Epigenetics - LSUHSC Human Development Center

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Turning on of abnormallyinactivated tumor suppressorgenes5-aza-2′-deoxycytidine (also calledDecitabine) has both a hypomethylatingeffect at low doses when incorporated intoDNA and a cytotoxic effect at higher dosesas a result of interfering with translationwhen incorporated into RNA.Used for chemotherapy for leukemias.
DNA Methylation and CancerAbnormal Hypomethylation ofOncogenes•Oncogenes are normally turned on duringembryogenesis but are supposed to beturned off after birth and hypermethylatedwhen there is no need for such rapid cellgrowth.Abnormal turning on of these oncogenesthrough mutations or hypomethylation leadsto cancer.OncogeneduringembryogenesisOncogeneduringchildhood andadulthoodOncogene duringcancerMost human tumors often exhibit overallgenome hypomethylation relatively early invarious types of carcinogenesis
Page 1: EpigeneticsFern Tsien, PhDDept. of
Page 5 and 6: Genomic imprinting
Page 7 and 8: Human Genomic Imprinting Map
Page 9 and 10: Genomic imprinting• Is necessary
Page 11 and 12: Pipetfertilized oocyteremove 1 nucl
Page 13 and 14: fertilized oocyte• Double-materna
Page 15 and 16: CONCLUSIONCompletion of embryogenes
Page 17 and 18: What controls epigenetics andgenomi
Page 19 and 20: ImprintestablishmentandpropagationI
Page 21 and 22: DNA MethylationCCDNA methylation re
Page 23 and 24: DNA methyl groups can directly inte
Page 25: DNA Methylation and CancerAbnormal
Page 29 and 30: Chromatin:DNA, Histones,and non-his
Page 31 and 32: Compaction of DNA• Histone protei
Page 33 and 34: HDAC inhibitors (HDI)• Trichostat
Page 35 and 36: Human Imprinting Map
Page 37 and 38: Angelman syndrome -AS• ‘Happy P
Page 39 and 40: Pathogenic mechanisms in PWS and AS
Page 41 and 42: Angelman syndromeIIIASP15PWSASPWS +
Page 43 and 44: How can epigenetics affectYOU????
Page 45 and 46: Epigenetics and environment• Phar
Page 47 and 48: Environment• A growing number of
Page 49 and 50: Identical twins:• Same genotype
Page 51 and 52: Epigenetics•These are two identic
Page 53: Thank you!!!!

Epigenetics - LSUHSC Human Development Center

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