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<strong>126</strong><br />

CHAPTER<br />

Dental Procedures:<br />

Anesthetic Considerations<br />

Steven Ganzberg and Brian Chanpong<br />

THE EVOLUTION OF ANESTHESIA<br />

PRACTICE IN DENTISTRY<br />

In the mid-19th century, urban dentists regularly met patients who<br />

refused restorative treatment for fear of the pain inflicted. A few<br />

dentists searched for new techniques of effective pain control. Horace<br />

Wells, (a dentist) of Hartford, Connecticut recognized what others<br />

had ignored, the analgesic potential of nitrous oxide. A second New<br />

Englander, William Thomas Green Morton, briefly shared a dental<br />

practice with Horace Wells. Morton gained an invitation to give a<br />

public demonstration (of ether anesthesia) in the Bullfinch amphitheater<br />

of the Massachusetts General Hospital. At the moment that<br />

the procedure was completed, John Colton Warren turned to his<br />

audience and announced “Gentleman, this is no humbug.”<br />

Toski JA, Bacon DR, Calverley RK. The history of<br />

anesthesiology. In: Barash PG, Cullen BF, Stoelting RK,<br />

editors. Clinical Anesthesia. 4th ed. Philadelphia:<br />

Lippincott Williams and Wilkins; 2001.<br />

History has recorded that members of the dental profession have<br />

consistently been in the forefront in the research and development<br />

of new techniques and medications for the management<br />

of pain and anxiety. 1 In 1844, Horace Wells, a dentist, first<br />

attempted to demonstrate the effects of nitrous oxide but unfortunately<br />

had less than ideal results. His former dental partner,<br />

William T.G. Morton, experimented with ether and gave the first<br />

successful public demonstration of the powers of that drug at what<br />

would be named the Ether Dome in Massachusetts General<br />

Hospital in 1846. By practicing this art form in their offices, they<br />

unknowingly pioneered the first ambulatory office-based anesthetics.<br />

It became common for dentists to provide 100% nitrous<br />

oxide via face mask, relying on patient skin color to determine<br />

adequate anesthesia, and then stimulating the patient with a dental<br />

extraction to increase ventilation and emergence from anesthesia.<br />

Ever since, anesthesia has been a vital component of dentistry. 2<br />

Harvard Dental School’s first Dean, Nathan Cooley Keep, has<br />

been credited with providing the first obstetrical anesthetic in the<br />

United States. In the 1930s, Leonard Monheim, a dentist who<br />

studied anesthesia under Frances Foldes, went on to become the<br />

only trained anesthesiologist at the Presbyterian Hospital in<br />

Pittsburgh for a considerable period of time. In 1949, he established<br />

the first department of anesthesiology in a dental school at<br />

the University of Pittsburgh. 3<br />

Dental and minor oral surgery is particularly amenable to<br />

regional anesthesia. In 1884, Halsted and Hall successfully used<br />

4% cocaine hydrochloride to block the inferior alveolar nerve,<br />

giving rise to dental regional anesthesia, albeit with significant<br />

cardiac adverse effects. 4 Procaine, developed in 1904, was<br />

employed for many years by dentists, minimizing the use of<br />

inhalation techniques, except for extractions. Lidocaine, developed<br />

in 1943, especially with the addition of epinephrine, provided<br />

more adequate duration and depth of local anesthesia with<br />

fewer allergic reactions and further allowed dentists to rely less on<br />

general anesthesia. Today, many dental procedures can be accomplished<br />

under local anesthesia alone or with the addition of<br />

minimal to moderate sedation, most commonly with nitrous<br />

oxide–oxygen, in the dental office.<br />

Dentists are quite adept at the administration of local anesthesia<br />

and may provide many procedures in the office setting that<br />

medical specialists, such as otolaryngologists, would only provide<br />

in the operating room under general anesthesia, such as lingual<br />

frenectomy or biopsy. For maxillary dental/oral surgery, infiltration<br />

anesthesia is most commonly used. Nerve block of the infraorbital<br />

nerve for the maxillary incisors or posterior superior<br />

alveolar nerve for the maxillary molars can also be employed.<br />

Palatal gingival anesthesia via infiltration is needed for oral<br />

surgery of the maxillary teeth. Full second division block via an<br />

intraoral approach through the greater palatine foramen or via an<br />

extraoral approach through the mandibular notch is generally not<br />

necessary. For mandibular dental or oral surgery, inferior alveolar<br />

and lingual nerve block provided as one injection is usually<br />

provided. For oral surgery of the molar and premolar teeth, long<br />

buccal nerve block is needed to provide adequate anesthesia of the<br />

buccal gingival. Full third division block via an extraoral approach<br />

through the mandibular notch is rarely necessary.<br />

In addition to developments in anesthesia for dentistry,<br />

dentistry has expanded its scope of practice to include a wide array<br />

of surgical procedures involving the mouth and jaws. Dental<br />

specialists in pediatric dentistry provide the vast majority of<br />

routine pediatric dental care in the operating room, such as<br />

fillings, pulp treatments (root canal therapy for primary teeth),<br />

crowns, simple extractions, minor excisional biopsy, and<br />

frenectomy. Oral and maxillofacial surgeons typically manage<br />

more complicated oral surgery such as exposure or removal of<br />

impacted teeth, dental implant placement to replace missing teeth,<br />

removal of jaw tumors, and management of complex orofacial<br />

infections, particularly those that involve airway compromise or<br />

require formal excision and drainage with drain placement.<br />

Additionally, orthoganthic surgery (LeFort osteotomy, sagittal<br />

split, and other mandibular osteotomies), open and closed<br />

reduction with or without internal fixation of jaw and facial


CHAPTER <strong>126</strong> ■ Dental Procedures: Anesthetic Considerations 2081<br />

