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“These data suggest that Tween 80 has an effect on the Central Nervous System<br />

which could lead to misinterpretation of results in toxicology studies<br />

that use this compound as a dosage vehicle.”<br />

Life Sciences • June 1982<br />

Effect of Tween 80<br />

on exploratory behavior and locomotor activity in rats<br />

Brubaker CM, Taylor DH, Bull RJ.<br />

Abstract<br />

Exploratory behavior and locomotor activity is enhanced in male rat pups (aged 10<br />

to 20 days) whose dams received a chronic dose (1.25 ml/l) of Tween 80 via their<br />

drinking water. This enhancement manifests itself during the diurnal period of the<br />

day. These data suggest that Tween 80 has an effect on the CNS which could lead<br />

to misinterpretation of results in toxicology studies that use this compound as a<br />

dosage vehicle.<br />

http://www.ncbi.nlm.nih.gov/pubmed/7202094

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