Relevance of Sperm DNA Fragmentation - eshre
Relevance of Sperm DNA Fragmentation - eshre
Relevance of Sperm DNA Fragmentation - eshre
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Conclusions I• Infertile men have higher DF than fertile men• <strong>Sperm</strong>s <strong>of</strong> infertile men are more susceptible todamage age (ROS)• sperm with damaged <strong>DNA</strong> can successfullyfertilize - but may cause de novo mutations inthe <strong>of</strong>fspring. (despite the ability <strong>of</strong> the oocyteand embryo to repair some damage)→ causes concern about the safety <strong>of</strong> ICSI• Et Extensive DF might ihtnot tbe overcome by oocyterepair mechanisms.• Oocyte repair capacity cannot be measured.
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