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2017 Cardiovascular Research Day Abstract Book

19 Inflammasome

19 Inflammasome Activation Triggers Blood Coagulation through Pyroptosis Congqing Wu, PhD 1 1CVRC, College of Medicine Postdoc Disseminated intravascular coagulation (DIC) is a fatal complication of systemic bacterial infection. Mechanisms for blood coagulation induced by bacterial infection are often attributed to host inflammatory response to bacterial virulence factors, yet the molecular events linking bacteria sensing to initiation of the coagulation cascade remain unclear. Here we identify inflammasome activation as a trigger for coagulation induced by gram-negative bacterial products. Specifically, canonical inflammasome activation elicited by the conserved type III secretion system (T3SS) rod protein EprJ from E. coli induces systemic coagulation through caspase-1 activation, whereas noncanonical inflammasome activation by lipopolysaccharide (LPS), a major outer membrane component of gram-negative bacteria, produces similar effects involving caspase-11. Deficiency of gasdermin D (Gsdmd) or depletion of monocytes and macrophages blocks inflammasome-mediated coagulation. Together, our data unveil inflammasome-dependent pyroptosis leads to blood coagulation. 35

20 Clinical Use of the Amplatzer Septal Occluder in Percutaneous Closure: A Single-Center Experience Seema Rao, MS 1 • Tyler Scaff 1 • John Gurley, MD 2 • Sibu Saha, MD 3 1College of Medicine, University of Kentucky • 2 Cardiology, University of Kentucky • 3 Cardiothoracic Surgery, University of Kentucky Medical Student Device therapy is a viable alternative to open heart surgery in the management of intracardiac defects. The Amplatzer Septal Occluder (ASO) is one such device that has been adapted to close a wide variety of cardiac defects with few complications and a high success rate. This is a retrospective review of all the patients who received the ASO between 2012-2016 at our institution. In total, 169 patients underwent percutaneous closure of a septal defect with Amplatzer during the timeframe studied, and of those, 91% received the device for an atrial septal defect or patent foramen ovale. All Amplatzer devices achieved successful closure without requiring a second procedure. Four patients sustained complications of the procedure, with two experiencing tamponade, one with hematoma, and one with cellulitis. Three fatalities occurred within thirty days and were attributed to comorbidities not related to the device. The ASO has performed very well at our institution and we expect it to serve additional functions as the field of transcatheter cardiology develops. 36

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