Monday, 1 September 2008 - European Heart Journal

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$Heart failure with preserved ejection fraction - European Heart Journal$

290 Atrial fibrillation cardioverted episode of persistent LAF, appear to be early and reliable predictors of SR maintenance during the following year. P1911 Transoesophageal echocardiographic findings in patients with persistent atrial fibrillation at low risk for stroke (CHADS 0 or 1) I. Karnialiuk, I. Aliakseyeuskaya, M. Belskaya, Y. Persidskikh. The Center of Cardiology, Minsk, Belarus Purpose: Atrial fibrillation (AF) promotes the development of atrial thrombus (AT), which can be revealed by transoesophageal echocardiography (TOE). This study was aimed to compare various echocardiografic parameters, assessed during transthoracic (TTE) and TOE in two groups of patients divided according to the detection of thrombus in left atrial appendage (LAA). Methods: TTE and TOE were performed in 56 patients with persistent nonrheumatic AF at low risk for stroke (CHADS 0-1), who were planned to undergo electrical cardioversion. The following parameters were analyzed: left atrial diameter (LA), left ventricular endsystolic and enddiastolic diameter (LVes, LVed), ejection fraction (EF). The presences of spontaneous echocontrast (SEC), LAA area and flow velocity in the LAA (LAAa, LAA-flow) were measured during TOE. Results: A thrombus was detected in 20 patients (35.7%) in the LAA. Out of these patients, 85.0% vs. 16.7% of patients without thrombus showed moderate or severe SEC (p
Fig. 1. Five types of merge errors. nical match errors (10 errors, 43%), position change due to movement (5 errors, 21.7%), volume discrepancy with the CT and 3D map (4 errors, 17.4%), rotational disarrangement (3 errors, 13.0%), and a bad CT image (1 error, 4.3%) (Figure 1). A significant correlation between the LA size and match statistic data was determined (r = 0.382, p = 0.01). Excluding patient movement, the match statistic data showed a significant correlation with the LA size (r = 0.382, p = 0.002) and practical match accuracy (r = -0.276, p = 0.026). Conclusion: Although CARTO-Merge is very useful tool for AF ablation, for accurate integration, more detailed mapping needs to be performed in order to attempt to prevent movement, and to consider the position of patients, the CT image and the LA size. P1917 Coagulation dysfunction can be improved by statin in atrial fibrillation regardless of cholesterol level H.W. Park, N.S. Yoon, K.H. Kim, Y.J. Hong, J.H. Kim, Y.K. Ahn, M.H. Jeong, J.G. Cho, J.C. Park, J.C. Kang. Chonnam National University Hospital, Cardiovascular Medicine, Gwangju, Korea, Republic of Background: Circulating lipids appear to have prothrombotic and endotheliumaltering properties. Atrial fibrillation is associated with thromboembolism, endothelial dysfunction and abnormalities in coagulation system. However, it is not certain whether statin may reverse prothombotic condition in atrial fibrillation. Methods: Consecutive 306 atrial fibrillation patients were enrolled. Patients of group I had dyslipidemia and received statin for more than 6 months (n=122, 59±11 years) and group II had not dyslipidemia and did not receive statin (n=184, 56±17 years). Markers for endothelial function (von-Willebrand factor, vWF; factor 8 related antigen and ristocetin cofactor), inflammation [WBCs, ESR, quantitative and high sensitivity C-reactive protein] and coagulation system (fibrinogen, fibrinogen degradation product, fibrin d-dimer) and platelet activity (p-selectin) were measured. Results: There were no significant differences in levels of markers for endothelial dysfunction or inflammation between 2 groups. Total and LDL-cholesterol levels were significantly higher in group I than in group II (185±44 mg/dL vs 169±35 mg/dL, p=0.001; 124±45mg/dL vs 102±29mg/dL, p=0.001). Even though fibrinogen level was not different between 2 groups (group I; 303±88 mg/dL, group II; 287±84 mg/dL, p=0.107), fibrinogen degradation