Epigenetics - LSUHSC Human Development Center

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Environment• A growing number of animal studies showthat parental diet and other exposures caninfluence fetal DNA methylation patternsand permanently affect health outcomes inlater life.• Environmentally induced changes in DNAmethylation patterns are heritable acrossgenerations• Twin studies
<strong>Epigenetics</strong> and environment• Pharmaceuticals, pesticides, air pollutants,industrial chemicals, heavy metals, hormones,and nutrition can change gene expressionthrough a broad array of gene regulatorymechanisms.• These chemically induced changes in generegulation are associated with serious andcomplex human diseases, including cancer,diabetes, infertility, respiratory diseases,allergies, and neurodegenerative disorders suchas Parkinson and Alzheimer diseases.• One of the best-studied areas of gene regulationis epigenetics, especially DNA methylation.
Page 1: EpigeneticsFern Tsien, PhDDept. of
Page 5 and 6: Genomic imprinting
Page 7 and 8: Human Genomic Imprinting Map
Page 9 and 10: Genomic imprinting• Is necessary
Page 11 and 12: Pipetfertilized oocyteremove 1 nucl
Page 13 and 14: fertilized oocyte• Double-materna
Page 15 and 16: CONCLUSIONCompletion of embryogenes
Page 17 and 18: What controls epigenetics andgenomi
Page 19 and 20: ImprintestablishmentandpropagationI
Page 21 and 22: DNA MethylationCCDNA methylation re
Page 23 and 24: DNA methyl groups can directly inte
Page 25 and 26: DNA Methylation and CancerAbnormal
Page 27 and 28: DNA Methylation and CancerAbnormal
Page 29 and 30: Chromatin:DNA, Histones,and non-his
Page 31 and 32: Compaction of DNA• Histone protei
Page 33 and 34: HDAC inhibitors (HDI)• Trichostat
Page 35 and 36: Human Imprinting Map
Page 37 and 38: Angelman syndrome -AS• ‘Happy P
Page 39 and 40: Pathogenic mechanisms in PWS and AS
Page 41 and 42: Angelman syndromeIIIASP15PWSASPWS +
Page 43: How can epigenetics affectYOU????
Page 47 and 48: Environment• A growing number of
Page 49 and 50: Identical twins:• Same genotype
Page 51 and 52: Epigenetics•These are two identic
Page 53: Thank you!!!!

Epigenetics - LSUHSC Human Development Center

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