2006 merck/merial - School of Veterinary Medicine - Louisiana State ...

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Joseph Francis, B.V.Sc., M.V.Sc., Ph.D.Assistant Professor, Department of Comparative Biomedical SciencesLSU School of Veterinary Medicinejfrancis@lsu.eduResearch Interests:Dr. Francis’ research interest focuses on the role played by cytokines on pathophysiology of cardiovasculardisease. The overall objective of his research is to understand the brain mechanism regulating cardiovascularfunction with specific interest on the neurohormonal and cytokine influence on the progression of heart failure inrodents. Currently, Dr. Francis’ laboratory is involved in three primary projects. The first project examines theinteraction of cytokine with renin-angiotensin aldosterone system in heart failure. In the same project, he is alsoexamining the neurohumoral mechanism regulating cytokine expression in the brain after myocardial infarction.This study uses a combined electrophysiological, molecular and genetic approach to dissect the role played bycytokines in heart failure. The second project is to understand the forebrain mechanism regulating geneexpression in specific sympathoexcitatory neurons after myocardial infarction in rodents. This project uses genechip arrays and proteomics to elucidate the sympathoexcitatory genes. The third project is to understand the roleof cytokines in progression of diabetes with special emphasis on the brain mechanism contributing to insulinresistance. These studies will help in elucidating the role played by central nervous system in the progression ofheart failure and ultimately target the brain for the treatment of cardiovascular disease.Eric Lazartigues, Ph.D.Assistant ProfessorLSU Health Sciences CenterNew Orleans, LAelazar@lsuhsc.eduResearch Interests:Angiotensin-II (Ang-II) exerts its profound cardiovascular (CV) and volume homeostatic properties throughactivation of specific receptors, primarily Ang-II type 1 (AT1), located both in the periphery and in the brain.Evidence has shown the importance of the brain renin-angiotensin system (RAS) in the maintenance of normalblood pressure (BP) and in the development of hypertension. Although, new genetic and pharmacological toolshave improved our understanding of the global functioning of this system, the role of its different components andtheir interactions remain poorly understood due to the difficulty in experimentally dissecting brain versusperipheral RAS. Recently, a new element of the RAS, named ACE2, has been identified and is believed todegrade Ang-II to the vasodilator peptide angiotensin-1-7 (Ang 1-7 ). Very recently, Dr. Lazartigues identified thepresence of ACE2 in the brain and his interests focus on the role of this enzyme in modulating the activity of thebrain RAS during the development of neurogenic hypertension. Using non-transgenic (NT) and geneticallyengineeredmice in combination with molecular, physiological, and pharmacological tools, his laboratory isdedicated in assessing the relative physiological significance of central ACE2 in normal and pathophysiologicalregulation of BP and other CV diseases.Pamela Lucchesi, Ph.D.Associate ProfessorLSU Health Sciences CenterNew Orleans, LAplucch@lsuhsc.eduResearch Interests:A major research thrust in Dr. Lucchesi's laboratory is to understand how the complex interactions betweenhemodynamic forces, reactive oxygen/ nitrogen species and activation of signaling cascades lead to changes incardiovascular remodeling and function that underlie heart failure, hypertension and diabetes. A combination ofanimal disease models, in vivo measurements of blood flow, cardiac function (echocardiography and Millarpressure catheters), in situ measurements of vessel reactivity and myogenic tone, single cell functional analysis16
and biochemical, molecular and proteomic approaches are used to characterize disease progression. Projects inthe lab focus on: 1) oxidative stress and heart failure progression in response to hemodynamic overload; 2) role ofrenin angiotensin system and AGE/RAGE in coronary resistance artery remodeling in Type II diabetes; 3)activation of cell signaling in mesenteric resistance arteries in response to pressure and shear stress; and 4) role ofoxidative stress in cardiac functional and structural remodeling in response to drugs of abuse (collaboration withDr. Kurt Varner).Dr. Keith Strickland, D.V.M., DACVIM (Cardiology)Clinical Associate Professor, Department of Veterinary Clinical SciencesLSU School of Veterinary Medicinekstrick123@aol.comResearch Interests:Dr. Strickland received his B.S. in 1989 and his D.V.M. in 1993, both from Oklahoma State University. Dr.Strickland is a Diplomate of the American College of Veterinary Internal Medicine (Subspecialty ofCardiology)He is currently a Clinical Associate Professor in the Department of Veterinary Clinical Sciences at theLSU School of Veterinary Medicine and a veterinary cardiologist in the Schoolâ€s Veterinary TeachingHospital. He conducts 15 to 30 heart studies per week on patients ranging from cats and dogs to ferrets andhorses. Additionally, he is involved in research evaluating diagnostics for the assessment of cardiac function(such as Doppler tissue imaging) and therapies for congestive heart failure. Dr. Strickland conducted a studyfunded by the Doberman Pinscher Club of America that evaluated methods of early disease detectiond and riskstratification for patients that are at risk for developing dilated cardiomyopathy. Dr. Strickland also conducted aplacebo-controlled, double-blind drug study to see if a specific drug, pentoxifylline, can be used in addition toconventional therapy to treat dilated cardiomyopathy once it causes symptoms. Dr. Strickland plays an importantrole in the training of veterinary students and has been awarded the Outstanding Teacher of the Year multipletimes, as well as the Pfizer/Carl J. Norden Distinguished Teacher Award in 2005. Dr. Strickland has spoken atseveral national and international veterinary conferences, and is the featured speaker in cardiology for the 2006North American Veterinary Conference in Orlando, Florida.Kevin M. Kleinow, D.V.M., Ph.D.Professor, Department of Comparative Biomedical SciencesLSU School of Veterinary Medicinekleinow@vetmed.lsu.eduResearch Interests:Dr Kleinow's research interests center on mechanistic and applied aspects of aquatic animal toxicology,physiology and pharmacology. Focus areas include 1) biotransformation and transporter functions as modulatorsof xenobiotic bioavailability and excretion; 