Monday, 1 September 2008 - European Heart Journal

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$Heart failure with preserved ejection fraction - European Heart Journal$

296 Atrial fibrillation ment. Platelet P-selectin, platelet-leukocyte conjugates and leukocyte activation markers were measured by flow-cytometry in basal conditions and after in vitro ADP/collagen challenge. Plasma D-dimer, soluble P-selectin, IL-6 and ICAM-1 were measured by ELISA. Results: In AF patients before parnaparin, platelet count and platelet P-selectin expression were lower than in controls, while both soluble P-selectin and D-dimer higher. Both basal and stimulated platelet-leukocyte conjugates were lower in AF; leukocyte activation markers and cytokines were unchanged (Table). Parnaparin significantly reduced D-dimer (to 192±7, p
hydrolysable, it would dissipate before the more tonic, proarrhythmic effects could take hold. Methods: Sustained AF episodes, lasted on average 8.6±2.2 min (n=32), were elicited in anesthetized Wistar rats by programmed electrical stimulation via transesophageal catheter. Rats were randomly and blindly assigned with a model drug, acetylcholine (ACh, n=17), or saline injection (n=15) either via the tail vein or into the right ventricular cavity, three minutes after the AF initiation. Results: Intravenous injection of a model hydrolysable muscarinic agonist, acetylcholine (0.2 mg/kg body weight), converted AF into sinus rhythm within 8.4±1.9 sec (n=10, p < 0.0001). The termination of AF episode was always accompanied with transient bradycardia; the sinus rhythm gradually accelerated and reached its pre-AF values within 10-20 sec following the injection. Conclusion: Our evidence indicates that bolus administration of rapidly hydrolysable muscarinic agonist could be an effective way for pharmacological conversion of atrial fibrillation into the sinus rhythm. P1942 Non-linear heart rate dynamics before sudden-onset episodes of paroxysmal atrial fibrillation H. Bonnemeier1 ,F.Kurz2 , M. Barantke 2 , U.K. Wiegand2 , H. Schunkert 2 . 1Universitaet zu Luebeck, Medizinische Klinik II, Luebeck, Germany; 2Luebeck, Germany Introduction: Beside bradycardia-, tachycardia- and ectopy-related initiation of paroxysmal atrial fibrillation (pAF), those episodes without preceding rate or rhythm changes (i.e. sudden onset (SO) episodes) are particulary interesting for the investigation of autonomic fluctuations before spontaneous onset of pAF. We hypothesized that there are significant alterations of beat-to-beat RR-interval fluctuations before SO-pAF and tested this assumption in a large patient population using parameters of non-linear heart-rate dynamics. Methods: From a total of 20.546 consecutive Holter-recordings, 715 episodes of pAF were identified in 350 patients. Detrended fluctuation analysis (DFA), approximate entropy (APEn), and parameters of heart rate variability (HRV) were analysed in 5-minute-segments before SO-pAF, and during AF-free day- and nighttime. Results: A dominant portion of pAF onsets were SO-episodes (n=276; 39%), 299 (41%) ectopy-related, and 140 (20%) heart rate related. Time domain HRV (SDNNi, SDANN, rMSSD, TI) significantly increased before pAF-onset. The low frequency component (LF), the LF/HF-ratio, the Poincaré-SD2, and DFA also increased before pAF-onset, whereas APEn significantly decreased. Conclusions: In this first study providing detailed analysis of