ANZCA Bulletin June 2012 - final.pdf - Australian and New Zealand ...

advertisementCYKLOKAPRON solution for injection reduces peri- and postoperativeblood loss and the need for blood transfusion in adult patientsundergoing cardiac surgery, or total hip or total knee arthroplasty. 1,2So your good work won’t go down the drain.BEFORE PRESCRIBING, PLEASE REVIEW FULL PRODUCT INFORMATION AVAILABLEFROM PFIZER AUSTRALIA PTY LTD. MINIMUM PRODUCT INFORMATION CYKLOKAPRON ® (tranexamic acid,1000 mg/10 mL Solution for Injection) Indications: reduction of peri - and post-operative blood loss and the need for blood transfusion in adult cardiac surgery,total knee or hip arthroplasty. See full PI for complete list. Contraindications: history or risk of thrombosis, active thromboembolic disease, colour visiondisturbances, subarachnoid haemorrhage, hypersensitivity to tranexamic acid or other ingredients. Precautions: Do not use in haematuria, Concomitantlywith Factor IX Complex Concentrates or Anti-inhibitor Coagulant Concentrates, irregular menstrual bleeding, disseminated intravascular coagulation rapidinjection may cause dizziness and/or hypotension. Pregnancy Category B1, Use with caution in nursing mothers. See full PI for details. Adverse Effects:Common side effects: death, arrhythmia, cardiogenic shock, myocardial infarction, stroke, renal dysfunction/ impairment, renal failure, respiratory failure,DVT Serious but rare side effects: convulsions. See full PI for details. Dosage and Administration: Adult Cardiac Surgery: 15 mg/kg (pre-surgery),4.5 mg/kg/hr (during surgery), 0.6 mg/kg of this infusion dose may be added to heart-lung machine. Adult Total Knee (TKA) or Hip Arthroplasty (THA):15 mg/kg prior to tourniquet release (TKA) or prior to skin incision (THA) & repeated at 8 & 16 hours after fi rst dose. Dosage adjustment in renal impairment,See full Product Information for dosage for other indications. The current Product Information is available at www.Pfi zer.com.au. PFIZER AUSTRALIA PTYLTD. ABN 50 008 422 348. 38-42 Wharf Road, West Ryde, NSW 2114. Pfi zer Medical Information 1800 675 229.®Registered trademark References: 1. CYKLOKAPRON Approved Product Information. 2. Henry DA et al. CochraneDatabase of Systematic Reviews 2011, Issue 3. Art. No. CD001886. McCann Healthcare P5181/CYK0046 11/11.PBS Information: This product is not listed on the PBS.