330 LO, TYRRELL, AND WILSON70. Miller DL, Doppman JL, Nieman LK, Cutler GB, Chrousos G,Loriaux DL, et al. Petrosal sinus sampling: Discordant lateralization<strong>of</strong> ACTH-secreting pituitary microadenomas before <strong>and</strong> afterstimulation with corticotropin-releasing hormone. Radiology1990;176:429–431.71. Wilson CB, Mindermann T, Tyrrell JB. Extrasellar, intracavernoussinus adrenocorticotropin-releasing adenoma causing Cushing’sdisease. J Clin Endocrinol Metab 1995;80:1774–1777.72. Teramoto A, Nemoto S, Takakura K, Sasaki Y, Machida T. Selectivevenous sampling directly from cavernous sinus in Cushing’ssyndrome. J Clin Endocrinol Metab 1993;76:637–641.73. Graham KE, Samuels MH, Nesbit GM, Cook DM, O’NeillOR, Barnwell SL, Loriaux DL. Cavernous sinus sampling ishighly accurate in distinguishing Cushing’s disease from theectopic adrenocorticotropin syndrome <strong>and</strong> in predictingintrapituitary tumor location. J Clin Endocrinol Metab 1999;84:1602–1610.74. Doppman JL, Nieman LK, Chang R, Yanovski J, Cutler GB,Chrousos GP, et al. Selective venous sampling from the cavernoussinuses is not a more reliable technique than sampling from theinferior petrosal sinuses in Cushing’s syndrome. J Clin EndocrinolMetab 1995;80:2485–2489.75. Samuels MH, Cook DM, O’Neill O, Nesbitt G, Barnwell S, LoriauxDL. Cavernous sinus sampling (CSS) is superior to inferior petrosalsinus sampling (IPSS) in the evaluation <strong>of</strong> Cushing’s syndrome.Presented at the 10th International Congress <strong>of</strong> Endocrinology,Abstract OR49-3. San Francisco, June 1996.76. Hardy J. Transphenoidal microsurgery <strong>of</strong> the normal <strong>and</strong> pathologicalpituitary. Clin Neurosurg 1969;16:185–217.77. Burch W. A survey <strong>of</strong> results with transsphenoidal surgery inCushing’s disease. N Engl J Med 1983;308:103–104.78. Wilson CB. A decade <strong>of</strong> pituitary microsurgery. J Neurosurg1984;61:814–833.79. Wilson CB, Dempsey LC. Transsphenoidal microsurgical removal<strong>of</strong> 250 pituitary adenomas. J Neurosurg 1978;48:13–22.80. Wilson CB. The long-term results following pituitary surgery forCushing’s disease <strong>and</strong> Nelson’s syndrome. In: Black PM, ZervasNT, Ridgway EC, Martin JB, eds. Secretory <strong>Tumors</strong> <strong>of</strong> the <strong>Pituitary</strong>Gl<strong>and</strong>. Raven, New York, 1984, pp. 287–294.81. L<strong>and</strong>olt AM, Schubiger O, Maurer, Girard J. The value <strong>of</strong> inferiorpetrosal sinus sampling in diagnosis <strong>and</strong> treatment <strong>of</strong> Cushing’sdisease. Clin Endocrinol (Oxford) 1994;40:485–492.82. Wilson CB, Tyrrell JB, Fitzgerald PA, Pitts LH. Cushing’s disease<strong>and</strong> Nelson’s syndrome. Clin Neurosurg 1980;27:19–30.83. McCance DR, Besser M, Atkinson AB. Assessment <strong>of</strong> cure aftertranssphenoidal surgery for Cushing’s disease. Clin Endocrinol(Oxford) 1996;44:1–6.84. Trainer PJ, Lawrie HS, Verhelst J, Howlett TA, Lowe DG,Grossman AB, Savage MO, et al. Transsphenoidal resection inCushing’s disease: Undetectable serum cortisol as the definition <strong>of</strong>successful treatment. Clin Endocrinol (Oxford) 1993;38:73–78.85. Bochicchio D, Losa M, Buchfelder M, et al. Factors influencingthe immediate <strong>and</strong> late outcome <strong>of</strong> Cushing’s disease treated bytranssphenoidal surgery: A retrospective study by the EuropeanCushing’s Disease Survey Group. J Clin Endocrinol Metab1995;80:3114–3120.86. McCance DR, Gordon DS, Fannin TF, Hadden DR, Kennedy L,Sheridan B, et al. Assessment <strong>of</strong> endocrine function after transsphenoidalsurgery for Cushing’s disease. Clin Endocrinol(Oxford) 1993;38:79–86.87. Friedman TC, Chrousos GP. Transsphenoidal resection in Cushing’sdisease: Definition <strong>of</strong> success. Clin Endocrinol (Oxford) 1993;39:701.88. Toms GC, McCarthy MI, Niven MJ, Orteu CH, King TT, MonsonJP. Predicting relapse after transsphenoidal surgery for Cushing’sdisease. J Clin Endocrinol Metab 1993;76:291–294.89. Arnott RD, Pestell RG, McKelvie PA, Henderson JK, McNeillPM, Alford FP. A critical evaluation <strong>of</strong> transsphenoidal pituitarysurgery in the treatment <strong>of</strong> Cushing’s disease: Prediction <strong>of</strong> outcome.Acta Endocrinol (Copenh) 