scientist. Contact telephone no: 0044-117-959 5653Email address: andrew.lovering@nbt.nhs.ukMr. H. A. Holt, Laboratory Manager. Contact telephone no: 0044-117-959-5658Email address: alan.holt@nbt.nhs.uk-167-
<strong>Guidelines</strong> on the Prevention and Control of Tuberculosis in Ireland 2010HSE/HPSCAppendix 8: International Standards for Tuberculosis CareIn 2006 the “International Standards for Tuberculosis Care” were published to describe a widely acceptedlevel of care that all practitioners, public and private should seek to achieve in managing patients who haveor are suspected of having tuberculosis. The standards are outlined below. The full document is available atwww.who.int/tb/publications/2006/istc_report.pdf.Standards for DiagnosisStandard 1. All persons with otherwise unexplained productive cough lasting two to three weeks or moreshould be evaluated for tuberculosis.Standard 2. All patients (adults, adolescents, and children who are capable of producing sputum)suspected of having pulmonary tuberculosis should have at least two and preferably three, sputumspecimens obtained for microscopic examination. When possible, at least one early morning specimenshould be obtained.Standard 3. For all patients (adults, adolescents, and children) suspected of having extrapulmonarytuberculosis, appropriate specimens from the suspected sites of involvement should be obtained formicroscopy and, where facilities and resources are available, for culture and histopathological examination.Standard 4. All persons with chest radiographic findings suggestive of tuberculosis should have sputumspecimens submitted for microbiological examination.Standard 5. The diagnosis of sputum smear-negative pulmonary tuberculosis should be based on thefollowing criteria: at least three negative sputum smears (including at least one early morning specimen),chest radiography findings consistent with tuberculosis and lack of response to a trial of broad spectrumantimicrobial agents. (Note: Because the fluoroquinolones are active against M. tuberculosis complex andthus may cause transient improvement in persons with tuberculosis, they should be avoided.) For suchpatients, if facilities for culture are available, sputum cultures should be obtained. In persons with known orsuspected HIV infection, the diagnostic evaluation should be expedited.Standards for TreatmentStandard 6. The diagnosis of intrathoracic (i.e. pulmonary, pleural, and mediastinal orhilar lymph node) tuberculosis in symptomatic children with negative sputum smears should be based onthe finding of chest radiographic abnormalities consistent with tuberculosis and either a history of exposureto an infectious case or evidence of tuberculosis infection (positive TST or interferon gamma releaseassay). For such patients, if facilities for culture are available, sputum specimens should be obtained (byexpectoration, gastric washings, or induced sputum) for culture.Standard 7. Any practitioner treating a patient for tuberculosis is assuming an importantpublic health responsibility. To fulfill this responsibility the practitioner must not only prescribe anappropriate regimen but, also, be capable of assessing the adherence of the patient to the regimen andaddressing poor adherence when it occurs. By so doing, the provider will be able to ensure adherence tothe regimen until treatment is completed.Standard 8. All patients (including those with HIV infection) who have not been treatedpreviously should receive an internationally accepted first-line treatment regimen using drugs of knownbioavailability. The initial phase should consist of two months of isoniazid, rifampicin, pyrazinamide, andethambutol. The preferred continuation phase consists of isoniazid and rifampicin given for four months.Isoniazid and ethambutol given for six months is an alternative continuation phase regimen that may beused when adherence cannot be assessed, but it is associated with a higher rate of failure and-168-
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Guidelines on the Prevention and Control of Tuberculosis in Ireland

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