Epigenetics - LSUHSC Human Development Center
Epigenetics - LSUHSC Human Development Center
Epigenetics - LSUHSC Human Development Center
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Interconnecting folateand methyl metabolism•<strong>Human</strong>s ingestapproximately 50 mmol ofmethyl groups per day.**•****Folic acid is found in vegetables(broccoli, Brussels sprouts, spinach,etc).•Choline is mainly found in egg yolks,meat, and wheat germ•Of interest is the role offolate metabolism as amethyl source enablinghomocysteine to convert tomethionine, which in turnleads to the production ofSAM, the principal methyldonor and precursor forDNA methylation.Such a change is expectedto affect DNA methylationvia the concentrations ofSAM and SAH.
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