1990;123:423–430.90. Jeffcoate WJ, Dauncey S, Selby C. Restoration <strong>of</strong> dexamethasonesuppression by incomplete adenomectomy in Cushing’s disease.Clin Endocrinol (Oxford) 1985;23:193–199.91. Avgerinos PC, Chrousos GP, Nieman LK, Oldfield EH, LoriauxDL, Cutler GB. The corticotropin-releasing hormone test in thepostoperative evaluation <strong>of</strong> patients with Cushing’s syndrome. JClin Endocrinol Metab 1987;65:906–913.92. Aron DC, Findling JW, Tyrrell JB. Cushing’s disease. EndocrinolMetab Clin North Am 1987;16(3):705–730.93. Lamberts SWJ, Klijn JGM, deJong FH. The definition <strong>of</strong> true recurrence<strong>of</strong> pituitary-dependent Cushing’s syndrome after transsphenoidaloperation. Clin Endocrinol (Oxford) 1987;26:707–712.94. Ram Z, Nieman LK, Cutler GB, Chrousos GP, Doppman JL,Oldfield EH. Early repeat surgery for persistent Cushing’s disease.J Neurosurg 1994;80:37–45.95. Sonino N, Zielezny M, Fava GA, Fallo F, Boscaro M. Risk factors<strong>and</strong> long-term outcome in pituitary-dependent Cushing’s disease.J Clin Endocrinol Metab 1996;81:2647–2652.96. Tindall GT, Herring CJ, Clark RV, Adams DA, Watts NB.Cushing’s disease: Results <strong>of</strong> transsphenoidal microsurgery withemphasis on surgical failures. J Neurosurg 1990;72:363–369.97. Robert F, Hardy J. Cushing’s disease: A correlation <strong>of</strong> radiological,surgical <strong>and</strong> pathological findings with therapeutic results.Pathol Res Pract 1991;187:617–621.98. Tahir AH, Sheeler LR. Recurrent Cushing’s disease after transsphenoidalsurgery. Arch Intern Med 1992;152:977–981.99. Olson BR, Rubino D, Gumowski J, Oldfield EH. Isolatedhyponatremia after transsphenoidal pituitary surgery. J ClinEndocrinol Metab 1995;80:85–91.100. Friedman RB, Oldfield EH, Nieman LK, Chrousos GP, DoppmanJL, Cutler GB, et al. Repeat transsphenoidal surgery for Cushing’sdisease. J Neurosurg 1989;71:520–527.101. Halberg FE, Sheline GE. Radiotherapy <strong>of</strong> pituitary tumors.Endocrinol Metab Clin North Am 1987;16(3):667–684.102. Orth DN, Liddle GW. Results <strong>of</strong> treatment in 108 patients withCushing’s syndrome. N Engl J Med 1971;285:243–247.103. Larson DA. Radiation therapy <strong>of</strong> pituitary tumors. In: YoumansJR, ed. Neurological Surgery. W.B. Saunders, Philadelphia, 1996,pp. 2970–2979.104. Flickinger JC, Rush SC. Linear accelerator therapy <strong>of</strong> pituitaryadenomas. In: L<strong>and</strong>olt AM, Vance ML, Reilly PL, eds. <strong>Pituitary</strong>Adenomas. Churchill-Livingstone, New Jersey, 1996, pp. 475–483.105. Howlett TA, Plowman PN, Wass JAH, Rees LH, Jones AE, BesserGM. Megavoltage pituitary irradiation in the management <strong>of</strong>Cushing’s disease <strong>and</strong> Nelson’s syndrome: Long-term follow-up.Clin Endocrinol (Oxford) 1989;31:309–323.106. Hughes MN, Llamas KJ, Yell<strong>and</strong> ME, Tripcony LB. <strong>Pituitary</strong> adenomas:Long-term results for radiotherapy alone <strong>and</strong> post-operativeradiotherapy. Int J Radiat Oncol Biol Phys 1993;27:1035–1043.107. Littley MD, Shalet SM, Beardwell CG, Ahmed SR, Sutton ML.Long-term follow-up <strong>of</strong> low-dose external pituitary irradiation forCushing’s disease. Clin Endocrinol (Oxford) 1990;33:445–455.108. Ahmed SR, Shalet SM, Beardwell CG, Sutton ML. Treatment <strong>of</strong>Cushing’s disease with low dose radiation therapy. Br Med J1984;289:643–646.109. Vincente A, Estrada J, de la Cuerda C, Astigarraga B, MarazuelaM, Blanco C, et al. Results <strong>of</strong> external pituitary irradiation afterunsuccessful transsphenoidal surgery in Cushing’s disease. ActaEndocrinol (Copenh) 1991;125:470–474.110. Estrada J, Boronat M, Mielgo M, Magallon R, Millan I, Diez S, etal. The long-term outcome <strong>of</strong> pituitary irradiation after unsuccessfultranssphenoidal surgery in Cushing’s disease. N Engl J Med1997;336:172–177.111. Clarke SD, Woo SY, Butler EB, Dennis WS, Lu H, Carpenter LS,et al. Treatment <strong>of</strong> secretory pituitary adenoma with radiationtherapy. Radiology 1993;188:759–763.112. Murayama M, Yasuda K, Minamori Y, Mercado-Asis LB,Yamakita N, Miura K. Long term follow-up <strong>of</strong> Cushing’s diseasetreated with reserpine <strong>and</strong> pituitary irradiation. J Clin EndocrinolMetab 1992;75:935–942.
