JOURACA_SP_2017
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3D Model for cAMP Intracellular<br />
Signaling<br />
Steven Shettlesworth<br />
Second messengers, such as cyclic adenosine<br />
monophosphate (cAMP), are responsible<br />
for a plethora of cellular functions. The<br />
essential role cAMP signaling plays in living<br />
organisms is well understood, yet there<br />
is still much debate on the information<br />
stored within these signals. In the last decade,<br />
mathematical models have been developed<br />
for explaining concentration of cAMP<br />
gradients. In this report, we will work to<br />
expand a previously constructed 2D finite<br />
element analysis model into three spatial<br />
dimensions. The model is based upon a linearized<br />
partial differential equation developed<br />
around describing the synthesis, degradation,<br />
and spatial diffusion of cAMP. Initially,<br />
a simplified spherical geometry is<br />
used for testing the simulation. The validation<br />
of the results of this analysis will aid in<br />
the model's eventual adaptation into more<br />
realistic complex cellular geometries.<br />
Department of Mechanical Engineering<br />
Mechanical Engineering<br />
Mentor: Dr. Anh-Vu Pahn<br />
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