Oral Presentations - Pathology and Laboratory Medicine - University ...

ResidentAhmad Al-Sarraf MD 1, 2 , Gautamn Sarwal, BMLSc 2, 3 , Catalin Taraboanta, MD MSc 1 ,and Jiri Frohlich, MD FRCP(C) 1,21Department of Pathology and Laboratory medicine, Faculty of Medicine, UBC 2 HealthyHeart Program Prevention Clinic, James Hogg iCAPTURE Centre for Cardiovascular andPulmonary Research 3 School of Medicine,MayneMedicalSchoolAhmad Al-Sarrafcharacterization of patients with very high plasmaHDL-cholesterol, with and without vascularpathologyAbstract # 40Backround/ObjectivesWhile epidemiological studies suggest that higher HDL-cholesterol (HDL-C) levels are antiatherogenic, very highlevels of HDL-C may not be atheroprotective. There may be a tendency to underestimate cardiovascular risk inpatients with very high HDL-C levels. We carried out a retrospective study of patients with HDL-C levels > 90thpercentile to assess their cardiovascular status/risk.Objective: To phenotype patients with very high plasma levels of HDL-C.MethodsMethods and ulation statistics, the cohort had a lower incidence of smoking and physical inactivity, higher moderatealcohol intake, infrequent obesity and a healthy diet. There was a surprisingly low incidence of Type 2 DiabetesMellitus (only two of 113 patients). A significant percentage of the patients had either evidence of cardiovasculardisorder or highFraminghamrisk score (FRS). 15 patients had a personal cardiovascular history: 6 had suffered MI, 1had positive stress test and 8 had carotid plaques. In addition, 16 had a FRS of greater than 20%.ConclusionVery high plasma levels of HDL-C in our cohort were associated with a healthy lifestyle and low incidence of diabetes.However, there was a significant number of individuals with preclinical or clinical vascular disease.Poster Presentations * 2 0 1 051