Monday, 1 September 2008 - European Heart Journal

264 New prognostic markers in acute cardiac care / Resuscitation resuscitated!
Conclusion: Patients presenting with acute dyspnea at the ED, with a positive
cTnT were at a very high risk of in-hospital death. Cardiac troponin T positivity
was an independent predictor of in-hospital death, whereas NT pro-BNP was not.
1647 N-terminal pro-B-type natriuretic peptide changes in
patients with acute coronary syndromes
K. Shreyder, R. Shakhnovich, E. Bosikh, M. Ruda. National Cardiology
Research Center, Intensive Cardiology, Moscow, Russian Federation
The purpose of the study was to determine NT-proBNP dynamics in
different treatment strategies in patients with acute coronary syndromes (ACS).
Materials and methods: 52 patients with ST-elevation myocardial infarction
(STEMI) and 61 patients with non-ST-elevation ACS (NSTACS) were included
into the study. NT-proBNP was measured in admission, on the 3d day and before
discharge (7-12 days).
Results: In NSTACS baseline concentration of NT-proBNP was higher than
in STEMI group (751,1 vs. 449,9pg/ml, p=0,05). NT-proBNP level increases
markedly in STEMI during hospitalization and achieves peak at discharge. In
NSTACS baseline concentration of NT-proBNP is the highest and decreases towards
discharge (figure). In STEMI patients with pre-hospital thrombolysis baseline
NT-proBNP level is lower than in cases with in-hospital treatment (140,9 vs.
543,1 pg/ml, p=0,05). The peak concentration of NT-proBNP at discharge was
in the facilitated PTCA group, when compared with pre-hospital thrombolysis, inhospital
thrombolysis and primary PTCA. NT-proBNP was lower in patients with
reperfusion before 4 hours than in cases with later reperfusion (1150,5 vs 2130,2
pg/ml, p