fractures, and distraction osteogenesis of the jaw are commonly<br />

performed by oral and maxillofacial surgeons. Lastly, cleft palate<br />

repair, craniofacial anomaly reconstruction, facial plastic surgery,<br />

tracheotomy, temporomandibular joint (TMJ) surgery (at times<br />

with costochondral bone graft), jaw reconstructive surgery, usually<br />

in conjunction with cleft palate deformities or trauma and with<br />

iliac crest bone graft, are provided. Many of these latter procedures<br />

require overnight admission.<br />

In many situations, therefore, regional anesthesia is either<br />

ineffective or not possible. Oral sedation, intravenous sedation<br />

and general anesthesia are all used by dentists in a variety of<br />

settings to complete surgical goals.<br />

TRAINING OF DENTISTS IN SEDATION<br />

AND GENERAL ANESTHESIA<br />

Many dentists, through additional postgraduate residencies, are<br />

trained to provide sedation as well as general anesthesia. To ensure<br />

adequate training and competence, a dentist must legally posses a<br />

special permit from the state/provincial dental board to provide<br />

intravenous sedation or deep sedation/general anesthesia. Many<br />

states now require a special permit for pediatric or adult oral<br />

moderate sedation as well. No permit is generally required for<br />

minimal sedation or nitrous oxide–oxygen sedation. The postgraduate<br />

residencies that require extensive sedation or general<br />

anesthesia experience include pediatric dentistry, oral and maxillofacial<br />

surgery, and dental anesthesiology. Oral surgeons have<br />

consistently been in the forefront of office-based deep sedation/<br />

general anesthesia. However, with the elimination of operator–<br />

anesthetist deep sedation and general anesthesia in medicine, as<br />

well as the limitation of the oral surgeon to providing only<br />

extractions for dental concerns, specific residencies in anesthesiology<br />

for dentists were developed. The training and scope of<br />

practice of dentists involved in pediatric sedation and general<br />

anesthesia are described below.<br />

Pediatric Dentists<br />

U.S. training programs require a minimum of 20 cases of dental<br />

treatment under general anesthesia in the operating room and an<br />

additional one month rotation on the anesthesiology service itself<br />

to familiarize residents with the provision of general anesthesia<br />

and airway management. 5 Pediatric dentists are trained in oral<br />

moderate sedation and/or nitrous oxide–oxygen sedation for<br />

children that might have limited dental treatment needs and have<br />

some capability to cooperate but are anxious for care in the dental<br />

office. The most common oral sedation medications include<br />

midazolam or chloral hydrate with hydroxyzine but many<br />

different medications and combinations are used. There is an<br />

increasing use of general anesthesia for precooperative or uncooperative<br />

children, especially those with more than one, or<br />

possibly two, required short dental treatments. 6 Additionally,<br />

pediatric dentists are frequently called upon to treat adult mentally<br />

or physically challenged patients in the operating room.<br />

Oral and Maxillofacial Surgeons<br />

In the United States and Canada, oral surgeons must complete a<br />

4-month rotation on the anesthesia service and provide 90 deep<br />

sedations and 10 general anesthetics for clinic oral surgery patients<br />

as part of their program’s requirements. There is no specific<br />

requirement for anesthetizing children, defined as less than<br />

13 years old, except that the resident must be trained in the unique<br />

anatomic/pharmacologic/physiologic variations of the pediatric<br />

anesthesia patient. 7 Many U.S. and Canadian oral surgeons provide<br />

deep sedation for older teenaged pediatric patients with a limited<br />

number intravenously sedating preadolescent children in the<br />

dental office and rarely children younger than 6 years old. In this<br />

last remaining operator–anesthetist model, the oral surgeon<br />

provides both the deep sedation and the surgery in conjunction<br />

with a surgical dental assistant and another dental assistant to<br />

monitor the patient and provide airway support. In the United<br />

Kingdom, single drug intravenous moderate sedation is the only<br />

I.V. sedation regimen administered by dentists and may not be<br />

practical, especially for many younger pediatric patients. 8<br />

Dentist Anesthesiologists<br />

Dentist anesthesiologists are dentists in the United States and<br />

Canada who have completed 2 to 3 years of accredited training in<br />

anesthesiology, with a minimum of 1 year of operating room<br />

general anesthesia for all types of surgical procedures and additional<br />

specialized rotations in office-based anesthesia for dental,<br />

oral, and maxillofacial surgery. They provide the full range of<br />

anesthesia services for patients of all ages and medical complexity,<br />

from moderate sedation to intubated general anesthesia, for<br />

dental, oral, and maxillofacial procedures in hospitals, ambulatory<br />

surgery centers, and office settings. 9 Dentist anesthesiologists in<br />

the United States almost exclusively provide anesthesia services<br />

only. Most administer anesthesia in dental offices where they<br />

generally provide all required monitors, anesthetic drugs, and<br />

emergency drugs/equipment for the provision of safe anesthesia<br />

care while the dentist or oral surgeon operates. With the advent of<br />

newer, shorter-acting anesthetic agents and improved monitoring<br />

techniques, there is an increasing use of the office-based setting<br />

for general anesthesia for all types of procedures, medical or<br />

dental, particularly in North America. 10<br />

PREANESTHETIC ASSESSMENT<br />

Dental and oral surgery is frequently needed over a patient’s<br />

lifetime. This has particular implications for the mentally and<br />

physically challenged patient who may require general anesthesia<br />

every 1 to 3 years for routine dental care. Furthermore, as dental<br />

and minor oral surgery carries very low surgical risk, the administration<br />

of anesthesia may potentially be the most hazardous<br />

component of the perioperative experience. Therefore, the preanesthetic<br />

evaluation takes on increased importance.<br />

The vast majority of dental or oral surgical procedures are<br />

performed on an ambulatory, outpatient basis. The abbreviated<br />

time to complete the admission process poses issues common to<br />

all same-day surgical care, such as ensuring that patients receive<br />

complete preoperative medical evaluation and continue appropriate<br />

medications on the day of surgery. This is further complicated<br />

by the fact that pediatric dentists can not complete their own<br />

history and physical within 7 days of surgery, a Joint Commission<br />

requirement in the United States. This means that the history and<br />

physical must be performed by the patient’s pediatrician a few days<br />

before the procedure and forwarded to the anesthesia department<br />

for review. When this information is not available, the case must


2082 PART 5 ■ Anesthetic, Surgical, and Interventional Procedures: Considerations<br />

be cancelled. Good communication with the pediatric dentist is<br />

essential if optimal care is to be provided. In the United States and<br />

Canada, oral and maxillofacial surgeons may have only a dental<br />

(DDS, DMD) degree or are dually qualified with a medical degree<br />

(MD) and license. In the United Kingdom, most oral and<br />

maxillofacial surgeons are dually qualified. Regardless of degree,<br />

in most U.S. hospitals, oral surgeons can independently admit<br />

patients and provide admission history and physical examination,<br />

whereas pediatric dentists are not so trained.<br />

As nasotracheal intubation is likely planned, all patients should<br />

receive a careful airway examination with additional evaluation of<br />

the nares. If it is possible to determine the most patent nares<br />

preoperatively, this is ideal. A history of epistaxis and from which<br />

nares should be elicited and may lead to a decision to avoid nasal<br />

intubation. Chronic allergic rhinitis may predispose to nasal<br />

bleeding during intubation and on extubation. A history of snoring<br />

or frank obstructive sleep apnea should provoke additional caution<br />

especially with the possibly increased difficulty with nasal<br />

intubation. As with all pediatric patients, it is important to remember<br />

that the pediatric patient will be exfoliating their primary<br />

teeth from the age of 6–7 years until the age of 11–12 years. It is<br />

important to determine if there are currently any loose teeth in the<br />

patient’s mouth that may accidentally become avulsed during<br />

intubation.<br />

Since many pediatric patients receiving dental care under<br />

general anesthesia are precooperative (


CHAPTER <strong>126</strong> ■ Dental Procedures: Anesthetic Considerations 2083<br />

