JOURACA_SP_2017

Creation of Imidazo[1,5-a]
pyridine Ligands
Kaitlyn Roberts
In palladium-catalyzed cross-coupling reactions
a carbon-carbon bond is created by the
addition of two carbon fragments with a
transition metal. The "ligand" plays an important
role in the palladium-catalyzed cross
-coupling reactions. Imidazo[1,5-a]
pyridines and imidazo[1,2-a]pyridines are
"privileged structures" in medicinal chemistry.
We propose that these "privileged
structures" will be useful as "ligands" in
palladium-catalyzed cross-coupling reactions.
Efforts have been directed toward the
syntheses of the Imidazo[1,5-a]pyridine and
imidazo[1,2-a]pyridine phosphorus
"ligands" by various synthetic methods. In
the future, we will employ the application of
these ligands towards Suzuki-Miyaura cross
-coupling reactions.
Department of Chemistry
Chemistry
Mentor: Dr. Larry Yet
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