2017 Cardiovascular Research Day Abstract Book

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19 Inflammasome Activation Triggers Blood Coagulation through Pyroptosis Congqing Wu, PhD 1 1CVRC, College of Medicine Postdoc Disseminated intravascular coagulation (DIC) is a fatal complication of systemic bacterial infection. Mechanisms for blood coagulation induced by bacterial infection are often attributed to host inflammatory response to bacterial virulence factors, yet the molecular events linking bacteria sensing to initiation of the coagulation cascade remain unclear. Here we identify inflammasome activation as a trigger for coagulation induced by gram-negative bacterial products. Specifically, canonical inflammasome activation elicited by the conserved type III secretion system (T3SS) rod protein EprJ from E. coli induces systemic coagulation through caspase-1 activation, whereas noncanonical inflammasome activation by lipopolysaccharide (LPS), a major outer membrane component of gram-negative bacteria, produces similar effects involving caspase-11. Deficiency of gasdermin D (Gsdmd) or depletion of monocytes and macrophages blocks inflammasome-mediated coagulation. Together, our data unveil inflammasome-dependent pyroptosis leads to blood coagulation. 35
20 Clinical Use of the Amplatzer Septal Occluder in Percutaneous Closure: A Single-Center Experience Seema Rao, MS 1 • Tyler Scaff 1 • John Gurley, MD 2 • Sibu Saha, MD 3 1College of Medicine, University of Kentucky • 2 Cardiology, University of Kentucky • 3 Cardiothoracic Surgery, University of Kentucky Medical Student Device therapy is a viable alternative to open heart surgery in the management of intracardiac defects. The Amplatzer Septal Occluder (ASO) is one such device that has been adapted to close a wide variety of cardiac defects with few complications and a high success rate. This is a retrospective review of all the patients who received the ASO between 2012-2016 at our institution. In total, 169 patients underwent percutaneous closure of a septal defect with Amplatzer during the timeframe studied, and of those, 91% received the device for an atrial septal defect or patent foramen ovale. All Amplatzer devices achieved successful closure without requiring a second procedure. Four patients sustained complications of the procedure, with two experiencing tamponade, one with hematoma, and one with cellulitis. Three fatalities occurred within thirty days and were attributed to comorbidities not related to the device. The ASO has performed very well at our institution and we expect it to serve additional functions as the field of transcatheter cardiology develops. 36
Page 1 and 2: Cardiovascular Research Day ABSTRAC
Page 3 and 4: SCHEDULE FOR THE DAY Friday, Novemb
Page 5 and 6: SCHEDULE FOR THE DAY continued Frid
Page 7 and 8: 2017 GILL HEART INSTITUTE YOUNG INV
Page 9 and 10: FEATURED SPEAKER Calum MacRae, M.D.
Page 11 and 12: SPECIAL PRESENTATION Mark Stoops He
Page 13 and 14: NOTES 12
Page 15 and 16: 2017 POSTER PARTICIPANTS 40 Mohamed
Page 17 and 18: 2017 ABSTRACTS 16
Page 19 and 20: 2 Inhibition of Megalin Reduces Ath
Page 21 and 22: 4 Identification of a Lipid Signatu
Page 23 and 24: 6 Serum Amyloid A Activates the NLR
Page 25 and 26: 8 Azithromycin Therapy Reduces Card
Page 27 and 28: 10 Evidence of Angiotensin II-depen
Page 29 and 30: 12 Auditory Entrainment of Respirat
Page 31 and 32: 14 Cardiac specific Rad knockout In
Page 33 and 34: 16 Hypercholesterolemia Induces Acu
Page 35: 18 A Novel Approach for Modifying I
Page 39 and 40: 22 Regulation of Akt Signaling by N
Page 41 and 42: 24 Vascular Inflammatory Regulation
Page 43 and 44: 26 Vascular inflammation induced ex
Page 45 and 46: 28 Sexual Dimorphism of Angiotensin
Page 47 and 48: 30 Computational modeling of amylin
Page 49 and 50: 32 PCB 126 Exposure Increases Perip
Page 51 and 52: 34 Endothelial Mineralocorticoid Re
Page 53 and 54: 36 Optimization of immunomagnetic s
Page 55 and 56: 38 Gestational Diabetes Provokes Po
Page 57 and 58: 40 The Prognostic Role of Elevated
Page 59 and 60: 42 Lysophosphatidic Acid Receptor 4
Page 61 and 62: 44 Recapitulating In Vivo Fibroblas
Page 63 and 64: 46 Sex-Specific Differences in Card
Page 65 and 66: 48 Ticagrelor Reduces Inflammation
Page 67 and 68: 50 Association between Plasma Chole
Page 69 and 70: 52 Does Light Pollution Affect the
Page 71 and 72: 54 Impact of miR-33 antagonism on m
Page 73 and 74: 56 Isolation and characterization o
Page 75 and 76: 58 The XY sex chromosome complement
Page 77 and 78: 60 CHROME: a Long Non-coding RNA th
Page 79 and 80: 62 Making Good: Secretory Quality C
Page 81 and 82: 64 Thrombospondin 1 (TSP1) Deficien
Page 83 and 84: 66 Serum Amyloid A3 is a High Densi
Page 85 and 86: 68 Adipocyte deficiency of ACE2 inc
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70 Hypercholesterolemia-induced end
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72 Increased Circulating Trimethyla
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74 Circulating Bacterial Small RNA
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76 Pancreatic Beta Cell Export of m
Page 95 and 96:
78 Understanding inhibition of lipo
Page 97 and 98:
80 Insulin signaling regulates apol
Page 99 and 100:
82 Protease-activated Receptor 2 De
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84 Reduced Low-Density Lipoprotein
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86 Pharmacological inhibition of Hu
Page 105 and 106:
88 The Effects of Hypercholesterole
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90 Reduced HDL in mice overexpressi
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92 Human Antigen R (HuR) Regulates
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94 Impact of miR-33 antagonism on c
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96 HB-EGF is a Key Positive Regulat
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98 HDL-miR-223 Communication Pathwa
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100 Short-Term Exercise Training Di
Page 119 and 120:
102 The Ral-Exocyst Pathway Regulat
Page 121 and 122:
NOTES 120
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2017 Cardiovascular Research Day Abstract Book

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