Monday, 1 September 2008 - European Heart Journal

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$Heart failure with preserved ejection fraction - European Heart Journal$

282 Multimodality imaging of coronary heart disease Table 1. Main long-term mortality predictors Without previous infarction With previous infarction HR (95% CI) P HR (95% CI) P Age 1.07 (1.04-1.09)
Multimodality imaging of coronary heart disease / Optimisation of techniques and adjunct therapy in cardiac surgery 283 sitivity, specifity, negative predictive and positive predictive value, and accuracy for GRE-MRI analysis of myocardial perfusion in the detection of flow-limiting epicardial coronary artery lesions, as defined as diameter stenosis >50%, were 72%,100%, 54%, 100% and 73%, respectively. Conclusions: These preliminary results indicate a moderate diagnostic accuracy of cardiac GRE-MRI perfusion imaging at least during dipyridamole-induced coronary flow increases in the detection of flow-limiting epicardial artery lesions. The concordance between 201TI-SPECT and cardiac GRE-MRI imaging in the detection of stress-induced perfusion defects was relatively low, and 39% of 201TI- SPECT-determined perfusion defects were not identified by cardiac GRE-MRI, that deserves further investigations. P1880 Myocardial T2* estimation techniques in iron overload disease: relationship with left ventricular function M. Leung, G. Brown, A. Carbone, S. Worthley. Royal Adelaide Hospital, Adelaide, Australia Objectives: Myocardial T2* relaxometry has been proposed as a measure of myocardial iron accumulation and is associated with fatal heart failure. Its estimation can be observer dependent, limiting its clinical utility. We developed explicit rules for data acquisition and analysis and assessed their impact on myocardial T2* estimate (myoT2*), its reproducibility and relationship with left ventricular function. Methods: Mid-septum short-axis segmented FLASH images with 11 TE values (3.6-18ms) were acquired on 30 patients with congenital haemoglobinopathy. Mean pixel values at the inter-ventricular septum were graphed against TE. myoT2* was derived from exponential regression analysis. Comparison between 11 and standard 9 TE values (5.6-18ms), and the inclusion/exclusion of myocardial signal indistinguishable (signal-1SD < noise+1SD) from background noise (noise test) was performed by Bland-Altman analysis. Intra-, inter-observer and inter-study variability were assessed by % coefficient of variation (%CV) and Bland-Altman analysis. Results: Observed myoT2* was 16.4±12.2ms (mean±SD). 11 versus 9 TE demonstrated a myoT2* mean difference (95% limits of agreement) of -0.4ms (-6.2, 5.4ms), and with/without noise test of 0.3ms (-2.6, 3.2ms). With 11 TE and noise test, intra-, inter-observer and inter-study %CV were 6.4%, 8.1% and 5% respectively. Mean difference between observations (95% limits of agreement) for all myoT2*, myoT2*>20ms (normal) and ≤20ms (abnormal) are shown in Table 1. Logn myoT2* correlated with LVEF (P=0.021, R=0.433). Table 1. Reproducibility of myoT2* Reproducibility myoT2* range Mean Difference 95% Limits of Agreement Intra-observer all myoT2* 0.3ms -5.0 to 5.7ms myoT2*≤ 20 ms -0.08ms -3.5 to 3.3ms myoT2*> 20 ms 0.8ms -6.5 to 8.2ms Inter-observer all myoT2* 0.5ms -3.6 to 4.7ms myoT2*≤ 20 ms 0.6ms -1.7 to 2.9ms myoT2*> 20 ms 0.5ms -6.0 to 7.0ms Inter-study all myoT2* 0.1ms -4.0 to 4.3ms myoT2*≤ 20 ms 0.1ms -2.2 to 2.5ms myoT2*> 20 ms 0.08ms -6.9 to 7.1ms Conclusions: This myoT2* methodology demonstrated high reproducibility and correlated with left ventricular function. P1881 Variables associated with contrast enhanced cardiovascular magnetic resonance in hypertrophic cardiomyopathy: importance of quantification and pattern of enhancement F. Marin Ortuno1 , J. Gonzalez1 , A. Garcia Honrubia2 , A. Romero1 , V. Climent2 , F. Ruiz Espejo1 , V. Roldan3 ,J.R.Gimeno1 , G. De La Morena1 , M. Valdes1 . 1Hospital Virgen de la Arrixaca, Murcia, Murcia, Spain; 2Hospital General Universitario, Cardiology, Alicante, Spain; 3Universidad de Murcia, Centro Regional de Hemodonacion, Murcia, Spain Hypertrophic cardiomyopathy (HCM) shows increased myocardial collagen and disarray. Late gadolinium-enhancement (LGE) in cardiovascular magnetic resonance (CMR) is observed in regions of increased myocardial collagen. The extent of LGE has been associated with higher prevalence of risk factors of sudden death. The aim of the present study was to describe the clinical characteristics and the presence of risk factors for sudden death in a series of patients from two referral centres for HCM in relation to LGE in CMR. Methods: 120 patients (47±16 years) were included. All patients fulfilled conventional criteria for HCM. Risk factors for sudden death were evaluated. A blinded CMR was performed with LGE in the left ventricular short-axis orientation. Quantification of LGE was performed by Mass Suite software. A qualitative analysis of the presence of LGE was also done. NT-proBNP and C-reactive protein were determined in serum samples. Results: 83 patients (69%) showed LGE. These patients had higher maximal left ventricular wall thickness (22±5vs.17±3 mm,p
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Page 3 and 4: CAN WE PREDICT ATRIAL FIBRILLATION?
Page 5 and 6: Thromboembolic risks and therapeuti
Page 7 and 8: Healthy bone marrow for a healthy h
Page 9 and 10: NEW PROGNOSTIC MARKERS IN ACUTE CAR
Page 11 and 12: CI 0.2-1.6, p=0.32) after epinephri
Page 13 and 14: Risk assessment: strengths and weak
Page 15 and 16: Prognosis in heart failure: surveys
Page 17 and 18: Restenosis: is there an alternative
Page 19 and 20: Confonding factors influencing outc
Page 21 and 22: New vessels and changed vessels: an
Page 23 and 24: (n=574) served as the cohort where
Page 25 and 26: Using Cox’s proportional hazards
Page 27: hibitory response, or in pts with p
Page 31 and 32: Conclusions: EVH is a strong indepe
Page 33 and 34: any antiarrhythmic drug (AAD), Grou
Page 35 and 36: oxidases decreased O2- by 16±3.1%
Page 37 and 38: Fig. 1. Five types of merge errors.
Page 39 and 40: manent AF were studied. The number
Page 41 and 42: P1933 Left atrial appendage dominan
Page 43 and 44: hydrolysable, it would dissipate be
Page 45 and 46: P1949 A first-in-human clinical tri
Page 47 and 48: P1957 Electrophysiological effects
Page 49 and 50: for the population of Tayside, Scot
Page 51 and 52: P1973 Effect of ursodeoxycholic aci
Page 53 and 54: =0.31, p=0.0003) and QUICKI (r=0.29
Page 55 and 56: P1989 Hormonal mechanisms of cachex
Page 57 and 58: or more of the following ECG change
Page 59 and 60: P2004 Association between cardiovas
Page 61 and 62: P2012 Correlations between the degr
Page 63 and 64: disease. Familial study was recomen
Page 65 and 66: P2027 MRI for the detection of rest
Page 67 and 68: P2035 Oxidized low density lipoprot
Page 69 and 70: P2042 Persistent under representati
Page 71 and 72: P2049 Addition of B-type natriureti
Page 73 and 74: P2058 Genetic variation in CYP2C19
Page 75 and 76: p=0.003). Minor bleeding was also l
Page 77 and 78: Avidin, a protein found in hen eggs
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flow, and
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(PCWP) were recorded. In 16 patient
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Methods: A prospective, consecutive
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over paclitaxel-eluting stent (PES)