CHAPTER 18 / CORTICOTROPH ADENOMAS 331113. Ross WM, Evered DC, Hunter P, Benaim M, Cook D, Hall R.Treatment <strong>of</strong> Cushing’s disease with adrenal blocking drugs <strong>and</strong>megavoltage therapy to the pituitary. Clin Radiol 1979;30:149–153.114. Snyder PJ, Fowble BF, Schatz NJ, Savino PJ, Gennarelli TA.Hypopituitarism following radiation therapy <strong>of</strong> pituitary adenomas.Am J Med 1986;81:457–462.115. Littley MD, Shalet SM, Beardwell CG, Ahmed SR, Applegate G,Sutton ML. Hypopituitarism following external radiotherapy forpituitary tumors in adults. Q J Med 1989;(70)262:145–160.116. Kjellberg RN, Kliman B, Swisher B, Butler W. Proton beamtherapy <strong>of</strong> Cushing’s disease <strong>and</strong> Nelson’s syndrome. In: BlackPM, Zervas NT, Ridgway EC, Martin JB, eds. Secretory <strong>Tumors</strong><strong>of</strong> the <strong>Pituitary</strong> Gl<strong>and</strong>. Raven, New York, 1984, pp. 294–307.117. Degerblad M, Rahn T, Bergstr<strong>and</strong> G, Thoren M. Long-term results<strong>of</strong> stereotactic radiosurgery to the pituitary gl<strong>and</strong> in Cushing’sdisease. Acta Endocrinol (Copenh) 1986;112:310–314.118. Rahn T, Thoren M, Werner S. Stereotactic radiosurgery in pituitaryadenomas. In: Faglia G, Beck-Peccoz P, Ambrosi B,Travaglini P, Spada A, eds. <strong>Pituitary</strong> Adenomas: New Trends inBasic <strong>and</strong> Clinical Research. Elsevier Science, New York, 1991pp. 303–312.119. Ganz JC. Gamma knife treatment <strong>of</strong> pituitary adenomas. In L<strong>and</strong>oltAM, Vance ML, Reilly PL, eds. <strong>Pituitary</strong> Adenomas. Churchill-Livingstone, New Jersey, 1996, pp. 461–474.120. S<strong>and</strong>ler LM, Richards NT, Carr DH, Mashiter K, Joplin GF. Longterm follow-up <strong>of</strong> patients with Cushing’s disease treated by interstitialirradiation. J Clin Endocrinol Metab 1987;65:441–447.121. Burke CW, Doyle FH, Joplin GF, Arnot RN, Macerlean DP, FraserTR. Cushing’s disease: Treatment by pituitary implantation <strong>of</strong>radioactive gold or yttrium seeds. Q J Med 1973;42(168):693–714.122. Pont A, Williams PL, Loose DS, Feldman D, Reitz RE, Bochra C,et al. Ketoconazole blocks adrenal steroid synthesis. Ann InternMed 1982;97:370–372.123. Sonino N. The use <strong>of</strong> ketoconazole as an inhibitor <strong>of</strong> steroid production.N Eng J Med 1987;317:812–818.124. Sonino N, Boscaro M, Merola G, Mantero F. Prolonged treatment<strong>of</strong> Cushing’s disease by ketoconazole. J Clin Endocrinol Metab1985;61:718–722.125. Engelhardt D, Weber MM. Therapy <strong>of</strong> Cushing’s syndrome withsteroid biosynthesis inhibitors. J Steroid Biochem Mol Biol1994;49:261–267.126. Trainer PJ, Besser M. Cushing’s syndrome: Therapy directed atthe adrenal gl<strong>and</strong>s. Endocrinol Metab Clin North Am 1994;23(3):571–584.127. Duarte PA, Chow CC, Simmons F, Ruskin J. Fatal hepatitis associatedwith ketoconazole therapy. Arch Intern Med 1984;144:1069–1070.128. Liddle GW, Estep HL, Kendall JW, Williams WC, Townes AW.Clinical application <strong>of</strong> a new test <strong>of</strong> pituitary reserve. J ClinEndocrinol Metab 1959;19:875–894.129. Jeffcoate WJ, Rees LH, Tomlin S, Jones AE, Edwards CRW,Besser GM. Metyrapone in long-term management <strong>of</strong> Cushing’sdisease. Br Med J 1977;2:215–217.130. Verhelst JA, Trainer PJ, Howlett TA, Perry L, Rees LH, GrossmanAB, et al. Short <strong>and</strong> long-term responses to metyrapone in themedical management <strong>of</strong> 91 patients with Cushing’s syndrome.Clin Endocrinol (Oxford) 1991;35:169–178.131. Thoren M, Adamson U, Sjoberg HE. Aminoglutethimide <strong>and</strong>metyrapone in the management <strong>of</strong> Cushing’s syndrome. ActaEndocrinol (Copenh) 1985;109:451–457.132. Sonino N, Boscaro M, Ambroso G, Merola G, Mantero F. Prolongedtreatment <strong>of</strong> Cushing’s disease with metyrapone <strong>and</strong>aminoglutethimide. IRCS Med Sci 1986;14:485–486.133. Miller JW, Crapo L. The medical treatment <strong>of</strong> Cushing’s syndrome.Endocr Rev 1993;14:443–458.134. Nelson AA, Woodard G. Severe adrenal cortical atrophy (cytotoxic)<strong>and</strong> hepatic damage produced in dogs by feeding 2,2-bis(parachlorophenyl)-1,1-dichloroethane (DDD or TDE). ArchPathol 1949;48:387–394.135. Southren AL, Weisenfeld S, Laufer A, Goldner MG. Effect <strong>of</strong>o,p'DDD in a patient with Cushing’s syndrome. J Clin EndocrinolMetab 1961;21:201–208.136. Sonino N. Medical treatment: Inhibitors <strong>of</strong> adrenal steroid production.J Endocrinol Invest 1992;15:234–235.137. Luton JP, Mahoudeau JA, Bouchard P, Thieblot P, HautecouvertureM, Simon D, et al. Treatment <strong>of</strong> Cushing’s disease by o,p'DDD:Survey <strong>of</strong> 62 cases. N Engl J Med 1979;300:459–464.138. Schulte HM, Benker G, Reinwein D, Sippell WG, Allolio B. Infusion<strong>of</strong> low dose etomidate: Correction <strong>of</strong> hypercortisolemia inpatients with Cushing’s syndrome <strong>and</strong> dose-response relationshipin normal subjects. J Clin Endocrinol Metab 1990;70:1426–1430.139. Wagner RL, White PF, Kan PB, Rosenthal MH, Feldman D. Inhibition<strong>of</strong> adrenal steroidogenesis by the anesthetic etomidate. NEngl J Med 1984;310:1415–1421.140. Dewis P, Anderson DC, Bu’lock DE, Earnshaw R, Kelly WF.Experience with trilostane in the treatment <strong>of</strong> Cushing’s syndrome.Clin Endocrinol (Oxford) 1983;18:533–540.141. Komanicky P, Spark RF, Melby JC. Treatment <strong>of</strong> Cushing’s syndromewith trilostane (WIN 24,540), an inhibitor <strong>of</strong> adrenal steroidbiosynthesis. J Clin Endocrinol Metab 1978;47:1042–1051.142. Nieman LK, Chrousos GP, Kellner C, Spitz IM, Nisula BC, CutlerGB, et al. Successful treatment <strong>of</strong> Cushing’s syndrome with theglucocorticoid antagonist RU 486. J Clin Endocrinol Metab1985;61:536–540.142a. Vignati F, Loli P. Additive effect <strong>of</strong> ketoconazole <strong>and</strong> octreotidein the treatment <strong>of</strong> severe adrenocorticotropin-dependenthypercortisolism. J Clin Endocrinol Metab 1999;81:2885–2890.143. Besser GM, Edwards CRW. Cushing’s syndrome. Clin EndocrinolMetab 1972;1:451–490.144. Scott HW, Liddle GW, Mulherin JL, McKenna TJ, Stroup SL,Rhamy RK. Surgical experience with Cushing’s disease. Ann Surg1977;185:524–534.145. Jenkins PJ, Trainer PJ, Plowman PN, Sh<strong>and</strong> WS, Grossman AB, WassJAH, et al. The long term outcome after adrenalectomy <strong>and</strong> prophylacticpituitary radiotherapy in adrenocorticotropin-dependentCushing’s syndrome. J Clin Endocrinol Metab 1995;80:165–171.146. McCance DR, Russell CFJ, Kennedy TL, Hadden DR, Kennedy L,Atkinson AB. Bilateral adrenalectomy: low mortality <strong>and</strong> morbidityin Cushing’s disease. Clin Endocrinol (Oxford) 1993;39:315–321.147. Welbourn RB. Survival <strong>and</strong> causes <strong>of</strong> death after adrenalectomyfor Cushing’s disease. Surgery 1985;97:16–20.148. Bax TW, Marcus DR, Galloway GQ, Swanstrom LL, SheppardBC. Laparoscopic bilateral adrenalectomy following failed hypophysectomy.Surg Endosc 1996;10:1150–1153.149. Gagner M. Laparoscopic adrenalectomy. Surg Clin North Am1996;76(3):523–537.150. O’Riordain DS, Farley DR, Young WF, Gr<strong>and</strong> CS, van HeerdanJA. Long-term outcome <strong>of</strong> bilateral adrenalectomy in patients withCushing’s syndrome. Surgery 1994;116:1088–1094.151. Schteingart DE, Conn JW, Lieberman LM, Beierwaltes WH. Persistentor recurrent Cushing’s syndrome after “total” adrenalectomy.Arch Intern Med 1972;130:384–387.152. Kelly WF, MacFarlane IA, Longson D, Davies D, Sutcliffe H.Cushing’s disease treated by total adrenalectomy: Long-termobservations <strong>of</strong> 43 patients. Q J Med 1983;52(206):224–231.153. Kemink L, Hermus A, Pieters G, Benraad T, Smals A, KloppenborgP. Residual adrenocortical function after bilateral adrenalectomyfor pituitary-dependent Cushing’s syndrome. J Clin EndocrinolMetab 1992;75:1211–1214.154. Kasperlik-Zaluska AA, Nielubowicz J, Wislawski J, Hartwig W,Zaluska J, Jeske W, et al. Nelson’s syndrome: incidence <strong>and</strong> prognosis.Clin Endocrinol (Oxford) 1983;19:693–698.155. Wislawski J, Kasperlik-Zaluska AA, Jeske W, Migdalska B, JanikJ, Zaluska J, et al. Results <strong>of</strong> neurosurgical treatment by atranssphenoidal approach in 10 patients with Nelson’s syndrome.J Neurosurg 1985;62:68–71.156. Nelson DH, Meakin JW, Dealy JB, Matson DD, Emerson K, ThornGW. ACTH-producing tumor <strong>of</strong> the pituitary gl<strong>and</strong>. New Engl JMed 1958;259:161–164.