are sensorally challenged as well and find the feeling of local<br />

anesthesia of the oral cavity difficult to tolerate. The planned use<br />

of an intravenous nonsteroidal anti-inflammatory drug (NSAID)<br />

such as ketorolac or an opioid may be preferred over local anesthesia.<br />

Similarly, when planning for anesthetic maintenance and<br />

emergence, it may be preferable to consider a total intravenous<br />

propofol-based technique. or early discontinuation of inhalation<br />

agents near case completion with subsequent propofol infusion,<br />

to allow rapid and clear recovery. Planned extubation in the<br />

operating room may be preferable due to potential combativeness.<br />

Facial Cellulitis Patient<br />

The spread of dental infection to the fascial spaces of the face<br />

results in facial swelling that may or may not compromise the<br />

airway. Advanced Ludwig angina, with floor of mouth elevation,<br />

difficulty managing oral secretions, and body posturing to maintain<br />

airway patency, is rare in younger children, as this usually<br />

occurs with abscess spread from the second and third molars,<br />

which erupt after 12 years of age. When present, awake fiberoptic<br />

intubation is essential, because airway anatomy is frequently<br />

distorted, making direct laryngoscopy very difficult or impossible;<br />

loss of airway with sedation or general anesthesia is common, and<br />

there is concern of purulent discharge and risk of aspiration with<br />

airway instrumentation. More commonly in the pediatric patient,<br />

there is a buccal space swelling with or without trismus. Mouth<br />

opening may be severely limited but is usually due to muscle<br />

splinting secondary to pain, which resolves with unconsciousness<br />

and analgesia. Preoxygenation with slow inhalation induction to<br />

maintain spontaneous respiration or slow intravenous induction<br />

with assessment of mask ventilation can be planned, because<br />

usually, with increasing depth of inhalation anesthesia or paralysis,<br />

mouth opening can be accomplished to acceptable levels for<br />

endotracheal intubation. Appropriately sized oral and nasopharyngeal<br />

airways should be readily available. At times, a ratchet<br />

style mouth prop, used by the dentist to keep the mouth open<br />

under anesthesia, may be needed to increase mouth opening.<br />

Once the airway is secured, conventional anesthetic management<br />

is usually planned. If airway compromise was present at induction<br />

and fiberoptic intubation needed, transfer to the intensive care<br />

unit for continued post-operative intubation is generally necessary.<br />

Facial Trauma/TMJ Patient<br />

The patient with facial trauma presents several concerns for the<br />

anesthesiologist. Jaw fractures usually limit mouth opening due<br />

to muscle splinting secondary to pain. This presents a similar<br />

situation as with facial cellulitis, where a surgical depth of<br />

anesthesia usually allows mouth opening to be accomplished.<br />

However, depending on the type of fracture, forced mouth<br />

opening may worsen fracture separation. Preoperative consultation<br />

with the oral surgeon is important. If maxillomandibular<br />

fixation (wiring of the jaws together) is planned, nasotracheal<br />

intubation will be required. If intraoral bleeding has occurred, the<br />

patient should be considered to have a full stomach and appropriate<br />

precautions taken. There is the additional concern of TMJ<br />

trauma, even if no fracture is evident. If TMJ disc displacement<br />

has occurred, this may not allow full mouth opening despite a<br />

deep anesthetic plane. If mouth opening is limited, this should be<br />

discussed with the oral surgeon preoperatively to determine<br />

etiology and possible complications at anesthetic induction.<br />

Alternative intubation techniques may need to be considered. TMJ<br />

surgery itself is very rare for a patient younger than 18 years of<br />

age. Juvenile rheumatoid arthritis can affect the TMJ and, of<br />

course, jaw opening would need careful evaluation, as would<br />

cervical range of motion. Patients with skull base fracture should<br />

not receive nasal intubation. 19<br />

Post–Head and Neck Radiation<br />

The pediatric patient may have received radiation therapy to the<br />

head and neck for various cancers, typically for nasopharyngeal<br />

carcinoma. Fibrosis of the masticatory muscles is expected and<br />

mouth opening is usually quite limited. Dental care is almost<br />

always provided under general anesthesia due to severely<br />

restricted mouth opening. Depending on the degree of limited<br />

mouth opening, a variety of techniques can be considered based<br />

on patient age, including fiberoptic intubation, Bullard laryngoscope<br />

or blind nasal intubation. Extractions are commonly avoided<br />

in this population due to the risk of osteoradionecrosis, a form of<br />

severe osteomyelitis secondary to poor bone blood supply. Hyperbaric<br />

oxygen therapy before and after oral surgery is necessary to<br />

minimize this risk.<br />

ANTIBIOTIC PROPHYLAXIS<br />

Dental and oral surgery is conducted in an environment that is<br />

inherently inundated with bacteria. The need for antibiotics for<br />

these procedures is, however, quite limited. Surgical antibiotic<br />

prophylaxis is generally not provided for routine dental or minor<br />

oral surgical care. However, in the patient immunocompromised<br />

for whatever reason, including the cancer chemotherapy patient,<br />

surgical antibiotic prophylaxis is generally provided, using the<br />

same regimen as for infective endocarditis (IE) prophylaxis (Table<br />

<strong>126</strong>–1). With a functional neutrophil count of at least 1500 cells/<br />

mm 3 , antibiotic prophylaxis may not be necessary to help combat<br />

bacterial infection. Physician consultation is recommended.<br />

Infective endocarditis prophylaxis for dental procedures has<br />

been updated to reflect the fact that transient bacteremias likely<br />

occur more frequently with daily activities, such as tooth brushing<br />

and chewing, than with dental procedures themselves. Addition -<br />

ally, a risk stratification for those cardiac conditions with the<br />

highest morbidity and mortality from endocarditis were identified.<br />

A limited number of patients are now being recommended for IE<br />

antibiotic prophylaxis. Tables <strong>126</strong>–1 and <strong>126</strong>–2 describe the<br />

cardiac conditions for which IE antibiotic prophylaxis is now<br />

recommended and currently accepted regimens. 13 Any patient<br />

taken to the operating room for a dental procedure will experience<br />

a bacteremia and nasal intubation itself may also provoke<br />

bacteremia. What may not be well addressed in the newest guide -<br />

lines is the effect of duration of bacteremia as most office dental<br />

procedures, especially on children, are short resulting in a short<br />

duration bacteremia. When full mouth rehabilitation is provided<br />

in the operating room, high levels of bacteremia may be present<br />

for hours. Consultation between the cardiologist, anesthesiologist<br />

and dentist may lead to a decision to proceed with antibiotic<br />

prophylaxis until enough time has passed to assess the efficacy of<br />

the new prevention guidelines. This decision should be weighed<br />

against the risk of anaphylaxis from antibiotic administration as<br />

well as future increased antibiotic resistance.


