VACCINE

Pharmacology And Toxicology • April 1992
Aluminium-adjuvanted vaccines
transiently increase aluminium levels
in murine brain tissue
Author information
Redhead K1, Quinlan GJ, Das RG, Gutteridge JM.
Division of Bacteriology
National Institute for Biological Standards and Control
Herts., UK
Abstract
Aluminium is widely used as an adjuvant in human vaccines, and children can
often receive up to 3.75 mg of parenteral aluminium during the first six months
of life. We show that intraperitoneal injection of aluminium adsorbed vaccines
into mice causes a transient rise in brain tissue aluminium levels peaking around
the second and third day after injection. This rise is not seen in the saline control
group of animals or with vaccine not containing aluminium. It is likely that
aluminium is transported to the brain by the iron-binding protein transferrin and
enters the brain via specific transferrin receptors.
“... children can often receive up to 3.75 mg
of parenteral aluminium during the first six months of life
We show that intraperitoneal injection of aluminium
adsorbed vaccines into mice causes a transient rise in
brain tissue aluminium levels peaking around the
second and third day after injection.”
http://www.ncbi.nlm.nih.gov/pubmed/1608913