Familial Nasopharyngeal Carcinoma 6

Molecular Signaling Pathways in Nasopharyngeal Cancer 31Fig. 3.2. The Wnt/b-Catenin Signaling Pathways. (Diagram reproduced courtesy of Cell Signaling Technology, Inc. [www.cellsignal.com])progression in 78 NPC patients treated with definitiveradiation therapy on multivariate analysis (Maet al. 2003). These findings were similarly confirmedin a more recently published series. Chua et al. (2004)reported on the association between EGFR expressionand disease-specific survival, relapse-free survival,locoregional relapse-free, and distantmetastasis-free rates in 54 patients with stage III–IVNPC treated with induction chemotherapy and radiationtherapy: Those rates for patients with EGFRextent of > 25% were 48%, 36%, 60%, and 55%,respectively, when compared with 86%, 80%, 93%,and 86%, respectively, for EGFR extent