lysosomaux (Schaffner et Schaffnerr, 1987). A l’inverse, l’action des glucocorticoïdes sur les PN induit une inhibition de la réponse oxydative et une diminution de la destruction hyphale (Roilides et al., 1993b). Bien que le rôle majeur des PN ait été établi dans la lutte contre l’API, l’étude de l’inhibition par les glucocorticoïdes de l’activité antifongique des PN n’a pas été plus approfondie à ce jour. H. BIBLIOGRAPHIE Albina, J.E. (1995) - On the expression of nitric oxide in killing of Aspergillus fumigatus conidia by pulmonary alveolar macrophages. Why no NO. J. Leukoc. Biol., 58 : 643-649. Amitami, R., Taylor, G., Elezis, N., Llewellyn-Jones, C., Mitchell, J., Kuez, F., Cole, P.J., Wilson, R. (1995) – Purification and characterization of factors producced by Aspergillus fumigatus wich affect human ciliated respiratory epithelium. Infect. Immun., 63 : 3266-3271. Aufauve-Brown, A., Mellado, E., Gow, N.A.R., Holden, D.W. (1997) – A. fumigatus chsE : A gene related to CHS3 of Saccharomyces cerevisiae and important for hyphal growth and conidiophore development but not pathogenicity. Fungal Genet. Biol., 21 : 141-152. Baldwin, A.S. (1996) – The NF-kB and IkB proteins: new discoveries and insights. Annu. Rev. Immunol., 14 : 649-681. Belvin, M.P., Anderson, K.V. (1996) – A conserved signaling pathway : the Drosophilia toll-dorsal pathway. Ann. Rev. Cell. Dev. Biol., 12 : 393-416. Beutler, B. (1995) - TNF, immunity and inflammatory disease : lessons of the past decade. J. Invest. Med., 43 : 227-235. Boehm, U., Klamp, T., Groot, M., Howard, J.C. (1997) - Cellular response to interferon-g. Annu. Rev. Immunol., 15 : 749-795. Bouchara, J.P., Tronchin, G., Larcher, G., Chabasse, D. (1995) - The search for virulence determinants in Aspergillus fumigatus. Trends Microbiol., 3 : 327-330. Brieland, J.K., Jackson, C., Menzel, F., Loebenberg, D., Cacciapuoti, A., Halpern, J., Hurst, S., Muchamuel, T., Debets, R., Kastelein, R., Churakova, T., Abrams, J., Hare, R., O’Garra, A. (2001) - Cytokine <strong>EPHE</strong> Banque de Monographies SVT 20
networking in lungs of immonucompetent mice in response to inhaled Aspergillus fumigatus. Infect. Immun., 69 : 1554-1560. Brown, J.S., Aufauvre-Brown, A., Brown, J., Jennings, J.M., Arst, H. Jr., Holden, D.W. (2000) - Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity. Mol. Microbiol., 36 : 1371-1380. Calera, J.A., Paris, S., Monod, M., Hamilton, A.J., Debeaupuis, J.P., Diaquin, M., Lopez-Medrano, R., Leal, F., Latgé, J.P. (1997) - Cloning and disruption of the antigenic catalase of A. fumigatus. Infect. Immun., 65 : 4718-4724. Cassatella, M.A., Meda, L., Bonora, S., Ceska, M., Constantin, G. (1993) - IL-10 inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of TNF and IL-1b in mediating the production of IL-8 triggered by LPS. J. Exp. Med., 178 : 2207-2211. Cavaillon, J.M. (éd.)(1996) – Les cytokines. Masson. Paris. Cenci, E., Perito, S., Enssle, K.H., Mosci, P., Latgé, J.P., Romani, L., Bistoni, F. (1997) – Th1 and Th2 cytokines in mice with invasive aspergillosis. Inf. Immun., 65 : 564-570. Cenci, E., Mencacci, A., Fe d’Ostiani, C., Montagnoli, C., Bacci, A., Del Sero, G., Perito, S., Bistoni, F., Romani, L. (1998a) – Cytokine- and T-helper-dependant immunity in murine aspergillosis. Res. Immunol., 149 : 445-454. Cenci, E., Mencacci, A., Fe d'Ostiani, C., Del Sero, G., Mosci, P., Montagnoli, C., Bacci, A., Romani, L. (1998b) - Cytokine- and T helper-dependent lung mucosal immunity in mice with invasive pulmonary aspergillosis. J. Infect. Dis., 178 : 1750-1760. Chmiel, J.F., Konstan, M.W., Knesebeck, J.E., Hilliard, J.B., Bonfield, T.L., Dawson, D.V., Berger, M. (1999) - IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice. Am. J. respir. Crit. Care Med., 160 : 2040-2047. Clemons, K.V., Grunig, G., Sobel, R.A., Mirels, L.F., Rennick, D.M., Stevens, D.A. (2000) – Role of IL-10 in invasive aspergillosis : increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis. Clin. Exp. Immunol., 122 : 186-191. Cox, G. (1996) - IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils. Am. J. Physiol., 271 : 566-571. Cunningham, R., Mahon, B.P. (2001) – The immunological role of respiratory tract epithelium. Mod. Asp. <strong>EPHE</strong> Banque de Monographies SVT 21
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