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Akiyama T et al . BMI and age at HCC onset
Table 3 Analysis of factors affecting development of hepatocellular carcinoma at older age (over 80 yr old)
Variables Univariate analysis Multivariate analysis
ment of HCC at an older age (i.e. ≥ 80 years of age) (Table
3). In univariate analysis, the following were significantly
and negatively associated with age at onset of HCC ≥ 80
years: male sex (HR, 0.45; 95% CI, 0.23-0.87; P = 0.017),
diabetes mellitus (HR, 0.23; 95% CI, 0.05-0.96; P = 0.043),
prothrombin activity < 70% (HR, 0.1; 95% CI, 0.01-0.76;
P = 0.025), ALT > 80 IU/L (HR, 0.1; 95% CI, 0.02-0.43;
P = 0.002), and GGT > 50 IU/L (HR, 0.51; 95% CI,
0.26-0.98; P = 0.045). In multivariate analysis, ALT > 80
IU/L was the only independent factor associated with age
at onset of HCC ≥ 80 years (HR, 0.13; 95% CI, 0.03-0.57;
P = 0.007).
Age at onset of HCC stratified by BMI in relation to sex
or alcohol consumption
Differences in age at onset of HCC stratified by BMI
were assessed in relation to sex or alcohol consumption.
In men, age at onset decreased significantly with increasing
BMI (mean age ± SD; underweight, 71.1 ± 7.4 years;
normal weight, 67.0 ± 8.5 years; overweight, 63.6 ± 8.1
years; obese, 57.0 ± 7.0 years) (Figure 3A). Although a
similar trend was noted in women, this was not significant
(underweight, 73.6 ± 7.8 years; normal weight, 70.4
± 7.0 years; overweight, 68.9 ± 6.4 years; obese, 67.0 ± 7.5
years) (Figure 3B).
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HR 95% CI P HR 95% CI P
Sex
Female 1 1
Male 0.45 0.229-0.867 0.017 0.47 0.200-1.119 0.089
BMI