Familial Nasopharyngeal Carcinoma 6

Prognostic Factors in Nasopharyngeal Cancer 115Results1. No significant impact of EGFR intensity on survival2. EGFR extent ³25% predicts poorer DSS, RFS, LRFFS (p < 0.05)3. Multivariate analysis: EGFR extent is the only independent factor for disease relapse, locoregional failure, cancer death1. Positive correlation of EGFR expression and poorer OS (p = 0.0001), DFS (p = 0.01), TTP (p = 0.0001)2. p53 expression predicts poor DFS (p = 0.01), TTP (p = 0.06)3. No prognostic effect of HER-2, Ki67, and MVD4. Multivariate analysis: only EGFR expression is significantly linked to shorter OS and TTP1. No significant impact of EGFR, Ki67, p53 on survival2. Intense MVD correlates with higher distant failure (p = 0.03), shorter OS (p = 0.02) and DFS (p = 0.05)3. Strong c-erbB 2expression correlated with shorter OS (p = 0.02) and DFS (p = 0.02)High MVD correlated with poor OS (p = 0.01)Ki67 0.05Expression of p53 had poor OS (p = 0.05)No significant correlation between p53 expression and radiotherapy response1. Loss of cyclin D1 (p = 0.015) and p16 (p = 0.047) correlated with poor local control2. No correlation of pRb with local control1. Complete absence of p16 expression predicts poor OS by multivariate analysis (p = 0.022)2. No correlation of pRb with survival3. Patients with EBER-positive have better OS by multivariate analysis (p = 0.005)1. Overexpression of c-myc correlated with a poor survival (p < 0.05)2. No correlation of ras with survivalPatients with positive c-kit predict better survival (p = 0.029)Higher CENP-H expression correlated with shorter OS by univariate (p = 0.021) and multivariate (p = 0.04) analysis1. Patients with aneuploidy tumors have significantly poor OS (p < 0.01)2. Patients with high SPF and PF correlated with poor OS (p < 0.004 and p < 0.0009)1. Aneuploidy tumors predict poor OS by univariate (p = 0.042) and multivariate (p = 0.052) analysis2. Tumors with high SPF have poor OS (p = 0.057)