Epigenetics - LSUHSC Human Development Center

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Understanding genomicimprinting in embryogenesis• In mice, artificial generation of androgenote andgynogenote embryos by oocyte microinjectionand transfer.• Gynogenotes are produced in the lab byremoving fertilized oocytes from a female mouseprior to the fusion of the male and femalepronuclei• Androgenotes are made in a similar way, exceptthat the maternal-derived nucleus is removedand replaced with another male-derived nucleus
Pipetfertilized oocyteremove 1 nucleusPipetinject new nucleusPipetMaking a gynogenote(All genomic material from female germline)
Page 1: EpigeneticsFern Tsien, PhDDept. of
Page 5 and 6: Genomic imprinting
Page 7 and 8: Human Genomic Imprinting Map
Page 9: Genomic imprinting• Is necessary
Page 13 and 14: fertilized oocyte• Double-materna
Page 15 and 16: CONCLUSIONCompletion of embryogenes
Page 17 and 18: What controls epigenetics andgenomi
Page 19 and 20: ImprintestablishmentandpropagationI
Page 21 and 22: DNA MethylationCCDNA methylation re
Page 23 and 24: DNA methyl groups can directly inte
Page 25 and 26: DNA Methylation and CancerAbnormal
Page 27 and 28: DNA Methylation and CancerAbnormal
Page 29 and 30: Chromatin:DNA, Histones,and non-his
Page 31 and 32: Compaction of DNA• Histone protei
Page 33 and 34: HDAC inhibitors (HDI)• Trichostat
Page 35 and 36: Human Imprinting Map
Page 37 and 38: Angelman syndrome -AS• ‘Happy P
Page 39 and 40: Pathogenic mechanisms in PWS and AS
Page 41 and 42: Angelman syndromeIIIASP15PWSASPWS +
Page 43 and 44: How can epigenetics affectYOU????
Page 45 and 46: Epigenetics and environment• Phar
Page 47 and 48: Environment• A growing number of
Page 49 and 50: Identical twins:• Same genotype
Page 51 and 52: Epigenetics•These are two identic
Page 53: Thank you!!!!

Epigenetics - LSUHSC Human Development Center

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