Epigenetics - LSUHSC Human Development Center
Epigenetics - LSUHSC Human Development Center
Epigenetics - LSUHSC Human Development Center
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DNA Methylation and CancerAbnormal Hypermethylation ofTumor suppressor genesTumor Suppressor genes are normallysupposed to be turned on or hypomethylatedto stop or suppress cancer.However, if they become abnormallyhypermethylated they can lead to humancancerNormal tumorsuppressor geneTranscriptional silencing of tumor suppressorgenes associated with DNA hypermethylationis a common epigenetic event in hematologicmalignancies (leukemias) and in early breastcancer.Tumor suppressorgene is turned offduring cancer