2084 PART 5 ■ Anesthetic, Surgical, and Interventional Procedures: Considerations<br />

TABLE <strong>126</strong>-1. Indications for Preventive Antibiotics<br />

Prior to a Dental Procedure<br />

1. Artificial heart valves<br />

2. A history of infective endocarditis<br />

3. Certain specific, serious congenital (present from birth) heart<br />

conditions, including<br />

Paired or incompletely repaired cyanotic congenital heart<br />

disease, including palliative shunts and conduits<br />

A completely repaired congenital heart defect with prosthetic<br />

material or device, whether placed by surgery or by<br />

catheter intervention, during the first 6 months after the<br />

procedure<br />

Any repaired congenital heart defect with residual defect<br />

at the site or adjacent to the site of a prosthetic patch or<br />

a prosthetic device<br />

4. A cardiac transplant that develops a problem in a heart valve<br />

The decision to provide antibiotic prophylaxis for nonvalvular<br />

cardiac devices, ventriculoperitoneal and ventriculoatrial shunts,<br />

arteriovenous shunts, and central lines is controversial. Recommendations<br />

that suggest no prophylaxis for some of these devices<br />

in most circumstances have been made based on currently<br />

available evidence. 14 However, many physicians and surgeons still<br />

request antibiotic prophylaxis in these situations. Again, consultation<br />

between the physician, anesthesiologist and dentist may lead<br />

to a decision to proceed with antibiotic prophylaxis. This decision<br />

should also be weighed against the risk of anaphylaxis from<br />

antibiotic administration as well as future increased antibiotic<br />

resistance. The standard IE antibiotic prophylaxis regimen is<br />

commonly used.<br />

Although total joint replacement (TJR) is rare in the pediatric<br />

population, it should be remembered that the American Association<br />

of Orthopedic Surgeons and the American Dental Association<br />

have joint recommendations for antibiotic prophylaxis to<br />

prevent TJR infection following invasive dental procedures for<br />

2 years postinsertion, as well as at all times for any immunocompromised<br />

patient and for the hemophiliac. 15<br />

Except for these very specific situations, antibiotics are<br />

generally not administered for routine dental or oral surgical<br />

procedures.<br />

INTRAOPERATIVE CONSIDERATIONS<br />

Surgical Access<br />

The challenge of having to share the airway with the dentist or oral<br />

surgeon presents a challenge to the anesthesiologist. Although a<br />

nonintubated general anesthetic is possible with a dental patient,<br />

placing either an endotracheal tube (ETT) or a LMA to secure the<br />

airway may provide a higher level of comfort for the anesthesiologist.<br />

Either nasal or oral intubation can be considered, although<br />

dentists greatly prefer the nasal endotracheal approach. Using a<br />

flexible LMA or an oral ETT will interfere with the dentist taking<br />

mandibular dental radiographs or checking the occlusion (bite).<br />

A dentist must manually manipulate the mandible in order to<br />

evaluate the proper closure of the mouth, which cannot be done<br />

with the presence of an oral tube or LMA. For radiographs, the<br />

tube may need to be moved from side to side. Jaw fracture repair<br />

requiring maxillomandibular fixation or orthognathic surgery will<br />

exclude the use of a flexible LMA or an oral ETT and necessitates<br />

the use of a nasal intubation.<br />

Nasal Intubation Techniques<br />

A preformed nasal ETT is by far the most common form of airway<br />

management for dental or oral surgery. This allows clear access to<br />

the oral cavity for the dentist and allows for greatly increased ETT<br />

stability, minimizing the possibility of unplanned extubation<br />

during the procedure. Standard formulas can be used to determine<br />

ETT size, but for patients with low growth for age, an ETT 0.5 mm<br />

or more smaller than calculated may be needed to allow for<br />

atraumatic passage through the nasal structures. The relatively<br />

large leak with use of a smaller noncuffed ETT is offset by the use<br />

of a throat pack by the dentist which allows for good positive<br />

pressure ventilation intraoperatively. Postoperative nasal bleeding<br />

is the most common serious complication of nasal intubation,<br />

reported in 20 to 35% of cases. If it is possible to determine the<br />

most patent nares, this side is usually attempted first. If obstruction<br />

is encountered, the opposite nares should be tried. Adenoidectomy<br />

20 and turbinectomy 21 have been reported following<br />

nasotracheal intubation. Nasal tissue can also become dislodged<br />

during nasotracheal intubation and be inadvertently carried into<br />

the trachea by the tube. 22 Exfoliating teeth from ages 6 to 12 may<br />

TABLE <strong>126</strong>-2. Antibiotic Regimens<br />

Single Dose 30 to 60 min Before Procedure<br />

Situation Agent Adults Children<br />

Able to take oral medication Amoxicillin 2 g 50 mg/kg<br />

Unable to take oral medication Ampicillin 2 g I.M. or I.V. 50 mg/kg I.M. or I.V.<br />

Cefazolin or ceftriaxone 1 g I.M. or I.V. 50 mg/kg I.M. or I.V.<br />

Allergic to penicillins or ampicillin Cephalexin* † 2 g 50 mg/kg<br />

Clindamycin 600 mg 20 mg/kg<br />

Azithromycin or clarithromycin 500 mg 15 mg/kg<br />

Allergic to penicillins or ampicillin Cefazolin or ceftriaxone † 1 g I.M. or I.V. 50 mg/kg I.M. or I.V.<br />

and unable to take oral medication Clindamycin 600 mg I.M. or I.V. 20 mg/kg I.M. or I.V.<br />

I.M. = intramuscular; I.V. = intravenous.<br />

*Or other first- or second-generation oral cephalosporin in equivalent adult or pediatric dosage.<br />

Cephalosporins should not be used in an individual with a history of anaphylaxis, angioedema, or urticaria with penicillins or ampicillin.


