Epigenetics - LSUHSC Human Development Center

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Global CpG methylation in humans• Postnatal somatic tissues are highlymethylated (~90%)• Term placenta (65%)• Sperm (70%)• The hypomethylation of placenta andsperm is due to the embryonic origin ofplacenta and the germline origin of sperm
DNA Methylation and CancerAbnormal Hypermethylation ofTumor suppressor genesTumor Suppressor genes are normallysupposed to be turned on or hypomethylatedto stop or suppress cancer.However, if they become abnormallyhypermethylated they can lead to humancancerNormal tumorsuppressor geneTranscriptional silencing of tumor suppressorgenes associated with DNA hypermethylationis a common epigenetic event in hematologicmalignancies (leukemias) and in early breastcancer.Tumor suppressorgene is turned offduring cancer
Page 1: EpigeneticsFern Tsien, PhDDept. of
Page 5 and 6: Genomic imprinting
Page 7 and 8: Human Genomic Imprinting Map
Page 9 and 10: Genomic imprinting• Is necessary
Page 11 and 12: Pipetfertilized oocyteremove 1 nucl
Page 13 and 14: fertilized oocyte• Double-materna
Page 15 and 16: CONCLUSIONCompletion of embryogenes
Page 17 and 18: What controls epigenetics andgenomi
Page 19 and 20: ImprintestablishmentandpropagationI
Page 21 and 22: DNA MethylationCCDNA methylation re
Page 23: DNA methyl groups can directly inte
Page 27 and 28: DNA Methylation and CancerAbnormal
Page 29 and 30: Chromatin:DNA, Histones,and non-his
Page 31 and 32: Compaction of DNA• Histone protei
Page 33 and 34: HDAC inhibitors (HDI)• Trichostat
Page 35 and 36: Human Imprinting Map
Page 37 and 38: Angelman syndrome -AS• ‘Happy P
Page 39 and 40: Pathogenic mechanisms in PWS and AS
Page 41 and 42: Angelman syndromeIIIASP15PWSASPWS +
Page 43 and 44: How can epigenetics affectYOU????
Page 45 and 46: Epigenetics and environment• Phar
Page 47 and 48: Environment• A growing number of
Page 49 and 50: Identical twins:• Same genotype
Page 51 and 52: Epigenetics•These are two identic
Page 53: Thank you!!!!

Epigenetics - LSUHSC Human Development Center

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