- Page 4 and 5:
DIAGNOSIS AND MANAGEMENT OFPITUITAR
- Page 6:
To my beloved Hazel, whose love and
- Page 10:
PrefacePituitary tumors represent a
- Page 14 and 15:
ContributorsCHARLES F. ABBOUD, MD,
- Page 16 and 17:
Color PlatesColor Plates appear aft
- Page 18 and 19:
2 RANDALL, SCHEITHAUER, AND KOVACSF
- Page 20 and 21:
4 RANDALL, SCHEITHAUER, AND KOVACSr
- Page 22 and 23:
6 RANDALL, SCHEITHAUER, AND KOVACSw
- Page 24 and 25:
8 RANDALL, SCHEITHAUER, AND KOVACSt
- Page 26 and 27:
10 RANDALL, SCHEITHAUER, AND KOVACS
- Page 28 and 29:
12 RANDALL, SCHEITHAUER, AND KOVACS
- Page 30 and 31:
14 RHOTONFigure 2-1 Osseous relatio
- Page 32 and 33:
16 RHOTONFigure 2-3 Septa in the sp
- Page 34 and 35:
18 RHOTONFigure 2-5 Stepwise dissec
- Page 36 and 37:
20 RHOTONFigure 2-7 (continued on n
- Page 38 and 39:
22 RHOTONFigure 2-8 (continued on n
- Page 40 and 41:
24 RHOTONFigure 2-9 Relationships i
- Page 42 and 43:
26 RHOTONFigure 2-11 Six sagittal s
- Page 44 and 45:
28 RHOTONFigure 2-13 (continued on
- Page 46 and 47:
30 RHOTONFigure 2-15 Anterosuperior
- Page 48 and 49:
32 RHOTONFigure 2-17 (continued on
- Page 50 and 51:
34 RHOTONFigure 2-18 Right anterior
- Page 52 and 53:
36 RHOTONOPHTHALMIC ARTERY The opht
- Page 54 and 55:
38 RHOTONFigure 2-21 Anterior cereb
- Page 56 and 57:
40 RHOTONcrosses the optic chiasm t
- Page 58 and 59:
42 GOTH, MAKARA, AND GERENDAIFigure
- Page 60 and 61:
44 GOTH, MAKARA, AND GERENDAImedial
- Page 62 and 63:
46 GOTH, MAKARA, AND GERENDAIplatel
- Page 64 and 65:
48 GOTH, MAKARA, AND GERENDAIcomple
- Page 66 and 67:
50 GOTH, MAKARA, AND GERENDAImembra
- Page 68 and 69:
52 GOTH, MAKARA, AND GERENDAITable
- Page 70 and 71:
54 GOTH, MAKARA, AND GERENDAITable
- Page 73 and 74:
CHAPTER 4 / EPIDEMIOLOGY OF PITUITA
- Page 75 and 76:
Taiwan-South part, 1983-1992 23.2%
- Page 77 and 78:
CHAPTER 4 / EPIDEMIOLOGY OF PITUITA
- Page 79 and 80:
CHAPTER 4 / EPIDEMIOLOGY OF PITUITA
- Page 81 and 82:
CHAPTER 4 / EPIDEMIOLOGY OF PITUITA
- Page 83 and 84:
CHAPTER 4 / EPIDEMIOLOGY OF PITUITA
- Page 85:
CHAPTER 4 / EPIDEMIOLOGY OF PITUITA
- Page 88 and 89:
72 SHIMON AND MELMEDTable 1G Protei
- Page 90 and 91:
74 SHIMON AND MELMEDnal allelic mut
- Page 92 and 93:
76 SHIMON AND MELMEDgrowth factor s
- Page 94 and 95:
78 SHIMON AND MELMED35. Lowy DR, Wi
- Page 97 and 98:
CHAPTER 6 / TUMORIGENESIS EXPERIMEN
- Page 99 and 100:
CHAPTER 6 / TUMORIGENESIS EXPERIMEN
- Page 101 and 102:
CHAPTER 6 / TUMORIGENESIS EXPERIMEN
- Page 103 and 104:
CHAPTER 6 / TUMORIGENESIS EXPERIMEN
- Page 105 and 106:
CHAPTER 6 / TUMORIGENESIS EXPERIMEN
- Page 107 and 108:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 109 and 110:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 111 and 112:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 113 and 114:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 115 and 116:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 117 and 118:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 119 and 120:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 121 and 122:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 123 and 124:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 125 and 126:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 127 and 128:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 129 and 130:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 131 and 132:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 133 and 134:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 135 and 136:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 