Monday, 1 September 2008 - European Heart Journal

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$Heart failure with preserved ejection fraction - European Heart Journal$

274 New vessels and changed vessels: angiogenesis and vascular remodelling Notch ligand Delta-like (Dll) 4 regulates arterial differentiation in embryonic development, but the key ligand in mature CA remains elusive. Here we identify the Notch ligand Dll1 as an essential regulator of postnatal coronary arteriogenesis, which is protective after myocardial infarction. Methods and Results: To characterize expression and role of Dll1 in adult hearts we analyzed heterozygous Dll1-lacZ/+ reporter mice, in which one allele of Dll1 has been replaced by lacZ. X-gal staining revealed selective Dll1 expression in the endocardium and in endothelium of coronary arteries (CA), but not in veins or capillaries. Interestingly, hearts from Dll1 heterozygous mice were smaller (heart weight (g)/femur length (cm), wt: 0.13±0.02 vs. het: 0.09±0.02, n=10, p20 um) but an increased number of small arterioles
New vessels and changed vessels: angiogenesis and vascular remodelling / Syncope: still a lot to learn 275 due to prevention of platelet aggregation. In contrast, complete loss of platelets appears to be detrimental, suggesting a supportive role for platelet recruitment in the arteriogenic process. These findings establish the platelet as a major player in arteriogenesis. 1820 A critical role of platelet function in arteriogenesis M.L. Von Bruehl1 , J. Pagel2 , W. Schaper3 , E. Deindl2 ,S.Massberg1 . 1Deutsches Herzzentrum, Experimental Cardiology, Muenchen, Germany; 2Walter-Brendel-Center for Exp. Medicine, Ludwig- Maximilians-University, Muenchen, Germany; 3Max-Planck-Insitute, Bad Nauheim, Germany Background: The compensatory growth of blood vessels after major arterial occlusions (arteriogenesis) describes the remodelling of pre-existing arterioarteriolar anastomoses to large functional arteries. The growth is triggered by fluid shear stress initiating endothelial activation and modulating processes, which control attraction of circulating cells. Although recruitment of monocytes and Tcells has been identified during arteriogenesis, the exact cellular mechanisms underlying the arteriogenic process are still ill defined. Platelets play a pivotal role not only in hemostasis but also in acute and chronic inflammatory processes of the vascular wall; however, their contribution to arteriogenesis remains unclear. Methods: To examine the arteriogenic role of the platelets, male or female GPIIb (αIIb integrin)-deficient mice (n=7) underwent right femoral artery ligation to induce arteriogenesis. The left femoral artery was sham operated. WT littermates served as controls. In separate experiments, thrombocytopenia (
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Page 3 and 4: CAN WE PREDICT ATRIAL FIBRILLATION?
Page 5 and 6: Thromboembolic risks and therapeuti
Page 7 and 8: Healthy bone marrow for a healthy h
Page 9 and 10: NEW PROGNOSTIC MARKERS IN ACUTE CAR
Page 11 and 12: CI 0.2-1.6, p=0.32) after epinephri
Page 13 and 14: Risk assessment: strengths and weak
Page 15 and 16: Prognosis in heart failure: surveys
Page 17 and 18: Restenosis: is there an alternative
Page 19: Confonding factors influencing outc
Page 23 and 24: (n=574) served as the cohort where
Page 25 and 26: Using Cox’s proportional hazards
Page 27 and 28: hibitory response, or in pts with p
Page 29 and 30: Multimodality imaging of coronary h
Page 31 and 32: Conclusions: EVH is a strong indepe
Page 33 and 34: any antiarrhythmic drug (AAD), Grou
Page 35 and 36: oxidases decreased O2- by 16±3.1%
Page 37 and 38: Fig. 1. Five types of merge errors.
Page 39 and 40: manent AF were studied. The number
Page 41 and 42: P1933 Left atrial appendage dominan
Page 43 and 44: hydrolysable, it would dissipate be
Page 45 and 46: P1949 A first-in-human clinical tri
Page 47 and 48: P1957 Electrophysiological effects
Page 49 and 50: for the population of Tayside, Scot
Page 51 and 52: P1973 Effect of ursodeoxycholic aci
Page 53 and 54: =0.31, p=0.0003) and QUICKI (r=0.29
Page 55 and 56: P1989 Hormonal mechanisms of cachex
Page 57 and 58: or more of the following ECG change
Page 59 and 60: P2004 Association between cardiovas
Page 61 and 62: P2012 Correlations between the degr
Page 63 and 64: disease. Familial study was recomen
Page 65 and 66: P2027 MRI for the detection of rest
Page 67 and 68: P2035 Oxidized low density lipoprot
Page 69 and 70: P2042 Persistent under representati
Page 71 and 72:
P2049 Addition of B-type natriureti
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P2058 Genetic variation in CYP2C19
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p=0.003). Minor bleeding was also l
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Avidin, a protein found in hen eggs
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flow, and
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(PCWP) were recorded. In 16 patient
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Methods: A prospective, consecutive
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over paclitaxel-eluting stent (PES)
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which proved to be safe and effecti
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Comparison of neointimal growth amo
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patients between October 2006 and J
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P2139 Inverse relation of baseline
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tive. We sought to determine the ef
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P2155 A very high prevalence of low
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P2163 The influence of estradiol on
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2nd year of follow-up, respectively
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P2179 Symptoms of atrial fibrillati
