Diagnosis and Management of Pituitary Tumors

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To my beloved Hazel, whose love and encouragement sustain me; to ourlittle daughters, Molly, Olivia, and Isabelle, who give my life purpose;and to my mentors, Kalman Kovacs, Edward Laws Jr., Bernd Scheithauer,and James Rutka, who have passed on to me their passion for science anddiscovery, and upon whose shoulders I continue to stand.KAMAL THAPARTo Eva, my wife and longtime companion in the exciting journeyexploring the mysteries of pituitary tumors.KALMAN KOVACSTo Chuckie and our children, Hans and Monika—more stimulation andinspiration than I could imagine.BERND W. SCHEITHAUERSincere thanks to Debbie Lloyd and Vincent Lloyd for their continuoussupport during this project.RICARDO V. LLOYD
Page 4 and 5: DIAGNOSIS AND MANAGEMENT OFPITUITAR
Page 8: ForewordDiagnosis and Management of
Page 12: Contentsviiixxiiixv1 Pituitary Aden
Page 15 and 16: xivCONTRIBUTORSWOLFGANG SAEGER, MD,
Page 17 and 18: CHAPTER 1 / PITUITARY ADENOMAS 11Pi
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CHAPTER 3 / HYPOTHALAMIC-PITUITARY
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Table 1Pituitary Adenomas as a Prop
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Table 2Average Annual Incidence Rat
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62 YAMADATable 3Male:Female Ratio o
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Table 5Frequency of Pituitary Adeno
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66 YAMADAadenomas, suggesting that
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68 YAMADA80. Teramoto A, Tamura A,
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CHAPTER 5 / PATHOGENESIS AND MOLECU
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82 STEFANEANUFigure 6-1 Pituitary o
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84 STEFANEANUFigure 6-3 Ultrastruct
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86 STEFANEANUFigure 6-7 Pituitary t
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88 STEFANEANUirradiation, which gav
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90 STEFANEANU78. Ross DS, Kieffer J
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92 SCHEITHAUER ET AL.Figure 7-1 On
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94 SCHEITHAUER ET AL.Table 1Broad-S
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96 SCHEITHAUER ET AL.Figure 7-3RHPA
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98 SCHEITHAUER ET AL.Figure 7-5 The
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100 SCHEITHAUER ET AL.Figure 7-8 No
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102 SCHEITHAUER ET AL.Figure 7-12 C
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104 SCHEITHAUER ET AL.Figure 7-14 B
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106 SCHEITHAUER ET AL.Figure 7-18 N
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110 SCHEITHAUER ET AL.Figure 7-24 U
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112 SCHEITHAUER ET AL.Figure 7-29 T
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114 SCHEITHAUER ET AL.Figure 7-31 (
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116 SCHEITHAUER ET AL.Figure 7-32 F
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118 SCHEITHAUER ET AL.Figure 7-36 D
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120 SCHEITHAUER ET AL.Figure 7-39 L
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124 SCHEITHAUER ET AL.Figure 7-45 M
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126 SCHEITHAUER ET AL.Figure 7-48 A
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130 SCHEITHAUER ET AL.Figure 7-53 T
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132 SCHEITHAUER ET AL.Figure 7-55 B
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134 SCHEITHAUER ET AL.Figure 7-57 G
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136 SCHEITHAUER ET AL.Figure 7-59 G
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138 SCHEITHAUER ET AL.Figure 7-63 P
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140 SCHEITHAUER ET AL.Figure 7-65 S
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142 SCHEITHAUER ET AL.Figure 7-68 P
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148 SCHEITHAUER ET AL.are large and
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150 SCHEITHAUER ET AL.72. Kovacs K,
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152 SCHEITHAUER ET AL.162. Pernicon
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154 SCHEITHAUER ET AL.241. Carey RM
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156 LLOYDFigure 8-1 Schematic diagr
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158 LLOYDFigure 8-3 Schematic diagr
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160 LLOYDFigure 8-5 Comparison of i
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162 LLOYD15. Trouillas J, Sassolas
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CHAPTER 9 / DIAGNOSIS, MANAGEMENT,
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CHAPTER 10 / NEURO-OPHTHALMOLOGY 17
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CHAPTER 11 / IMAGING OF PITUITARY T
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220 MUHRFigure 12-1 PET of a patien
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222 MUHRFigure 12-6 PET-images with
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224 MUHRThere is an increased numbe
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226 THAPAR AND LAWSThe second mode
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228 THAPAR AND LAWSFigure 13-2 Pitu