137 and 138:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 139 and 140:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 141 and 142:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 143 and 144:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 145 and 146:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 147 and 148:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 149 and 150:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 151 and 152:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 153 and 154:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 155 and 156:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 157 and 158:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 159 and 160:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 161 and 162:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 163 and 164:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 165 and 166:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 167 and 168:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 169 and 170:
CHAPTER 7 / PITUITARY ADENOMAS AND
- Page 171 and 172:
CHAPTER 8 / MOLECULAR PATHOLOGY 155
- Page 173 and 174:
CHAPTER 8 / MOLECULAR PATHOLOGY 157
- Page 175 and 176:
CHAPTER 8 / MOLECULAR PATHOLOGY 159
- Page 177 and 178:
CHAPTER 8 / MOLECULAR PATHOLOGY 161
- Page 179:
CHAPTER 8 / MOLECULAR PATHOLOGY 163
- Page 182 and 183:
166 VANCETable 1Lesions of the Sell
- Page 184 and 185:
168 VANCEFigure 9-1 Twenty-four-hou
- Page 186 and 187:
170 VANCEclude that every neurosurg
- Page 188 and 189:
172 VANCEgaly, prolactinoma). Pitui
- Page 190 and 191:
174 STIVER AND SHARPEFigure 10-1 Co
- Page 192 and 193:
176 STIVER AND SHARPEFigure 10-5 Cr
- Page 194 and 195:
178 STIVER AND SHARPEFigure 10-8 Fi
- Page 196 and 197:
180 STIVER AND SHARPETable 1Inciden
- Page 198 and 199:
182 STIVER AND SHARPEFigure 10-11 (
- Page 200 and 201:
184 STIVER AND SHARPEFigure 10-13 F
- Page 202 and 203:
186 STIVER AND SHARPEFigure 10-15 F
- Page 204 and 205:
188 STIVER AND SHARPEFigure 10-17 W
- Page 206 and 207:
190 STIVER AND SHARPEpituitary apop
- Page 208 and 209:
192 STIVER AND SHARPEin extrafoveal
- Page 210 and 211:
194 STIVER AND SHARPEinto the empty
- Page 212 and 213:
196 STIVER AND SHARPE5. Hoyt WF. Co
- Page 214 and 215:
198 STIVER AND SHARPE104. Wertenbak
- Page 216 and 217:
200 STIVER AND SHARPE204. Nakane T,
- Page 218 and 219:
202 EMERY AND KUCHARCZYKFigure 11-1
- Page 220 and 221:
204 EMERY AND KUCHARCZYKFigure 11-4
- Page 222 and 223:
206 EMERY AND KUCHARCZYKFigure 11-7
- Page 224 and 225:
208 EMERY AND KUCHARCZYKFigure 11-1
- Page 226 and 227:
210 EMERY AND KUCHARCZYKFigure 11-1
- Page 228 and 229:
212 EMERY AND KUCHARCZYKFigure 11-1
- Page 230 and 231:
214 EMERY AND KUCHARCZYKFigure 11-2
- Page 232 and 233:
216 EMERY AND KUCHARCZYK3. Kulkarni
- Page 235 and 236:
CHAPTER 12 / PET IN SELLAR TUMORS 2
- Page 237 and 238:
CHAPTER 12 / PET IN SELLAR TUMORS 2
- Page 239 and 240:
CHAPTER 12 / PET IN SELLAR TUMORS 2
- Page 241 and 242:
CHAPTER 13 / PITUITARY SURGERY 2251
- Page 243 and 244:
CHAPTER 13 / PITUITARY SURGERY 227F
- Page 245 and 246:
CHAPTER 13 / PITUITARY SURGERY 229F
- Page 247 and 248:
CHAPTER 13 / PITUITARY SURGERY 231F
- Page 249 and 250:
CHAPTER 13 / PITUITARY SURGERY 233F
- Page 251 and 252:
CHAPTER 13 / PITUITARY SURGERY 235T
- Page 253 and 254:
CHAPTER 13 / PITUITARY SURGERY 237h
- Page 255 and 256:
CHAPTER 13 / PITUITARY SURGERY 239t
- Page 257 and 258:
CHAPTER 13 / PITUITARY SURGERY 241T
- Page 259 and 260:
CHAPTER 13 / PITUITARY SURGERY 243T
- Page 261 and 262:
CHAPTER 13 / PITUITARY SURGERY 2451
- Page 263 and 264:
CHAPTER 14 / MEDICAL THERAPY 24714M
- Page 265 and 266:
CHAPTER 14 / MEDICAL THERAPY 249Tab
- Page 267 and 268:
CHAPTER 14 / MEDICAL THERAPY 251One
- Page 269 and 270:
CHAPTER 14 / MEDICAL THERAPY 253Fig
- Page 271 and 272:
CHAPTER 14 / MEDICAL THERAPY 255and
- Page 273 and 274:
CHAPTER 14 / MEDICAL THERAPY 257abs
- Page 275 and 276:
CHAPTER 14 / MEDICAL THERAPY 259but
- Page 277 and 278:
CHAPTER 14 / MEDICAL THERAPY 26124.
