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ZENTELPrescribingPRESENTATION(albendazole)InformationZentel is available in tablet and suspension formswith 400 mg or 200 mg Albendazole tablets and4% or 2% Albendazole in suspension.USESZentel is effective against the intestinal protozoalparasite Giardia lamblia (intestinalis orduodenalis).Zentel is also a broad spectrum anthelminthic forthe treatment of:Enterobius vermicularisPinworm orthreadwormTrichuris trichiura . . ... WhipwormAscaris lumbricoides . . . .Large roundwormAncylostoma duodenale . HookwormNecator americanus.. HookwormStrongyloides stercoralisHymenolepis nanaTaenia spp .. ..... Tapewormin single or mixed manifestationsabove.of any of theAlbendazole may also be used for systemichelminth infections: the appropriate data sheetshould be consulted when treating hydatiddisease, cysticercosis and other systemicinfections.DOSAGE AND ADMINISTRATIONUnder medical prescriptionIn cases of giardiasis: Zentel 400 mg as asingle daily dose should be given for 5 days.In cases of Enterobius vermicularis, Trichuristrichiura, Ascaris lumbricoides, Ancylostomaduodenale and Necator americanus the usualdose in both adults and children over 2 years ofage is: 400mg (two 200 mg Zentel tablets or 10or 20 ml (400 mg) of Zentel suspension) as asingle dose.Usual dose in children 1-2 years of age: 200 mg(one 200 mg Zentel tablet or 5 or 10 ml of Zentelsuspension) as a single dose.In cases of suspected or confirmedStrongyloidiasis, Taeniasis or Hymenolepis nanainfestation, Zentel 400 mg once daily should begiven for 3 consecutive days. In cases of provenHymenolepis nana infestation, retreatment in10-21 days is recommended.If the patient is not cured on follow-up after 3weeks, a second course of treatment isindicated.The tablets may be chewed, swallowed orcrushed and they should be taken with food.No specific procedures, such as fasting orpurging, are required.CONTRA-INDICATIONS, WARNINGS, ETCCautionsUse in pregnancy: Because albendazole wasfound to be embryotoxic and teratogenic in therat and rabbit, its use is contra-indicated inpregnant women or those likely to be pregnant.For women of childbearing age (15-40 years),Zentel should be administered within 7 daysafter the start of normal menstruation, or after anegative pregnancy test.Use during lactation: It is not known whetheralbendazole or its metabolites are secreted inhuman breast milk. Zentel should not, therefore,be used during lactation unless the potentialbenefits are considered to outweigh the potentialrisks associated with treatment.Adverse reactions: A few cases of uppergastrointestinal symptoms and diarrhoea,headache and dizziness have been reported, butno definite relationship with the drug has beenshown.FURTHERINFORMATIONIn addition to its vermicidal properties,albendazole has been found to have bothovicidal and larvicidal properties in man.Pharmaceutical precautionsSuspensions should be protected from directsunlight. They should also be shaken well beforeuse.Zentel is a trademark.thK ITELlE'ltttmooml