Familial Nasopharyngeal Carcinoma 6

256 W. I. Weicisplatin and 5-fluorouracil in recent years, hasimproved locoregional disease control (Lee et al.2005). The application of intensity-modulated radiotherapyalso resolves the target-volume issue anddose uncertainty at the primary tumor and the upperlymph nodes in the neck. They can be treated withone single volume throughout, resulting in bettertumor control (Kam et al. 2003).Despite these measures, recurrent carcinoma in theneck node is still observed. In a report published 20years ago on a large cohort of patients suffering fromall stages of NPC, the incidence of recurrent diseasein the neck following combined chemoradiation wasless than 5% (Hung et al. 1985). Recently, with theapplication of IMRT, isolated recurrence in the neckwas reported to be