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Cycle de Krebs.pdf - IBMC

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Régulation du cycle :<br />

‣ Complexe pyruvate déshydrogénase :<br />

• Acétyl-CoA inhibe la transacétylase<br />

• NADH inh. Dihydrolipoyl déshydrogénase<br />

• modification covalente : P <strong>de</strong> Ser<br />

ATP, NADH, Acétyl-CoA<br />

P si<br />

ADP NAD + CoA<br />

• déphosphorylation si pyruvate élevé<br />

élevés<br />

‣ Citrate synthétase :<br />

• inhibée allostériquement par ATP<br />

(ATP baisse l’affinité <strong>de</strong> l’enzyme par l’Acétyl-CoA)

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