VACCINE

Der Unfallchirurg • December 2012
Persistent swelling
after flushing of an abscess with Octenisept
Author information
Bauer B1, Majic M, Rauthe S, Bröcker EB, Kerstan A.
Klinik und Poliklinik für Dermatologie
Venerologie und Allergologie
Universitätsklinkum Würzburg
Josef-Schneider-Straße 2, 97080
Würzburg, Deutschland
Bauer_B1@klinik.uni-wuerzburg.de
Abstract
We report the case of a long-lasting cutaneous side effect after inappropriate
use of Octenisept® solution (containing octenidine and phenoxyethanol).
Following lavage of an abscess in the inguinal region, a painful erythematous
induration mimicking cellulitis persisted for several months.
Manual lymphatic drainage considerably improved the symptoms. Octenisept®
shows considerable tissue toxicity in vivo including - but not
restricted to - blood vessel damage. Deterioration of endothelial cells followed
by oedema and continued tissue damage can be seen histologically.
Despite the fact that there is a circular letter issued by the manufacturer as
well as a boxed warning on the bottles, the awareness to avoid this misuse
of Octenisept® is still lacking.
“Octenisept® solution
(containing octenidine and phenoxyethanol) ...
shows considerable tissue toxicity in vivo including -
but not restricted to - blood vessel damage.
Deterioration of endothelial cells followed by
oedema and continued tissue damage can
be seen histologically.”
[phenoxyethanol is a vaccine ingredient]
http://www.ncbi.nlm.nih.gov/pubmed/?term=22101779