Relevance of Sperm DNA Fragmentation - eshre
Relevance of Sperm DNA Fragmentation - eshre
Relevance of Sperm DNA Fragmentation - eshre
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2. Etiology <strong>of</strong> <strong>DNA</strong> Damagethe etiology <strong>of</strong> sperm <strong>DNA</strong> damage ismultifactorial• In the testis during the process <strong>of</strong>spermatogenesis:– Apoptosis: screening mechanisms,that mark individual apoptoticsperms which causes phagocytosis<strong>of</strong> these cells, failed (double sb)– during remodeling <strong>of</strong> spermchromatin the <strong>DNA</strong> is unwoundthrough the induction <strong>of</strong> strandbreaks (single sb), sperms withunrepaired strand breaks →semen.
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