Abstracts Poster Abstracts - Dr Falk

95Endoscopic surveillance for hereditary non-polyposis colorectalcancer (HNPCC) familiesG. Riegler 1 , A. de Leone 1 , G.B. Rossi 2 , I. Esposito 1 , P. Marone 2 , A. Ursillo 1 ,G. Di Gregorio 1 , M.I. Russo 1 , M. de Bellis 21 U.O.C. di Gastroenterologia ed Endoscopia Digestiva-Seconda Università degli Studidi Napoli, Italy2 Dipartimento di Chirurgia-Istituto Nazionale dei Tumori, Fondazione G. Pascale, Napoli,ItalyIntroduction: The current guidelines for the endoscopic surveillance of members ofHNPCC families suggest a colonoscopy every 2 years for all the first degree relativesof the index case, starting at 25 years of age.Methods: We selected 11 families satisfying the Amsterdam criteria I and we collecteddata from 107 first degree relatives of 11 index cases. Of these, 15 died, 14 wereyounger than 25 years and 33 refused surveillance program. Eventually, 35 subjectswere enrolled in the endoscopic surveillance program, together with 10 index cases.Results: At the time of the first colonoscopy 26 out of 45 subjects had no colorectallesion; on the other hand, 19 subjects had 26 lesions at colonoscopy: 3 hyperplasticpolyps (HP), 11 low grade adenomas (LGD), 1 high grade adenomas (HGD) and 11cancer (K). Thirty-six out of 45 enrolled subjects underwent 127 colonoscopies with amedian interval of 23 months. Seventy-one endoscopies resulted negative, while 56colonoscopies, performed in 25 patients, had a total of 97 lesions: 4 inflammatorypolyps (IP), 38 HP, 43 LGD, 6 HGD and 6 K.The median interval between two positive endoscopies was 27.4 months for both IP(range 6-37) and HP (range 4-135), 33.6 months for LGD (range 4-168), 56.6 monthsfor HGD (range 4-168) and 20.5 months for K (range 9-48).Discussion/Conclusion: Our data suggest that our surveillance program is consistentwith the international guidelines for surveillance. Moreover, our results support thehypothesis of an increased neoplastic risk associated with hyperplastic polyps.