- Page 279 and 280:
CHAPTER 14 / MEDICAL THERAPY 263110
- Page 281 and 282:
CHAPTER 14 / MEDICAL THERAPY 265184
- Page 283:
CHAPTER 14 / MEDICAL THERAPY 267264
- Page 286 and 287:
270 MOOSE AND SHAWtherapy and compa
- Page 288 and 289:
272 MOOSE AND SHAWCUSHING’S SYNDR
- Page 290 and 291:
274 MOOSE AND SHAWFor patients with
- Page 292 and 293:
276 MOOSE AND SHAW19. Gomez F, Reye
- Page 295 and 296: CHAPTER 16 / PROLACTINOMAS 27916Pro
- Page 297 and 298: CHAPTER 16 / PROLACTINOMAS 281In th
- Page 299 and 300: CHAPTER 16 / PROLACTINOMAS 283resol
- Page 301 and 302: CHAPTER 16 / PROLACTINOMAS 285term
- Page 303 and 304: CHAPTER 16 / PROLACTINOMAS 287Figur
- Page 305 and 306: CHAPTER 16 / PROLACTINOMAS 289level
- Page 307 and 308: CHAPTER 16 / PROLACTINOMAS 291Optio
- Page 309 and 310: CHAPTER 16 / PROLACTINOMAS 29398. B
- Page 311 and 312: CHAPTER 17 / ACROMEGALY 29517Somato
- Page 313 and 314: CHAPTER 17 / ACROMEGALY 297Figure 1
- Page 315 and 316: CHAPTER 17 / ACROMEGALY 299pedograp
- Page 317 and 318: CHAPTER 17 / ACROMEGALY 301Table 1C
- Page 319 and 320: CHAPTER 17 / ACROMEGALY 303In histo
- Page 321 and 322: CHAPTER 17 / ACROMEGALY 305Table 2D
- Page 323 and 324: CHAPTER 17 / ACROMEGALY 307must be
- Page 325 and 326: CHAPTER 17 / ACROMEGALY 30973. Åst
- Page 327 and 328: CHAPTER 17 / ACROMEGALY 311143. Van
- Page 329 and 330: CHAPTER 17 / ACROMEGALY 313213b. Sh
- Page 331: CHAPTER 17 / ACROMEGALY 315266. Shi
- Page 334 and 335: 318 LO, TYRRELL, AND WILSONTable 1C
- Page 336 and 337: 320 LO, TYRRELL, AND WILSONFigure 1
- Page 338 and 339: 322 LO, TYRRELL, AND WILSONFigure 1
- Page 340 and 341: 324 LO, TYRRELL, AND WILSONterm cur
- Page 342 and 343: 326 LO, TYRRELL, AND WILSON(118). O
- Page 344 and 345: 328 LO, TYRRELL, AND WILSONREFERENC
- Page 348 and 349: 332 LO, TYRRELL, AND WILSON157. Nel
- Page 350 and 351: 334 BUCHFELDER AND FAHLBUSCHsized o
- Page 352 and 353: 336 BUCHFELDER AND FAHLBUSCHimmunoh
- Page 354 and 355: 338 BUCHFELDER AND FAHLBUSCHFigure
- Page 356 and 357: 340 BUCHFELDER AND FAHLBUSCHFigure
- Page 358 and 359: 342 BUCHFELDER AND FAHLBUSCH39. Gri
- Page 360 and 361: 344 YOUNGFigure 20-1 Serum prolacti
- Page 362 and 363: 346 YOUNGFigure 20-3 Images from a
- Page 364 and 365: 348 YOUNGFigure 20-5 Visual fields
- Page 366 and 367: 350 YOUNGFigure 20-7 Serial MRI fro
- Page 369 and 370: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 371 and 372: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 373 and 374: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 375 and 376: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 377 and 378: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 379 and 380: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 381 and 382: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 383: CHAPTER 21 / PEDIATRIC PITUITARY TU
- Page 386 and 387: 370 PERNICONE AND SCHEITHAUERFigure