CHAPTER <strong>126</strong> ■ Dental Procedures: Anesthetic Considerations 2085<br />

Figure <strong>126</strong>-1. Red rubber catheter placed over the distal end of<br />

the preformed nasotracheal tube.<br />

A<br />

become dislodged during laryngoscopy and potentially be<br />

aspirated. Methods of relatively atraumatic intubation can reduce<br />

these complications of nasal intubation. One of the more common<br />

difficulties encountered is once the ETT has passed the<br />

vocal cords, there is obstruction at the level of the cricoid cartilage.<br />

This is easily overcome by turning the tube at the nose to redirect<br />

the distal end. A variety of other techniques have been<br />

proposed to aide in atraumatic intubation. The following are some<br />

methods that have been suggested: Various tube guides, precurving<br />

the ETT, thermosoftening the ETT, and topical nasal<br />

vasoconstrictors.<br />

The use of a red rubber catheter as a guide for the nasotracheal<br />

tube was shown to reduce the severity of bleeding. 23 The flared<br />

end of the #10–12 French red rubber catheter is placed over the tip<br />

of the tube (Figure <strong>126</strong>–1). After lubricating the catheter with<br />

water-soluble lubricant, the distal end of the catheter is placed into<br />

the patient’s nasal cavity. The tip of the catheter is then retrieved<br />

from the oral cavity with a Magill forceps and disconnected from<br />

the nasotracheal tube, which is then advanced into the trachea. 24<br />

For nasal passages through which it is difficult to pass the<br />

nasotracheal tube, a suction catheter can be used as a guide. The<br />

suction catheter is placed inside the tube prior to insertion into<br />

the chosen nares (Figure <strong>126</strong>–2). The catheter will help navigate<br />

Figure <strong>126</strong>-2. Suction catheter placed inside a 5.0 nasal RAE tube.<br />

B<br />

Figure <strong>126</strong>-3. Stylet placed in the distal end of the preformed<br />

nasotracheal tube to form a pigtail.<br />

through the nasal passage first and then the nasotracheal tube can<br />

follow over it similar to the Seldinger technique<br />

Precurving the nasal tube can also aid the intubation process.<br />

A stylet can be inserted into the end of a nasotracheal tube which<br />

can then be bent to resemble a pigtail 5 to 10 minutes before the<br />

beginning of the case (Figures <strong>126</strong>–3, <strong>126</strong>–4, and <strong>126</strong>–5). Just<br />

before using the tube, the stylet is withdrawn from the tube. As a<br />

result the tube will have a slight curve to it. This will help facilitate<br />

the passage of the tube as it is less likely to be caught up in the<br />

bulge of the posterior nasopharynx at the level of C2. Additionally,<br />

with the tip of the tube pointing ventrally, guiding the tube into the<br />

trachea may be accomplished without need for a Magill forceps,<br />

although one should always be available.<br />

One of the most common methods to allow atraumatic<br />

nasotracheal intubation is thermosoftening of the tube. When the<br />

distal 2 to 3 centimeters of the tube is placed in sterile water, heated<br />

to at least 450°C for several seconds immediately before insertion,<br />

ETT passage through the nasal cavity is similar to a soft nasophyarngeal<br />

tube, thus reducing the incidence of epistaxis. 25 It<br />

should be noted that heating of too much length of the ETT can<br />

make it difficult to “turn the tube” to allow passage past the cricoid<br />

cartilage, as the ETT may be so soft that it twists on itself.


2086 PART 5 ■ Anesthetic, Surgical, and Interventional Procedures: Considerations<br />

managed with an oral ETT or an LMA in order to avoid a nasal<br />

bleeding or other trauma or in the case of the patient with bilateral<br />

choanal atresia where there may not be enough space the nasal<br />

passages to pass an ETT.<br />

Figure <strong>126</strong>-4. Different view of the nasotracheal tube with the<br />

stylet placed to form a pig tail.<br />

Vasoconstrictors are often used, at times in conjunction with<br />

one of the other previously mentioned techniques. Oxymetazoline<br />

0.05% is probably most commonly used and has been shown to<br />

be as effective as 10% cocaine in reducing the incidence of<br />

bleeding during intubation. 26<br />

As an alternative to direct laryngoscopy, the use of a trachlight<br />

has been suggested. 27 Hung and Stewart suggested the use of a<br />

modified trachlight for nasotracheal intubation. With the rigid<br />

stylet removed, the trachlight is inserted into the nasotracheal<br />

tube. After placement into either nares, the combination tube and<br />

trachlight is advanced until a loss of resistance is felt. Once the<br />

operating room lights are dimmed, the light source is turned on to<br />

visualize the location of the tip. A jaw lift is required in order to<br />

raise the epiglottis. Once the light source is at its brightest and in<br />

the midline, the tube is slowly advanced. Once it enters the glottis<br />

the light should remain bright and should be seen just below the<br />

thyroid prominence. 27 The trachlight can then be removed and<br />

the placement of the tube verified.<br />

There are a number of conditions mentioned under “Preanesthetic<br />

Assessment” that describe relative contraindications to<br />

nasotracheal intubation. These include history of palatopharyngoplasty,<br />

frequent epistaxis, bilateral choanal atresia, coagulopathy,<br />

or a suspected basal skull fracture. These patients may best be<br />

Laryngeal Mask Airway and<br />

Oral Endotracheal Tube<br />

Since its approval by the Food and Drug Administration in 1991,<br />

LMAs have been used for dental restoration procedures 16 and for<br />

oral and maxillofacial surgical procedures 17 with great success. The<br />

original LMA tubing is stiff and has a large diameter; however, the<br />

development of the wire-reinforced LMA provides a flexible and<br />

smaller tubing that can be taped to either side of the oral cavity or<br />

down the midline of the chin. As can be seen in Figures <strong>126</strong>–6 and<br />

<strong>126</strong>–7, the maxillary arch and sometimes the mandibular arch can<br />

be fully isolated with a rubber dam without interfering with the<br />

LMA tubing. A throat pack will still need to be placed by the<br />

dentist or anesthesiologist.<br />

An oral endotracheal tube can also be used. A standard, preformed<br />

RAE or coiled ETT can be used. Securing the ETT is<br />

particularly important. If the mandibular anterior teeth are not to<br />

be restored, the tube can be secured in the midline, as for<br />

tonsillectomy, although a mouth gag is not used. Alternatively, the<br />

tube may pass posterior to the back teeth and taped to the side of<br />

the face. This will likely require moving the tube to the opposite<br />

side as needed. Placement of the laryngoscope allows the distal<br />

end of the tube to be securely moved in its entirely, rather than<br />

only the upper portion, which may predispose to extubation.<br />

Throat Pack<br />

When a dentist is working in the mouth, regardless of whether it<br />

is restorative dentistry or surgical extractions, a gauze throat pack<br />

Figure <strong>126</strong>-5. Shape of the nasotracheal tube with the stylet removed<br />

before intubation.<br />

Figure <strong>126</strong>-6. Flexible laryngeal mask airway with rubber dam<br />

placed for the maxillary arch.


