Familial Nasopharyngeal Carcinoma 6

Pathology of Nasopharyngeal Carcinoma 77Fig. 7.8. Undifferentiatedcarcinoma showingpositivity for cytokeratin(AE1/3) (immunoperoxidase,original magnification×200)Fig. 7.9. Undifferentiatedcarcinoma showing EBERpositivity by in situ hybridization(original magnification×400)7.3.3Role of Fine Needle Aspiration CytologyFine needle aspiration cytology (FNAC) is a convenient,minimally invasive, low-cost, and fairly accuratemethod to assess for the presence of NPC tumor cells(Viguer et al. 2005). The technique helps sample cellsfor diagnostic evaluation from sites of suspectedtumor involvement, most often the cervical lymphnodes. Hence, its functions are threefold: for the diagnosisof NPC, as an aid to initial tumor staging, and forthe confirmation of tumor recurrence or metastasis.