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230 THAPAR AND LAWSFigure 13-4Opera
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232 THAPAR AND LAWSFigure 13-7 The
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234 THAPAR AND LAWSgenerally signif
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236 THAPAR AND LAWSIatrogenic Hypop
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238 THAPAR AND LAWSTable 3Summary o
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240 THAPAR AND LAWSa doubling in si
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242 THAPAR AND LAWSTable 6Rates Of
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244 THAPAR AND LAWSpatients. Of 177
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246 THAPAR AND LAWS63. Melmed S. Ac
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248 MOLITCHFigure 14-1Structure of
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250 MOLITCHThe reduction in tumor s
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252 MOLITCHTable 2Effect of Bromocr
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254 MOLITCHFigure 14-5Structures of
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256 MOLITCHFigure 14-6 GH concentra
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258 MOLITCHhalf-life is between 1 a
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260 MOLITCHFigure 14-8 Individual l
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262 MOLITCH65. Soto-Albors CE, Rand
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264 MOLITCH144. Nortier JWR, Crough
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266 MOLITCH224. Tyrrell JB, Brooks
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CHAPTER 15 / RADIATION THERAPY 2691
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CHAPTER 15 / RADIATION THERAPY 271e
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CHAPTER 15 / RADIATION THERAPY 273N
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CHAPTER 15 / RADIATION THERAPY 275d
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CHAPTER 15 / RADIATION THERAPY 2776
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280 ABBOUD AND EBERSOLDpresentation
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282 ABBOUD AND EBERSOLDTable 2The E
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284 ABBOUD AND EBERSOLDFigure 16-1D
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286 ABBOUD AND EBERSOLDand intrasph
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288 ABBOUD AND EBERSOLDFigure 16-3O
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290 ABBOUD AND EBERSOLDof tumor enl
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292 ABBOUD AND EBERSOLD46. Grisoli
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294 ABBOUD AND EBERSOLD143. Crosign
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296 QUABBE AND PLÖCKINGERFigure 17
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298 QUABBE AND PLÖCKINGERsecretion
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300 QUABBE AND PLÖCKINGERgaly in w
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302 QUABBE AND PLÖCKINGER(VIP) (17
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304 QUABBE AND PLÖCKINGERFigure 17
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306 QUABBE AND PLÖCKINGEReven afte
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308 QUABBE AND PLÖCKINGER33. Ho KK
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310 QUABBE AND PLÖCKINGER109. Lada
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312 QUABBE AND PLÖCKINGER182. Vale
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314 QUABBE AND PLÖCKINGER240. Chio
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CHAPTER 18 / CORTICOTROPH ADENOMAS
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CHAPTER 19 / THYROTROPH ADENOMAS 33
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CHAPTER 20 / NONFUNCTIONING PITUITA
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Table 2Treatment Optionsfor Clinica
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354 GUPTA AND RUTKAFigure 21-1 A sc
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356 GUPTA AND RUTKAdren grow. Plasm
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358 GUPTA AND RUTKAdirect subsequen
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360 GUPTA AND RUTKAtumor extension
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362 GUPTA AND RUTKAFigure 21-7 (A)
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364 GUPTA AND RUTKAan intracranial
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366 GUPTA AND RUTKA87. Danoff BF, C
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CHAPTER 22 / INVASIVE PITUITARY ADE
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388 MCKEEVER, BLAIVAS, AND GEBARSKI
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CHAPTER 24 / TUMOR-LIKE LESIONS OF
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CHAPTER 25 / FUTURE PERSPECTIVES 46
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468 INDEXAdrenocorticotrophic hormo
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470 INDEXCushing's syndrome (cont.)
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472 INDEXHutchinson, W., 2Imaging (
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474 INDEXMeningiomas (cont.)Oimmuno
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476 INDEXPituitary gland (cont.)Pre
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478 INDEXSurgery, 140, 142, 169-170
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Diagnosis and Management of Pituitary Tumors

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