CHAPTER <strong>126</strong> ■ Dental Procedures: Anesthetic Considerations 2087<br />

Figure <strong>126</strong>-8. Throat pack with a radio-opaque lining.<br />

Figure <strong>126</strong>-7. Flexible laryngeal mask airway with rubber dam<br />

placed for the mandibular arch.<br />

is generally placed in the throat or hypopharynx behind the<br />

tonsillar fauces to prevent any debris from migrating to the hypopharynx.<br />

Any debris left behind can potentially be aspirated by<br />

the patient upon extubation. However, complications have arisen<br />

when the throat pack was accidentally left behind, which has led<br />

to airway obstruction or ingestion 28 and has even resulted in<br />

death. 29 The anesthesiologist must also be cognizant of the throat<br />

pack should unanticipated extubation occur during the procedure.<br />

At this time, the dentist must remove all of his/her dental<br />

equipment and the anesthesiologist may attempt positive pressure<br />

mask ventilation prior to throat pack removal. Clearly, ventilation<br />

will be suboptimal. To minimize this occurrence, many institutions<br />

have devised methods to remind them of the intact throat<br />

pack. Some of the suggestions have been to: 29–31<br />

1. Leave part of the throat pack outside the mouth<br />

2. Tie a piece of dental floss to the pack and tape the floss to<br />

the face<br />

3. Tie part of the throat pack to the tracheal tube<br />

4. Tape a sign to the forehead<br />

5. Tape a sign to the ventilator switch<br />

6. Have the person responsible for placing the tube be the one<br />

who removes the pack<br />

7. Have all members of the team witness the removal of the pack<br />

8. Include the pack as part of the scrub nurse’s count<br />

9. Visually inspect the pharynx with the laryngoscope prior to<br />

extubation<br />

Using a throat pack with a radio-opaque lining (Figure <strong>126</strong>–8)<br />

