11.07.2015 Views

Guidelines on the Prevention and Control of Tuberculosis in Ireland

Guidelines on the Prevention and Control of Tuberculosis in Ireland

Guidelines on the Prevention and Control of Tuberculosis in Ireland

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

<str<strong>on</strong>g>Guidel<strong>in</strong>es</str<strong>on</strong>g> <strong>on</strong> <strong>the</strong> Preventi<strong>on</strong> <strong>and</strong> C<strong>on</strong>trol <strong>of</strong> <strong>Tuberculosis</strong> <strong>in</strong> Irel<strong>and</strong> 2010HSE/HPSCSputum smear positive TBThe revised WHO def<strong>in</strong>iti<strong>on</strong> <strong>of</strong> a new sputum smear positive pulm<strong>on</strong>ary TB case is based <strong>on</strong> <strong>the</strong> presence<strong>of</strong> at least <strong>on</strong>e acid fast bacillus (AFB+) <strong>in</strong> at least <strong>on</strong>e sputum sample <strong>in</strong> countries with a well functi<strong>on</strong><strong>in</strong>gexternal quality assurance (EQA) system <strong>in</strong> <strong>the</strong>ir laboratories. 24Sputum smear negative TBA sputum smear negative patient has:• At least three negative sputum smears (<strong>in</strong>clud<strong>in</strong>g at least <strong>on</strong>e early morn<strong>in</strong>g specimen)• Chest X-ray f<strong>in</strong>d<strong>in</strong>gs c<strong>on</strong>sistent with TB <strong>and</strong>• Lack <strong>of</strong> resp<strong>on</strong>se to a trial <strong>of</strong> broad-spectrum antimicrobial agents (Note: because <strong>the</strong>fluoroqu<strong>in</strong>ol<strong>on</strong>es are active aga<strong>in</strong>st M. tuberculosis complex <strong>and</strong> thus may cause transientimprovement <strong>in</strong> pers<strong>on</strong>s with TB, <strong>the</strong>y should be avoided). 25It should be noted that <strong>in</strong> mak<strong>in</strong>g a diagnosis <strong>of</strong> sputum smear negative TB based <strong>on</strong> <strong>the</strong> above threecriteria, a cl<strong>in</strong>ician who decides to treat with a full course <strong>of</strong> anti-TB chemo<strong>the</strong>rapy should report thisas a case <strong>of</strong> sputum smear negative pulm<strong>on</strong>ary TB to <strong>the</strong> MOH. Although <strong>the</strong> results <strong>of</strong> culture maynot be available until after a decisi<strong>on</strong> to beg<strong>in</strong> treatment has to be made, treatment should be stoppedsubsequently if cultures are negative, <strong>the</strong> patient has not resp<strong>on</strong>ded cl<strong>in</strong>ically <strong>and</strong> <strong>the</strong> cl<strong>in</strong>ician has soughto<strong>the</strong>r evidence <strong>in</strong> pursu<strong>in</strong>g <strong>the</strong> differential diagnosis. 25TB outbreaksThe follow<strong>in</strong>g are examples <strong>of</strong> situati<strong>on</strong>s to report:1. An unexpected <strong>in</strong>crease (significantly above basel<strong>in</strong>e) <strong>of</strong> newly identified c<strong>on</strong>firmed or suspectedcases <strong>in</strong> any sett<strong>in</strong>g2. Two or more TB cases <strong>on</strong> treatment from a c<strong>on</strong>gregate (e.g. school or pris<strong>on</strong>) or high risk sett<strong>in</strong>ge.g. HIV positive <strong>in</strong>dividuals occurr<strong>in</strong>g with<strong>in</strong> a relatively short space <strong>of</strong> time3. Three or more TB cases <strong>on</strong> treatment <strong>in</strong> a household4. Three or more cases <strong>on</strong> treatment from a community sett<strong>in</strong>g (outside a household) occurr<strong>in</strong>g with<strong>in</strong>a relatively short period <strong>of</strong> time who may be related5. Two or more cases <strong>of</strong> MDR-TB or XDR-TB that may be related <strong>and</strong> occur outside a household.When assess<strong>in</strong>g whe<strong>the</strong>r a cluster <strong>of</strong> TB cases represents an outbreak, <strong>in</strong>dicators to look for <strong>in</strong>clude:• Epidemiological l<strong>in</strong>ks between cases• Similar unique characteristics am<strong>on</strong>g cases• Match<strong>in</strong>g drug resistance patterns <strong>of</strong> isolates• Match<strong>in</strong>g DNA f<strong>in</strong>gerpr<strong>in</strong>t patterns <strong>of</strong> isolates.Outbreaks <strong>of</strong> particular c<strong>on</strong>cern are MDR-TB or XDR-TB outbreaks, outbreaks am<strong>on</strong>g immunocompromisedpopulati<strong>on</strong>s, children or o<strong>the</strong>r vulnerable groups.1.5 Notificati<strong>on</strong> ProceduresOnce a diagnosis <strong>of</strong> TB is ei<strong>the</strong>r laboratory c<strong>on</strong>firmed or str<strong>on</strong>gly suspected <strong>on</strong> cl<strong>in</strong>ical grounds, <strong>the</strong> MOHshould be notified by <strong>the</strong> cl<strong>in</strong>ical director <strong>of</strong> a diagnostic laboratory <strong>and</strong>/or cl<strong>in</strong>ician as so<strong>on</strong> as possible<strong>and</strong> ideally at <strong>the</strong> time <strong>of</strong> diagnosis (appendix 2). Infecti<strong>on</strong> preventi<strong>on</strong> <strong>and</strong> c<strong>on</strong>trol staff or o<strong>the</strong>r laboratorymedical or scientific staff to whom <strong>the</strong> functi<strong>on</strong> <strong>of</strong> provid<strong>in</strong>g notificati<strong>on</strong> <strong>of</strong> <strong>in</strong>fectious diseases has beendelegated by <strong>the</strong> cl<strong>in</strong>ician/cl<strong>in</strong>ical director <strong>of</strong> <strong>the</strong> laboratory may notify <strong>the</strong> case (s) also if authorised to doso by <strong>the</strong> cl<strong>in</strong>ician. Notificati<strong>on</strong> should be made us<strong>in</strong>g <strong>the</strong> <strong>in</strong>fectious disease notificati<strong>on</strong> form available at:www.hpsc.ie/hpsc/NotifiableDiseases/Notificati<strong>on</strong>Forms/.-7-

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!