heart-rate dynamics preceding SO-pAF-episodes, we were able to demonstrate that there are significant pertubations of autonomic modulation preceding SO-pAF. These transient abnormal changes of cardiac autonomic nervous control may predispose to the development of pAF. P1943 Analysis of atrial fibrillation episode after catheter ablation of atrial fibrillation: long-term results of received technology A. Romanov, E. Pokuschalov, A. Turov, S. Artemenko, P. Shugaev, V. Shabanov, I. Stenin, D. Elesin, N. Shirokova, V. Selina. Research Institute of Circulation Pathology, Novosibirsk, Russian Federation Purpose: The objective of this study was to assess the time course of atrial fibrillation (AF) episodes before and after left atrial ablation and the percentage of patients with complete freedom from AF after ablation by using continuously monitors a patient’s ECG. Methods: A total of 45 consecutive patients with highly symptomatic drug refractory PAF (age, 52±10 years) underwent catheter ablation. The Insertable Cardiac Monitor was implanted to all patients at least 5 days immediately before the ablation. 14 patients underwent PV isolation by segmental ostial catheter ablation (SOCA), 16 patients underwent left atrial catheter ablation (LACA) to encircle the Atrial fibrillation / Perspectives in heart failure treatment 297 PVs and 15 patients underwent left atrial GP ablation. During SOCA, ostial PV potentials recorded with a ring catheter were targeted. LACA was performed by encircling the left- and right-sided PVs 1 to 2 cm from the ostia and was guided by an electroanatomic mapping system; ablation lines also were created in the mitral isthmus and posterior left atrium. Target sites for GP ablation were defined using the data of their anatomical location. Symptom-based monitoring was approximated by analyzing days when patients indicated symptoms with an external activator. Results: A total of 4119 days were monitored. Out of the total 390 events triggered by patient’s symptoms, 31% were confirmed as AF events (89) and 69% were confirmed as non-AF events (198). Before ablation, 36 of 45 patients (80%) had documented AF episodes. All episodes were symptomatic in 15 patients (41,7%). In 20 patients (44,4%), both symptomatic and asymptomatic episodes were recorded, whereas in 1 patients (2,7%) all documented AF episodes were asymptomatic. After ablation, the percentage of patients with only asymptomatic AF recurrences increased to 42% (P
Page 1 and 2: Monday, 1 September 2008 Downloaded
Page 3 and 4: CAN WE PREDICT ATRIAL FIBRILLATION?
Page 5 and 6: Thromboembolic risks and therapeuti
Page 7 and 8: Healthy bone marrow for a healthy h
Page 9 and 10: NEW PROGNOSTIC MARKERS IN ACUTE CAR
Page 11 and 12: CI 0.2-1.6, p=0.32) after epinephri
Page 13 and 14: Risk assessment: strengths and weak
Page 15 and 16: Prognosis in heart failure: surveys
Page 17 and 18: Restenosis: is there an alternative
Page 19 and 20: Confonding factors influencing outc
Page 21 and 22: New vessels and changed vessels: an
Page 23 and 24: (n=574) served as the cohort where
Page 25 and 26: Using Cox’s proportional hazards
Page 27 and 28: hibitory response, or in pts with p
Page 29 and 30: Multimodality imaging of coronary h
Page 31 and 32: Conclusions: EVH is a strong indepe
Page 33 and 34: any antiarrhythmic drug (AAD), Grou
Page 35 and 36: oxidases decreased O2- by 16±3.1%
Page 37 and 38: Fig. 1. Five types of merge errors.