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which proved to be safe and effecti
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Comparison of neointimal growth amo
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patients between October 2006 and J
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P2139 Inverse relation of baseline
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tive. We sought to determine the ef
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P2155 A very high prevalence of low
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P2163 The influence of estradiol on
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2nd year of follow-up, respectively
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P2179 Symptoms of atrial fibrillati
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P2187 The relationships of ambulato
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tension (WCHT) to vascular damage i
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in the postero- and midseptal regio
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elevation myocardial infarction (AM
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assigned to receive either unselect
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was injected. Left ventricular func
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of MACE in patients with LGE and de
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P2243 Blood oxygenation level-depen
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P2250 Prognostic value of revascula
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needed to achieve 90% of age-predic
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presence/absence of VIVC assessed u
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2341 Telemonitoring in an elderly,
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Heart failure with preserved systol
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the most dilated, LA mostly influen
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Conclusion: In patients with stable
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2388 Magnitude of glycaemia variati
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patients with RV > 30 ml this corre
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BIOMARKERS: NEW KIDS ON THE BLOCK 2
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the importance of calling the emerg
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Sudden death, devices and public aw
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Bone marrow progenitors: filling th
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2566 Esophageal capsule endoscopy i
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(7.0%) patients receiving aliskiren
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P2600 Final aggregation response is
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Results: Female patients (27.7%) we
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with atrial fibrillation (AF) under
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e feasible and safe. This approach
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coagulant therapy (P=0.038; OR=2.42
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ison between responders and nonresp
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Table 1. Systolic, diastolic and dy
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Syncope and cardiac pacing: miscell
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their downstream effector, myosin h
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Understanding determinants of hemod
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the abundance of profibrotic CCN2 p
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parison with IL-8 as well as the ex
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and EF (-0.5%) which significantly
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of effects on systemic BP and cardi
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Conclusion: Compared to previously
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P2723 Differential virus-associated
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Methods: During 2007, 10 patients (
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cardiomyocyte apoptosis was highest
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higher for NT-proBNP (area under th
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or higher) in 85 patients (4.2%). M
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teria as a final Thrombolysis In My
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cantly correlated to in-hospital de
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nosis in patients with myocardial i
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lesion classification, stent type u
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Prognosis in ST-elevation myocardia
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P2802 In-hospital and long-term mor
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P2810 Long-term clinical results fo
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Percutaneous coronary intervention;
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vessels (DES 16.7%, BMS 6.7%, p=0.0
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patients receiving a DES and the ra
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Results: The two groups had similar
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among their non-DM counterparts (HR
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tigated the long-term consequences
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culogenesis. Reduction of VPC and E
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y echo-tracking technique calibrate
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P2885 Statins are effective in redu
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Conclusions: The patient-centred he
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P2900 Should left ventricular hyper
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P2908 Telmisartan up-regulates the
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important sex-based differences in
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Hypertension: regional and ethnic p
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whether the selective mineralocorti
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THE ENDOTHELIUM: AT THE HEART OF VA
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P2951 Reproducibility of endothelia
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P2959 Brachial flow-mediated dilati
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P2966 Detection of late enhancement
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tissue as an enhanced area. On the
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dial dysfunction is critical for th
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for testing the load dependence. Th
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diastolic velocity (-12.3±4.9 vs -
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Monday, 1 September 2008 - European Heart Journal

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