Etudes sur le mécanisme de remodelage des nucléosomes par ...

tel-00413908, version 1 - 7 Sep 2009
well documented in various cellular processes including development, cell cycling and some
disease mainly carcinogenesis. A snapshot of functions of ATP-dependent chromatin
remodeling complexes is presented in Table I.1.
Table I.1 Biological functions of chromatin remodelers. Chromatin complexes carry out
various functions in different organisms. The table summarizes their functions in different
species. Sc, Saccharomyces cerevisiae; Dm, Drosophila melanogaster; Hs, Homo sapiens;
*Based on data from many species; At, Arabidopsis thaliana. Adapted from Saha et al., 2006.
Remodeling
Complex
SWI/SNF family
Sc SWI/SNF
Sc RSC
Dm Brahma
Hs SWI/SNF
ISWI-family
ISWI*
Dm ACF and
CHRAC
Biological functions References
Pol II activation
Elongation
Double strand break (DSB) repair
Targeting by activators
Pol II regulation
Pol III regulation
Cell signalling
Spindle-assembly checkpoint
Chromosome/plasmid segregation
Cohesion
DSB repair
Cell-cycle progression
Targeting by activators
Octamer transfer/ejection
Pol II regulation
Development
Elongation
Tumor suppressor
Differentiation
Development
Elongation
Signaling
Splicing
Elongation
Pol II repression
Replication
X-chromosome regulation
Cohesion
Embryonic development
Chromatin assembly
Nucleosome spacing
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Hirschhorn et al., 1992; Sudarsanam et al.,
2000.
Davie and Kane, 2000.
Chai et al., 2005.
Neely et al., 2002; Yudkovsky et al., 1999.
Ng et al., 2002; Angus-Hill et al., 2001;
Moreira and Holmberg, 1999.
Ng et al., 2002.
Angus-Hill et al., 2001; Damelin et al., 2002.
Angus-Hill et al., 2001.
Huang and Laurent 2004; Wong et al., 2002.
Huang et al., 2004.
Chai et al., 2005
Cao et al., 1997
Neely et al., 2002
Reinke and Horz, 2003; Boeger et al., 2004
Armstrong et al., 2002
Zraly et al., 2004; Marenda et al., 2003
Srinivasan S. et al., 2005
Roberts et al., 2000; Wong et al., 2000;
Hendricks et al., 2004.
Gresh L. et al., 2005; Vradii et al., 2006; de
la Serna et al., 2001a.
Bultman, S. et al.2000; Wang et al., 2004;
Lickert, et al., 2004.
Corey et al., 2003.
Zhao et al., 1998.
Batsche et al., 2006.
Morillon et al., 2003
Goldmark et al., 2000; Vary et al., 2003.
Bozhenok et al., 2002; Collins et al., 2002.
Deuring et al., 2000.
Hakimi et al., 2002.
Stopka and Skoultchi, 2003.
Ito et al., 1997; Varga-Weisz et al., 1997;
Fyodorov and Kadonaga, 2002.
Varga-Weisz et al., 1997.
Dm NURF Transcriptional activation Badenhorst et al., 2002.