would be advisable and can be helpful in cases where the pack has<br />

become unaccounted for and an x-ray is needed to determine<br />

whether it was left in the patient. 28<br />

Surgical Issues and Pain Management<br />

Typically, restorative dentistry on pediatric patients under general<br />

anesthesia does not require local anesthesia. Local anesthesia with<br />

epinephrine may allow improved hemostasis for extractions,<br />

however. The most stimulating procedures for the pediatric<br />

patient intraoperatively are placement of the rubber dam, where<br />

the oral cavity and tongue are stretched; removal of the dental pulp<br />

(pulpotomy); and extractions. It is helpful for the dentist to alert<br />

the anesthesiologist to these procedures.<br />

Regardless of whether or not extractions are performed<br />

during the dental procedure, the dental patient still requires<br />

postoperative pain management. Placement of stainless steel<br />

crowns can be very painful for the child, because the crowns are<br />

placed well under the gum line and can fit together very tightly.<br />

The dentist may use local anesthesia intraoperatively, which may<br />

provide acceptable pain control postoperatively. Many dentists,<br />

however, do not wish to give local anesthesia, particularly to<br />

younger children who may bite their lips, cheeks or tongue, as this<br />

can lead to severe mutilation of the oral soft tissues. NSAIDs are<br />

effective in controlling mild to moderate levels of dental pain 32<br />

and are a good choice for pain management in dental patients.<br />

Ketorolac tromethamine, a parenterally available NSAID, has been<br />

shown to be very effective in the management of dental pain.<br />

Purday et al. showed no difference between intravenous ketorolac<br />

and morphine for postoperative pain in children undergoing<br />

dental surgery, with the added benefit of reducing postoperative<br />

nausea and vomiting in the 24-hour postoperative period. 33 Dsida<br />

et al. showed that 0.5 mg/kg of I.V. ketorolac in children produced<br />

plasma blood levels similar to adults for therapeutic concentrations.<br />

34 Some pediatric hospitals allow 1 mg/kg of I.V. ketorolac<br />

as a single dose followed by acetaminophen for continued postoperative<br />

pain control. Opioids can also be considered, with the<br />

most commonly used being morphine sulfate at a dose of 0.05 to<br />

0.1 mg/kg.<br />

Extubation<br />

If oral bleeding or heavy secretions are expected at case completion,<br />

deep extubation may lead to an increased risk of<br />

laryngospasm during anesthetic emergence. Additionally, extubation<br />

of a nasotracheal tube may lead to nasal bleeding into the<br />

oral cavity, with increased risk of laryngospasm if deep extubation<br />

is planned. This can occur despite apparent atraumatic intubation.<br />

Epistaxis can also occur. Nasal bleeding may have an anterior or<br />

posterior component. The use of ketorolac tromethamine may


2088 PART 5 ■ Anesthetic, Surgical, and Interventional Procedures: Considerations<br />

exacerbate this adverse event. Frequently, placement of a soft<br />

nasopharyngeal airway can temporarily tamponade nasal bleeding<br />

and allow for hemostasis to take place. In rare cases, a nasal<br />

tampon (Merocel or Doyle sponge; Laubscher, Germany) may be<br />

needed. Uncontrolled posterior bleeding is usually controlled with<br />

a balloon catheter and provided by an otolaryngologist.<br />

In summary, the anesthesiologist should consult as needed with<br />

the dentist preoperatively regarding behavioral challenges, type of<br />

intubation needed, and any airway concerns that the anesthesiologist<br />

may recognize, as well as postoperative pain control choices<br />

to provide optimal patient care.<br />

POSTOPERATIVE CONSIDERATIONS<br />

Some unique postoperative considerations may be associated with<br />

anesthesia for dental or oral surgery in addition to typical postoperative<br />

complications. These include:<br />

1. Increased incidence of postoperative nausea and vomiting<br />

during oral and maxillofacial surgery due to passive ingestion<br />

of blood during the procedure or active swallowing of blood<br />

during recovery.<br />

2. Miscellaneous dental debris inadvertently left behind after the<br />

completion of the procedure and possibly aspirated during<br />

extubation. Dental debris left behind by the surgeon and/or<br />

assistant can include but are not limited to such items as cotton<br />

pellets, pieces of amalgam or other dental filling materials,<br />

stainless steel crowns, other small dental equipment and/or<br />

pieces of a tooth.<br />

3. Retained throat pack; this has the potential to be swallowed or<br />

to obstruct the patient in recovery.<br />

4. Although maxillomandibular fixation is not used as frequently<br />

as in the past for jaw fracture, if this has occurred, immediate<br />

availability of wire scissors and other instruments for<br />

immediate release of fixation should be available in the<br />

recovery room.<br />

AMBULATORY SURGERY IN THE<br />

OFFICE VS HOSPITAL/AMBULATORY<br />

SURGERY CENTER<br />

Office-based general anesthesia started with dentists, Horace<br />

Wells and William T.G. Morton, who discovered nitrous oxide and<br />

ether anesthesia, respectively. Later, with the introduction of<br />

intravenous barbiturates, oral surgeons were the leaders for many<br />

years in intravenous office-based anesthesia, promoting the<br />

methohexital bolus technique for short tooth extraction procedures<br />

long before the medical community was comfortable with<br />

office-based anesthesia and surgery. Today, with improved anesthetic<br />

medications and monitoring techniques, there is an<br />

increasing trend toward office-based surgery in both medicine and<br />

dentistry, paralleling the increase in overall outpatient surgery to<br />

greater than 75% of total surgical procedures. 35 In the United<br />

States, this is driven mainly by cost considerations, with unique<br />

circumstances for dentistry. Many U.S. medical insurance plans<br />

do not reimburse for anesthesia, facility fees, and additional<br />

routine hospital/ASC charges for needed dental procedures as they<br />

do for medical procedures. This is particularly problematic for the<br />

pediatric patient who is unable to cooperate with delicate dental<br />

treatment on very small oral structures. With the average global<br />

cost of a 2-hour operating room visit, excluding the dental charges,<br />

ranging from $8000 to $12,000, many parents are unable to<br />

afford this expense. The child frequently lives with chronic dental<br />

pain 36 or eventually may find an oral surgeon willing to provide<br />

operator–anesthetist general anesthesia or sedation for extraction<br />

of abscessed teeth, the only procedure the oral surgeon is trained<br />

to provide. In other countries, such as Canada and the United<br />

Kingdom, there may be long waits for treatment resulting in<br />

continued patient suffering, lost time from school, and in some<br />

cases, hospitalization due to facial cellulitis formation. 36<br />

With the increasing number of dentist anesthesiologists providing<br />

anesthesia services in the dental office, as well as physician<br />

anesthesiologists gradually making their way into the office venue,<br />

more parents and pediatric patients are able to afford dental care<br />

under general anesthesia as there are no facility fees. Anesthesia<br />

costs for a 2-hour case range from $750 to $1500 depending on<br />

the region of the United States and exclusive of dental surgical<br />

costs. For pediatric patients, these office procedures are usually<br />

for routine dental care and limited dentoalveolar surgery, such as<br />

extraction of impacted teeth.<br />

Anesthesiologists who provide treatment in dental offices many<br />

times do not have the “luxury” of an anesthesia machine. Most<br />

commonly, general anesthesia is provided via a total intravenous<br />

anesthesia (TIVA) technique with an unsecured airway but with a<br />

gauze throat partition to minimize the risk of small objects and<br />

fluids reaching the hypopharynx. Anesthesia for uncooperative<br />

pediatric patients, for whom obtaining I.V. access is challenging,<br />

is most commonly induced with 2 to 3 mg/kg or more of ketamine<br />

I.M., frequently with the addition of midazolam and possibly an<br />

anticholinergic. This allows for adequate dissociation within 3 to<br />

6 minutes in order to place monitors, establish I.V. access, position<br />

the patient with a shoulder roll to maintain airway patency, and<br />

allow incremental doses or a continuous infusion of propofol to be<br />

used. Local anesthesia of the oral cavity is used, except for very<br />

short or relatively nonstimulating procedures, minimizing anes -<br />

thetic requirements as surgical stimulation is kept to a minimum.<br />

Variations of this technique include the use of bolus opioids or<br />

remifentanil infusion in combination with propofol or ketamine<br />

with propofol. At times, a nasopharyngeal airway is used to help<br />

maintain airway patency and an LMA can be considered. Where<br />

I.V. access can be obtained, frequently with nitrous oxide–oxygen<br />

or oral midazolam premedication for younger children, with or<br />

without common topical skin anesthetics, I.V. induction can be<br />

performed.<br />

Because most dental offices have a nitrous oxide delivery<br />

system, an intubated, nontriggering, TIVA technique can also be<br />

provided, using this gas delivery system with a single limb circuit<br />

or with specialized disposable carbon dioxide absorbers, which<br />

allow a circle system. If nitrous oxide is used, proper scavenging<br />

must be maintained. Alternatively, a flexible LMA can be used,<br />

with or without nitrous oxide, to aid in securing the airway.<br />

As with all office-based surgery, patient selection, surgeon<br />

selection, and surgical procedure determine the anticipated safety<br />

of providing general anesthesia in this setting. Patients are<br />

generally American Society of Anesthesiologists (ASA) classification<br />

I or II, but select ASA III patients, generally without<br />

cardiopulmonary compromise, can also be considered. For<br />

instance, a patient with persistent seizures despite optimal treatment,<br />

but for whom the neurologist would not admit the patient<br />

after general anesthesia, may be quite acceptable for anesthesia in<br />

the office setting with an adequate postoperative observation<br />

period. Alternatively, a child with obstructive sleep apnea<br />

secondary to tonsillar hypertrophy who is ASA II may not be a


CHAPTER <strong>126</strong> ■ Dental Procedures: Anesthetic Considerations 2089<br />

