Beyond Bliss Streetc l a s s n o t e sYou were a young medicalstudent at AUB at <strong>the</strong>height <strong>of</strong> Lebanon’s civilwar. That must have beenquite challeng<strong>in</strong>g.The civil war started when Iwas <strong>in</strong> <strong>the</strong> sixth grade andwas at its height when I wasat AUB from 1981 to 1988.Grow<strong>in</strong>g up <strong>in</strong> an emergencywar situation can make youa lot more flexible <strong>in</strong> deal<strong>in</strong>gwith emergencies. I’m notimmobilized by unexpectedevents, which has served mewell <strong>in</strong> my career at CDCrespond<strong>in</strong>g to public heal<strong>the</strong>mergencies and deal<strong>in</strong>gwith global health issues.How did your <strong>in</strong>terest <strong>in</strong>epidemiology or <strong>in</strong>fectiousdiseases orig<strong>in</strong>ate?I’ve always been <strong>in</strong>terested<strong>in</strong> public health, but my <strong>in</strong>terestreally took root dur<strong>in</strong>gmy residency and fellowshipat Emory <strong>University</strong>. I wasgett<strong>in</strong>g somewhat frustratedRana Hajjeh (BS ’84,MD ’88) is director <strong>of</strong><strong>the</strong> Division <strong>of</strong> BacterialDiseases at <strong>the</strong> UnitedStates Centers for DiseaseControl and Prevention(CDC)’s National Centerfor Immunizations andRespiratory Diseases. Aworld renowned epidemiologistwho spends asmuch time <strong>in</strong> <strong>the</strong> field as<strong>in</strong> <strong>the</strong> <strong>of</strong>fice, Hajjeh discussedher wide rang<strong>in</strong>gwork with Ma<strong>in</strong>Gate.with cl<strong>in</strong>ical medic<strong>in</strong>e and<strong>the</strong> fact that patients wererepeatedly com<strong>in</strong>g <strong>in</strong> withrecurrent medical conditionsthat could have been easilyprevented, so I signed onfor <strong>the</strong> two-year EpidemicIntelligence Service programat <strong>the</strong> CDC <strong>in</strong> 1993. It mademe a very firm believer <strong>in</strong>prevention and <strong>the</strong> importance<strong>of</strong> good public health.I now work on vacc<strong>in</strong>es,which are <strong>the</strong> ultimate prevention<strong>in</strong>tervention.Does your focus onvacc<strong>in</strong>es mean that you’rema<strong>in</strong>ly concerned withchildhood diseases?I tra<strong>in</strong>ed as an <strong>in</strong>ternist andan <strong>in</strong>fectious diseases specialist;my <strong>in</strong>terest is broadly<strong>in</strong> public health with a focuson <strong>in</strong>fectious diseases. Thevacc<strong>in</strong>es I work on noware also given to adults.Recently, my division playeda major role <strong>in</strong> <strong>in</strong>troduc<strong>in</strong>g<strong>the</strong> men<strong>in</strong>gococcal men<strong>in</strong>gitisvacc<strong>in</strong>es. Men<strong>in</strong>gococcaldisease causes horrible epidemics<strong>in</strong> what is called<strong>the</strong> African Men<strong>in</strong>gitis Belt,which is sub-SaharanAfrica. Our group helped todevelop <strong>the</strong> vacc<strong>in</strong>e and toprovide <strong>the</strong> <strong>in</strong>frastructurefor implementation at <strong>the</strong>country level. The new vacc<strong>in</strong>ewas recently launched<strong>in</strong> Burk<strong>in</strong>a Faso and isexpand<strong>in</strong>g to cover o<strong>the</strong>rcountries. It may soon elim<strong>in</strong>atemen<strong>in</strong>gitis epidemics <strong>in</strong><strong>the</strong> region.You’ve been all over <strong>the</strong>world from South Africa,Thailand, Vietnam, Peru,<strong>the</strong> Middle East…CDC is <strong>the</strong> national publichealth agency for <strong>the</strong> UnitedStates, but we also serve astechnical experts and consultantsfor <strong>the</strong> World HealthOrganization (WHO) and forvarious o<strong>the</strong>r countries whoappeal to <strong>the</strong> CDC for assistance.In 2001 <strong>the</strong>re wasa big outbreak <strong>of</strong> men<strong>in</strong>gococcalmen<strong>in</strong>gitis dur<strong>in</strong>g <strong>the</strong>Hajj. Be<strong>in</strong>g a Muslim, I was<strong>the</strong> only member <strong>of</strong> <strong>the</strong> CDCteam able to make it all <strong>the</strong>way to Mecca. It’s <strong>in</strong>terest<strong>in</strong>ghow my background asa Francophone <strong>in</strong> Haiti andas an Arabic speak<strong>in</strong>g <strong>in</strong>fectiousdiseases medical epidemiologist<strong>in</strong> Saudi Arabiahelped get me to <strong>the</strong> frontl<strong>in</strong>es. However, backgroundcan only take you so far. Itwas my tra<strong>in</strong><strong>in</strong>g <strong>in</strong> manag<strong>in</strong>glarge outbreaks that mademe part <strong>of</strong> <strong>the</strong> responseteam <strong>in</strong> <strong>the</strong> anthrax attacks<strong>in</strong> Wash<strong>in</strong>gton, DC <strong>in</strong> 2001.The fasc<strong>in</strong>at<strong>in</strong>g th<strong>in</strong>g aboutepidemiology is that you’renot only look<strong>in</strong>g at <strong>the</strong> cl<strong>in</strong>icaland pathological aspects<strong>of</strong> disease but also at <strong>the</strong><strong>in</strong>teraction with <strong>the</strong> environment,society, culture, andhuman behavior.Are global travel and <strong>the</strong>ease with which peoplemove around <strong>the</strong> worldnow lead<strong>in</strong>g to <strong>in</strong>fectionsspread<strong>in</strong>g more quickly?Yes. Two recent examplesare <strong>the</strong> 2003 SARS epidemic,which orig<strong>in</strong>ated <strong>in</strong>Hong Kong, and <strong>the</strong> H1N1<strong>in</strong>fluenza, which orig<strong>in</strong>ated<strong>in</strong> Mexico. They both spreadrapidly throughout <strong>the</strong> world.I was <strong>in</strong>volved <strong>in</strong> <strong>the</strong> Hotel“M” <strong>in</strong>vestigation—<strong>the</strong> hotel<strong>in</strong> Hong Kong where <strong>the</strong>first SARS case occurred.From one case <strong>the</strong> virusspread all over <strong>the</strong> worldwith<strong>in</strong> weeks. The Hajj men<strong>in</strong>gitisepidemic was due toa new stra<strong>in</strong> <strong>of</strong> <strong>the</strong> men<strong>in</strong>gitisorganism. Aga<strong>in</strong>, weeksafter <strong>the</strong> outbreak occurred<strong>in</strong> Mecca, small clustersbegan appear<strong>in</strong>g <strong>in</strong> variouscountries, <strong>in</strong>clud<strong>in</strong>g places <strong>in</strong>Europe and North Americaas pilgrims returned home.Microbes are like humans,<strong>the</strong>y keep evolv<strong>in</strong>g.62 Ma<strong>in</strong>Gate Fall 2011 | www.aub.edu.lb/ma<strong>in</strong>gate
Beyond Bliss Streetc l a s s n o t e sYou returned from acholera relief effort <strong>in</strong>Haiti last spr<strong>in</strong>g. What didyou see <strong>the</strong>re?They haven’t rebuilt anyth<strong>in</strong>gyet and <strong>the</strong>re are piles <strong>of</strong> rubblestill <strong>in</strong> <strong>the</strong> street. Waterand hygiene <strong>in</strong>frastructure isalmost nonexistent, whichsignificantly contributed to<strong>the</strong> rapid spread <strong>of</strong> <strong>the</strong> choleraepidemic. I had to stay<strong>in</strong> a tent on <strong>the</strong> US Embassygrounds for three weeksbecause <strong>the</strong>re aren’t manyhotels <strong>in</strong> Port au Pr<strong>in</strong>ce thatare safe enough to stay <strong>in</strong>. Interms <strong>of</strong> <strong>the</strong> cholera, people<strong>in</strong> refugee camps actuallyfared much better than peopleoutside because most<strong>of</strong> <strong>the</strong> refugee camps areoperated by relief organizationsand NGOs and <strong>the</strong>yprovide cleaner water thanis available to <strong>the</strong> rest <strong>of</strong> <strong>the</strong>country. In Haiti, especially <strong>in</strong>rural areas, people go to <strong>the</strong>rivers directly for everyth<strong>in</strong>g<strong>the</strong>y need. Until <strong>the</strong> <strong>in</strong>frastructure<strong>in</strong> Haiti is rebuiltso that people have accessto safe water, it will be verydifficult to control <strong>the</strong> choleraoutbreak completely and toprevent future outbreaks.Is <strong>the</strong>re a vacc<strong>in</strong>e forcholera?Cholera vacc<strong>in</strong>es are notvery effective. There’s a newone now, but it’s availableonly <strong>in</strong> limited quantities. Thema<strong>in</strong> <strong>in</strong>tervention is to educate<strong>the</strong> public about <strong>the</strong>importance <strong>of</strong> us<strong>in</strong>g cleanwater. They hadn’t had as<strong>in</strong>gle case <strong>of</strong> cholera <strong>in</strong>Haiti for 100 years, so <strong>the</strong>population was completelynaïve and vulnerable to <strong>the</strong>organism which spread veryquickly. Even <strong>the</strong> physiciansweren’t tra<strong>in</strong>ed because <strong>the</strong>yhad never seen a case <strong>of</strong>cholera.Are you see<strong>in</strong>g widergaps <strong>in</strong> public healthbetween developed andundeveloped countries?Some public health <strong>in</strong>terventionscan be costly. Indevelop<strong>in</strong>g countries it takesa lot more resources toimplement <strong>the</strong>m. New vacc<strong>in</strong>esthat deal with pneumoniaand diarrhea aremuch more expensive thanrout<strong>in</strong>e vacc<strong>in</strong>es, so <strong>the</strong>y’regenerally <strong>in</strong>troduced <strong>in</strong> <strong>the</strong>United States and o<strong>the</strong>r high<strong>in</strong>come countries at leastten years before <strong>the</strong>y makeit to low <strong>in</strong>come countries.However, <strong>the</strong>re are manyglobal efforts ongo<strong>in</strong>g rightnow to change this trend,such as <strong>the</strong> work done byGAVI [<strong>the</strong> Global <strong>All</strong>iance forVacc<strong>in</strong>es and Immunization].What makes you mosthopeful about <strong>the</strong> workyou do?I strongly believe that <strong>the</strong>implementation <strong>of</strong> publichealth <strong>in</strong>terventions is <strong>the</strong>way to better health for <strong>the</strong>world. You are literally sav<strong>in</strong>gthousands <strong>of</strong> lives as yougo. To see so many childrenhave access to life sav<strong>in</strong>g<strong>in</strong>terventions and feel<strong>in</strong>g thatI’ve played a part <strong>in</strong> that isextremely reward<strong>in</strong>g.—B.R.More On-l<strong>in</strong>ewww.aub.edu.lb/ma<strong>in</strong>gate | Ma<strong>in</strong>Gate Fall 2011 63