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“Aluminium intoxication ... is associated with periorbital bleeding, lethargy, anorexia, and death.
It is recommended that aluminium salts should be withdrawn from use in patients with renal failure
and their use restricted in normal persons pending clarification of the issue.”
The Lancet • Volume 299, No. 7750, p564–568 • March 1972
Aluminium Toxicity In Rats
G.M. Berlyne, J. Ben Ari, E. Knopf, R.
Yagil, G. Weinberger, G.M. Danovitch
Department of Nephrology
Negev Central Hospital and Division of Life Sciences
Negev Arid Zone Research Institute and Faculty of Natural Science
University of Negev, Beer Sheva, Israel
Abstract
Aluminium intoxication has been demonstrated in the uræmic and non-uræmic rat after modest doses of oral and
parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and
death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain,
and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the
animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended
that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted
in normal persons pending clarification of the issue.
http://www.ncbi.nlm.nih.gov/pubmed/4110051