Page 39 and 40: manent AF were studied. The number
Page 41: P1933 Left atrial appendage dominan
Page 45 and 46: P1949 A first-in-human clinical tri
Page 47 and 48: P1957 Electrophysiological effects
Page 49 and 50: for the population of Tayside, Scot
Page 51 and 52: P1973 Effect of ursodeoxycholic aci
Page 53 and 54: =0.31, p=0.0003) and QUICKI (r=0.29
Page 55 and 56: P1989 Hormonal mechanisms of cachex
Page 57 and 58: or more of the following ECG change
Page 59 and 60: P2004 Association between cardiovas
Page 61 and 62: P2012 Correlations between the degr
Page 63 and 64: disease. Familial study was recomen
Page 65 and 66: P2027 MRI for the detection of rest
Page 67 and 68: P2035 Oxidized low density lipoprot
Page 69 and 70: P2042 Persistent under representati
Page 71 and 72: P2049 Addition of B-type natriureti
Page 73 and 74: P2058 Genetic variation in CYP2C19
Page 75 and 76: p=0.003). Minor bleeding was also l
Page 77 and 78: Avidin, a protein found in hen eggs
Page 79 and 80: flow, and
Page 81 and 82: (PCWP) were recorded. In 16 patient
Page 83 and 84: Methods: A prospective, consecutive
Page 85 and 86: over paclitaxel-eluting stent (PES)
Page 87 and 88: which proved to be safe and effecti
Page 89 and 90: Comparison of neointimal growth amo
Page 91 and 92: patients between October 2006 and J
Page 93 and 94:
P2139 Inverse relation of baseline
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tive. We sought to determine the ef
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P2155 A very high prevalence of low
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P2163 The influence of estradiol on
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2nd year of follow-up, respectively
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P2179 Symptoms of atrial fibrillati
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P2187 The relationships of ambulato
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tension (WCHT) to vascular damage i
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in the postero- and midseptal regio
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elevation myocardial infarction (AM
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assigned to receive either unselect
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was injected. Left ventricular func
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of MACE in patients with LGE and de
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P2243 Blood oxygenation level-depen
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P2250 Prognostic value of revascula
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needed to achieve 90% of age-predic
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presence/absence of VIVC assessed u
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2341 Telemonitoring in an elderly,
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Heart failure with preserved systol
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the most dilated, LA mostly influen
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Conclusion: In patients with stable
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2388 Magnitude of glycaemia variati
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patients with RV > 30 ml this corre
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BIOMARKERS: NEW KIDS ON THE BLOCK 2
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the importance of calling the emerg
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Sudden death, devices and public aw
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Bone marrow progenitors: filling th
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2566 Esophageal capsule endoscopy i
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(7.0%) patients receiving aliskiren
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P2600 Final aggregation response is
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Results: Female patients (27.7%) we
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with atrial fibrillation (AF) under
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e feasible and safe. This approach
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coagulant therapy (P=0.038; OR=2.42
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ison between responders and nonresp
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Table 1. Systolic, diastolic and dy
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Syncope and cardiac pacing: miscell
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their downstream effector, myosin h
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Understanding determinants of hemod
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the abundance of profibrotic CCN2 p
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parison with IL-8 as well as the ex
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and EF (-0.5%) which significantly
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of effects on systemic BP and cardi
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Conclusion: Compared to previously
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P2723 Differential virus-associated
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Methods: During 2007, 10 patients (
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cardiomyocyte apoptosis was highest
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higher for NT-proBNP (area under th
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or higher) in 85 patients (4.2%). M
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teria as a final Thrombolysis In My
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cantly correlated to in-hospital de
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nosis in patients with myocardial i
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lesion classification, stent type u
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Prognosis in ST-elevation myocardia
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P2802 In-hospital and long-term mor
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P2810 Long-term clinical results fo
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Percutaneous coronary intervention;
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vessels (DES 16.7%, BMS 6.7%, p=0.0
Page 209 and 210:
patients receiving a DES and the ra
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Results: The two groups had similar
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among their non-DM counterparts (HR
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tigated the long-term consequences
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culogenesis. Reduction of VPC and E
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y echo-tracking technique calibrate
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P2885 Statins are effective in redu
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Conclusions: The patient-centred he
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P2900 Should left ventricular hyper
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P2908 Telmisartan up-regulates the
Page 229 and 230:
important sex-based differences in
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Hypertension: regional and ethnic p
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whether the selective mineralocorti
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THE ENDOTHELIUM: AT THE HEART OF VA
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P2951 Reproducibility of endothelia
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P2959 Brachial flow-mediated dilati
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P2966 Detection of late enhancement
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tissue as an enhanced area. On the
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dial dysfunction is critical for th
Page 247 and 248:
for testing the load dependence. Th
Page 249:
diastolic velocity (-12.3±4.9 vs -
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Monday, 1 September 2008 - European Heart Journal

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