product level was significantly lower in group I (1.1±1.7 ug/mL vs 2.2±4.6 ug/mL, p=0.024). D-dimer level also was significantly lower in group I than group II (0.19±0.19 mg/L vs 0.27±0.29 mg/L, p= 0.013). Conclusion: Statin showed beneficial effect on coagulation system in patients with atrial fibrillation regardless of their cholesterol level and statin may reduce thromboembolism in patients with atrial fibrillation P1918 Pulmonary veins remodeling and transcatheter ablation of atrial fibrillation V. Scarabeo, G. De Simone, F. De Conti, P. Turrini, R. Verlato, N. Lafisca, A. Zampiero, P. Piovesana. Camposampiero Hospital, Cardiology, Camposampiero (Pd), Italy Introduction: Radiofrequency circumferential isolation of the pulmonary veins is a recently introduced ablation technique for the treatment of atrial fibrillation. This study evaluated pulmonary veins remodeling at long term follow-up after transcatheter ablation of atrial fibrillation. Methods: 81 patients undergoing pulmonary veins isolation procedure were included. All patients underwent transoesophageal echocardiogram before and three months after the procedure. Anatomical and functional study of the pulmonary veins was assessed. In case of abnormal pulmonary veins flow detection the exam was repeated at 12 months follow-up. Results: In 80 patients (98,7% of cases) visualization of veno-atrial junction was successfully done. Before ablation mean diameter of the left superior pulmonary vein resulted 1,19±0,64cm; left inferior pulmonary vein was 1,07±0,57cm; right superior pulmonary vein 1,28±0,69cm and right inferior pulmonary vein 0,69±0,52cm. During follow-up there was a significant size reduction only of the left inferior pulmonary vein (p=0,02), corresponding to a 10% lumen reduction, defined as a mild stenosis. Venous flow analysis revealed increased flow velocity in 20 patients (≥100cm/s); in 4 patients flow velocity resulted >150 cm/s. Increased flow velocity involved the left superior pulmonary vein and the right superior pulmonary vein in the same number of patients (12 patients, 14,8%). 10 patients Atrial fibrillation 291 (12,3%) had two vessels with increased flow velocity, 5 patients (6,1%) had one vessel and 3 patients (3,7%) three vessels. One patient presented a 62,5% lumen reduction compared to baseline value, resulting in a moderate stenosis, not requiring interventional treatment. All patients were asymptomatic, and didn’t develop pulmonary hypertension after procedure. Conclusions: Study of pulmonary veins remodeling after ablation procedure showed a significant lumen reduction (narrowing by 10%) only in the left inferior pulmonary vein and a flow velocity increase of one or more vessels, but not requiring treatment. P1919 Have the same significance prior or acute atrial fibrillation in octogenarian patients with acute myocardial infarction? J. Galcera Tomas1 , A. Melgarejo-Moreno2 , A. Padilla-Serrano3 , N. Alonso-Fernandez2 , J.H. De Egea-Garcia 3 , D. Martinez-Bano3 , A. Ortin-Freire3 , R. Jimenez-Sanchez3 , G. Escudero2 , P. Rodriguez-Garcia3 . 1 2 Murcia, Spain; Hospital Universitario Santa Maria del Rosell, Cartagena, Spain; 3Hospital Universitario Virgen de la Arrixaca, Murcia, Spain Purpose: To study peculiarities and prognostic significance of atrial fibrillation (AF) depending of being previous (PAF) or presumed new appearance (NAAF) in octogenarian patients (OP) with acute myocardial infraction (MI). Methods: Prospectively in all OP admitted with acute MI from October 1997 to October 2007 to the Coronary Unit of two hospital of Murcia Region of Spain, incidence of AF and its classification as PAF or NAAF was established. Survival was studied by Kaplan-Meier curves and their association with mortality by multivariable analysis. Results: Among 775 OP-patients, 211 had AF: PAF N=77 and NAAF N=134. Patients with PAF were older (84±3 vs82±4, pI (64 vs 38% pII (21 vs 36%, p
Page 1 and 2: Monday, 1 September 2008 Downloaded
Page 3 and 4: CAN WE PREDICT ATRIAL FIBRILLATION?