2) elaboration of basic mechanisms involved in the disposition ofcarcinogens, drugs and other xenobiotics in aquatic species; 3) the food chain transfer and consumption ofxenobiotics within and from the aquatic food chain; and 4) dispositional aspects of developmental toxicity.Glenna E. Mauldin, D.V.M., M.S., Diplomate, ACVIM (Oncology), ACVNAssociate Professor of Oncology, Cancer Treatment UnitLSU School of Veterinary Medicinegmauldin@vetmed.lsu.eduResearch Interests:As a board certified oncologist and nutritionist working in LSU’s Small Animal Hospital, Dr. Mauldin’s primaryresearch focus is the diagnosis and management of pet cats and dogs with cancer. She is particularly interested inthe relationship between cancer and nutrition, not only in terms of how nutrient excess or deficiency mightpredispose an animal to tumor development, but also with respect to the role nutrition plays in the treatment andsupport of cancer patients. Her recent work has examined the prevalence and causes of weight loss in cats and17
Page 1 and 2: 2006 MERCK/MERIALNATIONAL VETERINAR
Page 6 and 7: 3:00-3:30 pm BreakNovel therapy for
Page 8 and 9: KEYNOTE SPEAKERRonald Veazey, D.V.M
Page 10 and 11: Mini Symposium II:Fish Research: A
Page 12 and 13: David G. Baker, D.V.M., M.S., Ph.D.
Page 14 and 15: Konstantin G. Kousoulas, Ph.D.Profe
Page 18 and 19: dogs with cancer, the potential rol
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Page 22 and 23: YOUNG INVESTIGATOR AWARD HONORABLE
Page 24 and 25: Mammary epithelial-specific deletio
Page 28: Variation in Q-Tract Length of the
Page 34: Novel therapy for humoral hypercalc
Page 38: ALTERNATE:Micron-scale membrane sub
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Page 44 and 45: 19. A pilot study of cigarette smok
Page 46 and 47: 36. Development of a murine in vitr
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Page 52 and 53: 85. Age and Gender Influence Ventil
Page 58 and 59: 10. Preliminary estimation of risk
Page 62 and 63: 47. Osteoprotegerin and Receptor Ac
Page 64 and 65: 61. A Comparison of Interaction Pat
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ABSTRACT TITLES LISTED BY CATEGORY
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2006 MERCK/MERIALVETERINARY SCHOLAR
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used to label avian heterophils for
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obtained via analysis of time and d
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0.71mg/dL; p=0.001). Values for hem
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mass and fecundity in prespawning w
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Equine Hoof Laminae Tissue Collecti
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Aspiration Pneumonia in DogsDavid A
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Distortion Product Otoacoustic Emis
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tyrosine phosphorylation is measure
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the gravid and non-gravid females t
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egulatory function as its ortholog,
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PATHOLOGY, TOXICOLOGY, AND ONCOLOGY
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Markers of Oxidative Stress in plas
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has been isolated from all samples
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Matrix metalloproteinase secretion
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Reproductive performance, neonatal
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control to determine the efficiency
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Enhancing the Quality and Reliabili
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grade II MCTs into groups with good
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Transcriptional Regulation of the I
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MICROBIOLOGY AND IMMUNOLOGY (SESSIO
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colonization of the mutant and 6 re
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digestive tracts of these and other
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100 pfu BRSV. The results show that
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Inhibition of Microneme Secretion i
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Adherent bacilli were present in th
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isolated to analyze cytokine gene e
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purified, viral RNA was extracted a
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The effects of co-engagement of TLR
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Occurrence of Leptospira Vaccine Fa
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undifferentiated catecholaminergic
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the concept that the greater detoxi
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quantitative PCR using gene targets
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Rotenone Induced Dopamine Neuron De
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decrease in serum cortisol, with a
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and detrimental impacts on the brai
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actions of cells prior to embryo de
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Utilizing cDNA Subtraction to Exami
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expression in unilaterally pregnant
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Salmonella is increased. Poultry sa
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exports. The estimated prevalence o
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eeding grounds near Minnedosa, MB s
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(PBMC) were isolated using commerci
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Trainees acquire in-depth knowledge
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comparative pathology and/or resear
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Department of Veterinary Bioscience
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PhD, Director, Center for Comparati
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MICHIGAN STATEUNIVERSITYJames Crawf
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UNIVERSITY OFPENNSYLVANIALindsay Th
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