- Page 388 and 389: 372 PERNICONE AND SCHEITHAUERFigure
- Page 390 and 391: 374 PERNICONE AND SCHEITHAUERFigure
- Page 392 and 393: 376 PERNICONE AND SCHEITHAUERFigure
- Page 394 and 395: 378 PERNICONE AND SCHEITHAUERFigure
- Page 396 and 397:
380 PERNICONE AND SCHEITHAUERFigure
- Page 398 and 399:
382 PERNICONE AND SCHEITHAUERFigure
- Page 400 and 401:
384 PERNICONE AND SCHEITHAUER32. Th
- Page 403 and 404:
CHAPTER 23 / SELLAR TUMORS 38723Sel
- Page 405 and 406:
CHAPTER 23 / SELLAR TUMORS 389mode
- Page 407 and 408:
CHAPTER 23 / SELLAR TUMORS 391Figur
- Page 409 and 410:
CHAPTER 23 / SELLAR TUMORS 393Figur
- Page 411 and 412:
CHAPTER 23 / SELLAR TUMORS 395Figur
- Page 413 and 414:
CHAPTER 23 / SELLAR TUMORS 397Figur
- Page 415 and 416:
CHAPTER 23 / SELLAR TUMORS 399most
- Page 417 and 418:
CHAPTER 23 / SELLAR TUMORS 401Figur
- Page 419 and 420:
CHAPTER 23 / SELLAR TUMORS 403Figur
- Page 421 and 422:
CHAPTER 23 / SELLAR TUMORS 405Figur
- Page 423 and 424:
CHAPTER 23 / SELLAR TUMORS 407Figur
- Page 425 and 426:
CHAPTER 23 / SELLAR TUMORS 409Figur
- Page 427 and 428:
CHAPTER 23 / SELLAR TUMORS 411Figur
- Page 429 and 430:
CHAPTER 23 / SELLAR TUMORS 413Figur
- Page 431 and 432:
CHAPTER 23 / SELLAR TUMORS 4154.4.4
- Page 433 and 434:
therapy and, in some cases, radioth
- Page 435 and 436:
CHAPTER 23 / SELLAR TUMORS 419Figur
- Page 437 and 438:
CHAPTER 23 / SELLAR TUMORS 421Figur
- Page 439 and 440:
CHAPTER 23 / SELLAR TUMORS 423Figur
- Page 441 and 442:
CHAPTER 23 / SELLAR TUMORS 425the u
- Page 443 and 444:
CHAPTER 23 / SELLAR TUMORS 427Figur
- Page 445 and 446:
CHAPTER 23 / SELLAR TUMORS 4297.2.2
- Page 447 and 448:
CHAPTER 23 / SELLAR TUMORS 431Figur
- Page 449 and 450:
CHAPTER 23 / SELLAR TUMORS 43319. P
- Page 451 and 452:
CHAPTER 23 / SELLAR TUMORS 43520. N
- Page 453 and 454:
CHAPTER 23 / SELLAR TUMORS 43716. P
- Page 455 and 456:
CHAPTER 23 / SELLAR TUMORS 4393. Wi
- Page 457 and 458:
CHAPTER 23 / SELLAR TUMORS 4414.3.
- Page 459 and 460:
CHAPTER 23 / SELLAR TUMORS 44319. T
- Page 461 and 462:
CHAPTER 23 / SELLAR TUMORS 4457. Lo
- Page 463:
CHAPTER 23 / SELLAR TUMORS 44714. M
- Page 466 and 467:
450 SAEGERTermDiffuse hyperplasiaNo
- Page 468 and 469:
452 SAEGERFigure 24-3 ACTH cell hyp
- Page 470 and 471:
454 SAEGERFigure 24-9 Septic absces
- Page 472 and 473:
456 SAEGERabnormality of the arachn
- Page 474 and 475:
458 SAEGERFigure 24-15 Densely gran
- Page 476 and 477:
460 SAEGER76. Asa SL. Tumors of the
- Page 478 and 479:
462 MILLER, ZHANG, AND KLIBANSKItio
- Page 480 and 481:
464 MILLER, ZHANG, AND KLIBANSKItum
- Page 483 and 484:
INDEXABC peroxidase method, 94Acrom
- Page 485 and 486:
INDEX 469Chordomas (cont.) Cranioph
- Page 487 and 488:
INDEX 471Glycoprotein hormones/SV4O
- Page 489 and 490:
INDEX 473Invasion (cont.)Lymphomas
- Page 491 and 492:
INDEX 475Osteogenic sarcomas, 416-4
- Page 493 and 494:
INDEX 477Pro-opiomelanocortin (POMC
- Page 495:
INDEX 479Visual outcomes (cont.) Vi