Page 5 and 6: Thromboembolic risks and therapeuti
Page 7 and 8: Healthy bone marrow for a healthy h
Page 9 and 10: NEW PROGNOSTIC MARKERS IN ACUTE CAR
Page 11 and 12: CI 0.2-1.6, p=0.32) after epinephri
Page 13 and 14: Risk assessment: strengths and weak
Page 15 and 16: Prognosis in heart failure: surveys
Page 17 and 18: Restenosis: is there an alternative
Page 19 and 20: Confonding factors influencing outc
Page 21 and 22: New vessels and changed vessels: an
Page 23 and 24: (n=574) served as the cohort where
Page 25 and 26: Using Cox’s proportional hazards
Page 27 and 28: hibitory response, or in pts with p
Page 29 and 30: Multimodality imaging of coronary h
Page 31 and 32: Conclusions: EVH is a strong indepe
Page 33 and 34: any antiarrhythmic drug (AAD), Grou
Page 35: oxidases decreased O2- by 16±3.1%
Page 39 and 40: manent AF were studied. The number
Page 41 and 42: P1933 Left atrial appendage dominan
Page 43 and 44: hydrolysable, it would dissipate be
Page 45 and 46: P1949 A first-in-human clinical tri
Page 47 and 48: P1957 Electrophysiological effects
Page 49 and 50: for the population of Tayside, Scot
Page 51 and 52: P1973 Effect of ursodeoxycholic aci
Page 53 and 54: =0.31, p=0.0003) and QUICKI (r=0.29
Page 55 and 56: P1989 Hormonal mechanisms of cachex
Page 57 and 58: or more of the following ECG change
Page 59 and 60: P2004 Association between cardiovas
Page 61 and 62: P2012 Correlations between the degr
Page 63 and 64: disease. Familial study was recomen
Page 65 and 66: P2027 MRI for the detection of rest
Page 67 and 68: P2035 Oxidized low density lipoprot
Page 69 and 70: P2042 Persistent under representati
Page 71 and 72: P2049 Addition of B-type natriureti
Page 73 and 74: P2058 Genetic variation in CYP2C19
Page 75 and 76: p=0.003). Minor bleeding was also l
Page 77 and 78: Avidin, a protein found in hen eggs
Page 79 and 80: flow, and
Page 81 and 82: (PCWP) were recorded. In 16 patient
Page 83 and 84: Methods: A prospective, consecutive
Page 85 and 86: over paclitaxel-eluting stent (PES)
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which proved to be safe and effecti
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Comparison of neointimal growth amo
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patients between October 2006 and J
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P2139 Inverse relation of baseline
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tive. We sought to determine the ef
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P2155 A very high prevalence of low
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P2163 The influence of estradiol on
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2nd year of follow-up, respectively
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P2179 Symptoms of atrial fibrillati
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P2187 The relationships of ambulato
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tension (WCHT) to vascular damage i
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in the postero- and midseptal regio
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elevation myocardial infarction (AM
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assigned to receive either unselect
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was injected. Left ventricular func
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of MACE in patients with LGE and de
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P2243 Blood oxygenation level-depen
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P2250 Prognostic value of revascula
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needed to achieve 90% of age-predic
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presence/absence of VIVC assessed u
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2341 Telemonitoring in an elderly,
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Heart failure with preserved systol
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the most dilated, LA mostly influen
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Conclusion: In patients with stable
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2388 Magnitude of glycaemia variati
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patients with RV > 30 ml this corre
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BIOMARKERS: NEW KIDS ON THE BLOCK 2
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the importance of calling the emerg
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Sudden death, devices and public aw
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Bone marrow progenitors: filling th
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2566 Esophageal capsule endoscopy i
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(7.0%) patients receiving aliskiren
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P2600 Final aggregation response is
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Results: Female patients (27.7%) we
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with atrial fibrillation (AF) under
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e feasible and safe. This approach
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coagulant therapy (P=0.038; OR=2.42
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ison between responders and nonresp
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Table 1. Systolic, diastolic and dy
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Syncope and cardiac pacing: miscell
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their downstream effector, myosin h
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Understanding determinants of hemod
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the abundance of profibrotic CCN2 p
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parison with IL-8 as well as the ex
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and EF (-0.5%) which significantly
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of effects on systemic BP and cardi
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Conclusion: Compared to previously
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P2723 Differential virus-associated
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Methods: During 2007, 10 patients (
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cardiomyocyte apoptosis was highest
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higher for NT-proBNP (area under th
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or higher) in 85 patients (4.2%). M
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teria as a final Thrombolysis In My
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cantly correlated to in-hospital de
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nosis in patients with myocardial i
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lesion classification, stent type u
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Prognosis in ST-elevation myocardia
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P2802 In-hospital and long-term mor
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P2810 Long-term clinical results fo
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Percutaneous coronary intervention;
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vessels (DES 16.7%, BMS 6.7%, p=0.0
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patients receiving a DES and the ra
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Results: The two groups had similar
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among their non-DM counterparts (HR
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tigated the long-term consequences
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culogenesis. Reduction of VPC and E
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y echo-tracking technique calibrate
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P2885 Statins are effective in redu
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Conclusions: The patient-centred he
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P2900 Should left ventricular hyper
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P2908 Telmisartan up-regulates the
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important sex-based differences in
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Hypertension: regional and ethnic p
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whether the selective mineralocorti
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THE ENDOTHELIUM: AT THE HEART OF VA
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P2951 Reproducibility of endothelia
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P2959 Brachial flow-mediated dilati
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P2966 Detection of late enhancement
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tissue as an enhanced area. On the
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dial dysfunction is critical for th
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for testing the load dependence. Th
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diastolic velocity (-12.3±4.9 vs -
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Monday, 1 September 2008 - European Heart Journal

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