2017 Cardiovascular Research Day Abstract Book

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103 Alternating heights of the R wave in ECG: possible link with depolarization alternans Sahar Varnoosfaderani 1 , David Wasemiller 1 , Siqi Wang 1 , Paul Anaya 2 , and Abhijit Patwardhan 1 . 1 Department of Biomedical Engineering and 2 Division of <strong>Cardiovascular</strong> Medicine. University of Kentucky. Alternans of the T wave in the ECG (TWA) is widely investigated as a potential predictor of ventricular arrhythmia, however, clinical trials show that TWA has high negative predictive value but poor positive predictive value. A possible reason that TWA has a large number of false positives is that a pattern of alternans, concordant alternans, may not be as arrhythmogenic as discordant alternans. Currently, it is not possible to discern the pattern of alternans using clinical ECGs. However, our research using tissue and cellular level electrophysiological measurements suggest that depolarization alternans which affects the pattern of alternans may manifest itself in the amplitude of the R wave of the ECGs. In order to investigate the link between depolarization alternans and changes in ECGs, we used a mathematical model which simulated ECGs from the cellular level changes observed in our experimental studies. These results suggest that the changes in ECGs should appear as alternating pattern of the heights of the R wave. However, there are a variety of factors which may also cause the R wave heights to change. We use signal analysis and statistical modeling to determine the link between the observed changes in R wave heights and depolarization alternans. Results from ECGs recorded from patients show that heights of the R wave can change as predicted by our experimental results and mathematical models. These results support further exploration of the link between depolarization and repolarization alternans as it has the potential to improve the positive predictive value of TWA. Supported by grants from the Kentucky Science and Engineering Foundation (KSEF RDE18) and NSF EPSCoR RII Track-2. 119
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Cardiovascular Research Day ABSTRAC
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SCHEDULE FOR THE DAY Friday, Novemb
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SCHEDULE FOR THE DAY continued Frid
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2017 GILL HEART INSTITUTE YOUNG INV
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FEATURED SPEAKER Calum MacRae, M.D.
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SPECIAL PRESENTATION Mark Stoops He
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NOTES 12
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2017 POSTER PARTICIPANTS 40 Mohamed
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2017 ABSTRACTS 16
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2 Inhibition of Megalin Reduces Ath
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4 Identification of a Lipid Signatu
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24 Vascular Inflammatory Regulation
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40 The Prognostic Role of Elevated
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48 Ticagrelor Reduces Inflammation
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50 Association between Plasma Chole
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2017 Cardiovascular Research Day Abstract Book

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