Abstracts Poster Abstracts - Dr Falk

86Thrombocytosis as a prognostic factor in pancreatic cancer -Facts or fictionsS. Naumovski-Mihalic, B. Papa, M. Katicic, V. Colic-Cvrlje, H. Vrazic, M. Ticak,B. SabaricIntensive Unit Care, Dept. of Gastroenterology, University Hospital MERKUR,Medical School of Zagreb, Zagreb, CroatiaIntroduction: The purpose of this study was to determine the significance ofthrombocytosis as a prognostic factor in patients with pancreatic cancer (PC).Methods: There were 69 patients - 44M/25F with pancreatic cancer (44 resectable and25 unresectable cancers), mean age 62.5 yrs. The clinicopathologic factors studied forprognostic value were: gender, age, tumor size, pain, preoperative and postoperativelevels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9),metastases, the extent of weight lost and biochemical and morphological parameters.Platelet counts were recorded and any patients with at least one platelet count ofgreater than 450 x 10 9 /l was classified with thrombocytosis. A platelet count of 450 x10 9 /l were classified with a normal platelet count.Results: Thrombocytosis were found in 22/25 (88%) pts with unresectable PC, and in26/44 pts (59%) with resectable PC after operation (p < 0.001). In all patients withthrombocytosis were found very high level of CA 19-9 (76% vs. 35%) compared with ptswith normal platelet count (p < 0.001). Multiple metastases with pain and weight lostwere in 42/48 pts with thrombocytosis vs. 6/25 pts with normal platelet count (p