good candidate for a an in-office nonintubated general anesthetic.<br />

Regarding surgeon/dentist selection, the nuances of working<br />

within a relatively unprotected airway requires some understanding<br />

and modification of surgical technique, such as minimal<br />

use of water spray to cool the tooth while drilling, which may<br />

migrate to the glottis and lead to laryngospasm. Additionally, there<br />

can be considerable differences in anesthesia time with slower<br />

versus faster surgeons. Lastly, some procedures, such as more complex<br />

maxillofacial procedures, may require intubation and preferably<br />

potent inhalation agents or mechanical ventilation, thus<br />

necessitating a formal operating room suite with full anesthesia<br />

capabilities. Regardless of the surgical procedure, provision should<br />

be made for duplicates of all critical pieces of equipment, both for<br />

anesthesia and surgery, should some device fail prior to procedure<br />

completion. Lastly, should a surgical or anesthetic complication<br />

arise which necessitates transfer to the hospital, arrangements<br />

should be made in advance for how and where this will be<br />

accomplished.<br />

SUMMARY<br />

General anesthesia for dental and oral surgery is frequently<br />

necessary for uncooperative patients, patients for whom local<br />

anesthesia is difficult to obtain, procedures of significant surgical<br />

complexity, or when local anesthesia cannot be obtained. Particularly<br />

for pediatric patients, there is an increasing use of hospital<br />

and office-based general anesthesia for dental procedures. The<br />

anesthesiologist is faced with the challenge of sharing the airway<br />

with the dentist/surgeon and the frequent need for nasotracheal<br />

intubation. Proper preoperative planning and consultation with<br />

the dentist/surgeon will enhance the safe and comfortable<br />

administration of anesthesia for the patient and dentist.<br />

REFERENCES<br />

1. Bankoff G. The Conquest of Pain: The Story of Anesthesia. London:<br />

MacDonald; 1946.<br />

2. Malamed SF. Medical Emergencies in the Dental Office. 6th ed. St. Louis:<br />

Mosby-Year Book; 2008.<br />

3. Weaver J. Changing of the guard in Pittsburgh: C. Richard Bennett, DDS,<br />

PhD, retires. Anesth Prog. 2006;53(3):77.<br />

4. Calatayud J, Gonzalez A. History of the development and evolution of local<br />

anesthesia since the coca leaf. Anesthesiology. 2003;98(6):1503–1508.<br />

5. American Dental Association. Accreditation standards for advanced<br />

specialty education programs in pediatric dentistry. Available at: http://<br />

www.ada.org/prof/ed/accred/standards/ped.pdf. Accessed September 3,<br />

2010.<br />

6. Bohaty B, Spencer P. Trends in dental treatment under general anesthesia,<br />

1978–1990. J Clin Pediatr Dent. 1992;16:222–224.<br />

7. American Society of Anesthesiologists. The medical specialty of anes -<br />

thesiology. Available at: http://www.asahq.org/patientEducation/specialty.<br />

htm. Accessed September 3, 2010.<br />

8. Postillo D. General anesthesia, sedation and resuscitation in dentistry.<br />

Report of an expert working party for the standing dental advisory<br />

committee. London: Department of Health; 1990.<br />

9. Flick WG, Katsnelson A, Alstrom H. Illinois Dental Anesthesia and<br />

Sedation Survey for 2006. Anesth Prog. 2007;54:52–58.<br />

10. Koch ME, Barinholtz D. Office-based anesthesia: an overview. Anesthesiol<br />

Clin North Am. 2003;21(2):417–443.<br />

11. Brennan LJ, Watson B. Modern day-case anaesthesia for children. Br J<br />

Anaesth. 1999:83–91.<br />

12. McGraw T, Kendrick A. Oral midazolam premedication and postoperative<br />

behaviour in children. Paediatr Anaesth. 1998;8(2):117–121.<br />

13. Wilson W, TK, Gewitz M, et al. Prevention of infective carditis. Guidelines<br />

from the American Heart Association. Circulation. 2007;116:1736–1754.<br />

14. Baddour LM, Wilson WR, Bayer AS, et al. Nonvalvular cardiovascular<br />

device-related infections. AHA Statement. Circulation. 2003;108:2015–<br />

2031.<br />

15. ADA/AAOS advisory statement. Antibiotic prophylaxis for dental<br />

patients with total joint replacements. The evidence base for the efficacy<br />

of antibiotic prophylaxis in dental practice. J Am Dent Assoc. 2007;<br />

138:458–474.<br />

16. Brimacombe J, BA. The laryngeal mask airway for dental surgery—a<br />

review. Aust Dent J. 1995;40(1):10–14.<br />

17. Bennett J, Petito A, Zandsberg S. Use of the laryngeal mask airway in oral<br />

and maxillofacial surgery. J Oral Maxillofac Surg. 1996;54(11):1346–1351.<br />

18. Hee HI, Conskunfirat ND. Airway management in a patient with a cleft<br />

palate after pharyngoplasty: a case report. Can J Anaesth. 2003;50(7):721–<br />

724.<br />

19. Marlow TJ, Goltra DD Jr, Schabel SI. Intracranial placement of a<br />

nasotracheal tube after facial fracture: a rare complication. J Emerg Med.<br />

1997;15(2):187–191.<br />

20. Harvey DC, Amorosa P. Traumatic nasotracheal intubation. Anaesthesia.<br />

1986;41(4):442.<br />

21. Williams AR, Burt N, Warren T. Accidental middle turbinectomy: a<br />

complication of nasal intubation. Anesthesiology. 1999;90(6):1782–1784.<br />

22. Knuth TE, Richards JR. Mainstem bronchial obstruction secondary to<br />

nasotracheal intubation: a case report and review of the literature. Anesth<br />

Analg. 1991;73(4):487–489.<br />

23. Elwood T, Stillions DM, Woo DW, et al. Nasotracheal intubation: a<br />

randomized trial of two methods. Anesthesiology. 2002;96(1):51–53.<br />

24. Elwood T, Parker S, Ramamoorthy C. Pediatric-nasotracheal intubation<br />

made atraumatic. Anesthesiology. 1998;89(2):550.<br />

25. Kim YC, Lee SH, Noh GJ, et al. Thermosoftening treatment of the<br />

nasotracheal tube before intubation can reduce epistaxis and nasal<br />

damage. Anesth Analg. 2000;91(3):698–701.<br />

26. Katz RI, Hovagim AR, Finkelstein HS, et al. A comparison of cocaine,<br />

lidocaine with epinephrine, and oxymetazoline for prevention of epistaxis<br />

on nasotracheal intubation. J Clin Anesth. 1990;2(1):16–20.<br />

27. Hung OR, Stewart RD. Lightwand intubation: I—a new lightwand device.<br />

Can J Anaesth. 1995;42(9):820–825.<br />

28. To EW, Tsang WM, Yiu F, et al. A missing throat pack. Anaesthesia.<br />

2001;56(4):383–384.<br />

29. Crawford BS. Prevention of retained throat pack. BMJ. 1977;2(6093):1029.<br />

30. Stone JP, Collyer J. Aide-memoir to pharyngeal pack removal. Anesth<br />

Analg. 2003;96(1):304.<br />

31. Knepila GJ, Blackburn CW. Retained throat packs: results of a national<br />

survey and the application of an organisational accident model. Br J Oral<br />

Maxillofac Surg. 2008;46:473–6.<br />

32. Haas DA. An update on analgesics for the management of acute<br />

postoperative dental pain. J Can Dent Assn. 2002;68(8):476–482.<br />

33. Purday JP, Reichert CC, Merrick PM. Comparative effects of three<br />

doses of intravenous ketorolac or morphine on emesis and analgesia<br />

for restorative dental surgery in children. Can J Anaesth. 1996;43(3):<br />

221–225.<br />

34. Dsida RM, Wheeler M, Birmingham PK, et al. Age-stratified pharmacoki -<br />

netics of ketorolac tromethamine in pediatric surgical patients. Anesth<br />

Analg. 2002;94(2):266–270.<br />

35. RK S. Office-based anesthesia growth provokes safety fears. Anesth Patient<br />

Safety Found Newsletter. 2000;15(1):1.<br />

36. North S, Davidson LE, Blinkhorn AS, Mackie IC. The effects of a long wait<br />

for children’s dental general anesthesia. Int J Paediatr. 2007;17:105–109.

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