MEDICINSKI GLASNIK - Aktuelno Ljekarska komora ZE - DO kantona

22
Medicinski Glasnik, Volumen 8, Number 1, February 2011
Figure 2. Distribution of the nuchal translucency values (NT) in
relation to the crown-rump length (CRL) in the total sample.
Distribution of NT values in relation to the median
in the control group (1.90 mm) was 135:301,
or 55.15% above the median, or 44.85% below
the median (Figure 2,3).
The distribution of NT thickness values measured
in relation to the median (2.55 mm) NT with
pathological karyotype after invasive diagnostic
was 11:5 or 68.75% above the median, or 31.25%
below the median (Figures 4,5).
The analysis of the total sample found 26 pregnant
women with NT above the median of 2.55
mm for the given CRL and 61.54% of fetal chromosomal
aberrations were confirmed by invasive
diagnostic methods (Figures 4, 5).
DISCUSSION
Fetal chromosomal aberrations were found in 16
pregnant women, which could be explained by
sample preselection (all pregnant women suspected
of fetal annormalities). Fetal nuchal translucence
(NT) increases with a rise in CRL, therefore
it is very important to obtain correct CRL measurements
(12). The analysis of the NT values distribution
has shown that the values were distributed
Figure 3. Distribution of the nuchal translucency values (NT)
in relation to the gestational age (NG) in the total sample
Figure 4. Distribution of nuchal translucency values with
pathological karyotype (NT pat) as compared to the crownrump
length (CRL pat)
around the median (2.55 mm) with 44% NT values
below and 56% above the median value, which
is in agreement with quality control criteria established
by the Fetal Medicine Foundation (FMF)
(13). According to FMF criteria the gestational age
should be between 11 and 13+6 weeks, and the
CRL between 45 and 84 mm (14, 15). The distribution
of fetal NT values for the given CRL in our
study did not differ from the standard distribution
described by the FMF. Therefore, our NT measurements
were properly performed. Bаrclay measured
NT in the sample of 11,281 pregnant women
and found 118 inborn fetal anomalies with
52 trisomy, 21, 71.2% of which had NT above
the 95th percentile (3 mm) in the period between
11 and 14 weeks gestation. In the same study, this
number falls down to 56 % in the period between
15 and 16 weeks gestation (16). Measuring NT in
32,000 fetuses of gestational age between 11 and
14 weeks Mаnni has found average age of the pregnant
women was 32 years, in 5.1% fetuses NT
was above the 95th percentile (3 mm) and 87.1% of
which had a normal karyotype; out of 110 diagno-
Figure 5. Distribution of nuchal translucency values with
pathologic karyotype (NT pat) in relation to gestational age of
the pregnancy (NG pat)