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P2187 The relationships of ambulato
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tension (WCHT) to vascular damage i
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in the postero- and midseptal regio
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elevation myocardial infarction (AM
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assigned to receive either unselect
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was injected. Left ventricular func
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of MACE in patients with LGE and de
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P2243 Blood oxygenation level-depen
Page 121 and 122:
P2250 Prognostic value of revascula
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needed to achieve 90% of age-predic
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presence/absence of VIVC assessed u
Page 127 and 128:
2341 Telemonitoring in an elderly,
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Heart failure with preserved systol
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the most dilated, LA mostly influen
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Conclusion: In patients with stable
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2388 Magnitude of glycaemia variati
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patients with RV > 30 ml this corre
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BIOMARKERS: NEW KIDS ON THE BLOCK 2
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the importance of calling the emerg
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Sudden death, devices and public aw
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Bone marrow progenitors: filling th
Page 147 and 148:
2566 Esophageal capsule endoscopy i
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(7.0%) patients receiving aliskiren
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P2600 Final aggregation response is
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Results: Female patients (27.7%) we
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with atrial fibrillation (AF) under
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e feasible and safe. This approach
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coagulant therapy (P=0.038; OR=2.42
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ison between responders and nonresp
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Table 1. Systolic, diastolic and dy
Page 165 and 166:
Syncope and cardiac pacing: miscell
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their downstream effector, myosin h
Page 169 and 170:
Understanding determinants of hemod
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the abundance of profibrotic CCN2 p
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parison with IL-8 as well as the ex
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and EF (-0.5%) which significantly
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of effects on systemic BP and cardi
Page 179 and 180:
Conclusion: Compared to previously
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P2723 Differential virus-associated
Page 183 and 184:
Methods: During 2007, 10 patients (
Page 185 and 186:
cardiomyocyte apoptosis was highest
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higher for NT-proBNP (area under th
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or higher) in 85 patients (4.2%). M
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teria as a final Thrombolysis In My
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cantly correlated to in-hospital de
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nosis in patients with myocardial i
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lesion classification, stent type u
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Prognosis in ST-elevation myocardia
Page 201 and 202:
P2802 In-hospital and long-term mor
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P2810 Long-term clinical results fo
Page 205 and 206:
Percutaneous coronary intervention;
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vessels (DES 16.7%, BMS 6.7%, p=0.0
Page 209 and 210:
patients receiving a DES and the ra
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Results: The two groups had similar
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among their non-DM counterparts (HR
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tigated the long-term consequences
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culogenesis. Reduction of VPC and E
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y echo-tracking technique calibrate
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P2885 Statins are effective in redu
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Conclusions: The patient-centred he
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P2900 Should left ventricular hyper
Page 227 and 228:
P2908 Telmisartan up-regulates the
Page 229 and 230:
important sex-based differences in
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Hypertension: regional and ethnic p
Page 233 and 234:
whether the selective mineralocorti
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THE ENDOTHELIUM: AT THE HEART OF VA
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P2951 Reproducibility of endothelia
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P2959 Brachial flow-mediated dilati
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P2966 Detection of late enhancement
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tissue as an enhanced area. On the
Page 245 and 246:
dial dysfunction is critical for th
Page 247 and 248:
for testing the load dependence. Th
Page 249:
diastolic velocity (-12.3±4.9 vs -
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Monday, 1 September 2008 - European Heart Journal

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