Abstracts Poster Abstracts - Dr Falk

9Pancreatic cancer in patients with chronic pancreatitis: Incidenceand risk factorsS.T. Barbu*, I. Lupu***IVth Surgical Clinic, **Social Medicine Unit, University of Medicine and Pharmacy "IuliuHatieganu" Cluj-Napoca, RomaniaIntroduction: Patients with chronic pancreatitis (CP) have an increased risk forpancreatic cancer (PCc), a malignancy with late diagnosis and fatal outcome.Purpose: To assess frequency and risk factors for PCc in our patients withnon-hereditary CP.Methods: We performed a retrospective record analysis and a subsequent prospectivefollow-up of 136 patients operated in our clinic between 1993 and 2002 fornon-hereditary CP. At laparotomy, 3 males (38, 51 and 56 years old) were found tohave ductal adenocarcinoma developed on CP (final tissue diagnosis). Standardizedincidence ratio (SIR) was calculated for 2121 patient years of follow-up. To find riskfactors for PCc, we applied a Pearson correlation test and a nonlinear estimation for thefollowing factors: age, sex, occupation, alcohol intake (dose, years of drinking), cigarettesmoking (number of cigarettes, years of smoking), coffee consumption, fat diet, CPduration, number of CP complications, presence of diabetes and calcifications. Forsignificant associations, relative risk (RR) was calculated.Results: SIR of PCc was 12.76. We found that male sex, cigarette smoking, fat diet, CPduration, alcoholic etiology and number of complications are strong risk factors for PC(p < 0.005). Factors association leads to higher RR.Discussion/Conclusion: CP is an independent risk factor for development of PCc. Wedescribe a new risk factor for PCc in patients with CP: number of previous CPcomplications requiring operation, which possibly accelerates dysplasia. Presence ofrisk factors in CP patients suggests the need for closer follow-up and an aggressivesurgical approach if malignancy is suspected.