VACCINE

Journal Of Hygiene Research • May 2005
Effect of formaldehyde
on energy metabolism in
postnatal rat cortex neurons in culture
Author information
Liu T1, Bai XT.
Department of Toxicology
Institute of Environment Health and Related Product Safety
China CDC, Beijing 100021, China
Abstract
OBJECTIVE:
The mechanism of the effect of formaldehyde on CNS
which is much concerned to formaldehyde poisoning was studied.
METHODS:
In the present study, incubation of postnatal rat cortex neurons in culture with
formaldehyde at 1, 2, 4, 8 mg/L (medium) was carried out to evaluate the effect
of formaldehyde on energy metabolism.
RESULTS:
The result of cytochemistry showed a significant down-regulation of cytochrome
oxidase activity after consecutive formaldehyde treatment for 4 hours
compared with the control (P < 0.01), the significant dosage-response relationship
was also observed (R value is - 0.92, P < 0.01).
CONCLUSION:
The result demonstrates that excessive exposure of formaldehyde can decrease
cytochrome oxidase activity in cortex neurons which indicates energy metabolism
will be decreased and therefore normal physiology function would be
damaged.
“The result demonstrates
that excessive exposure of
formaldehyde can decrease
cytochrome oxidase activity
in cortex neurons which indicates
energy metabolism will be decreased
and therefore normal physiology
function would be damaged.”
http://www.ncbi.nlm.nih.gov/pubmed/?term=16111027